Egf MGI Mouse Gene Detail - MGI:95290 - epidermal growth factor

Symbol

Egf
Name

epidermal growth factor

Feature Type

protein coding gene
IDs

MGI:95290
NCBI Gene: 13645
Alliance

gene page
Transcription Start Sites

10 TSS

Sequence Map

Chr3:129471223-129548971 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 58.50 cM
Mapping Data

40 experiments

SNPs within 2kb

2425 from dbSNP Build 142
Strain Annotations

18
RFLP

9

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_95290	protein coding gene	Chr3:129471214-129548971 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0027871	protein coding gene	Chr3:132340864-132423833 (-)
A/J	MGP_AJ_G0027829	protein coding gene	Chr3:127745912-127824237 (-)
AKR/J	MGP_AKRJ_G0027794	protein coding gene	Chr3:131054804-131132943 (-)
BALB/cJ	MGP_BALBcJ_G0027842	protein coding gene	Chr3:127586010-127664029 (-)
C3H/HeJ	MGP_C3HHeJ_G0027571	protein coding gene	Chr3:131447569-131527664 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0028286	protein coding gene	Chr3:137083095-137165997 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025624	protein coding gene	Chr3:123270021-123349436 (-)
CAST/EiJ	MGP_CASTEiJ_G0027028	protein coding gene	Chr3:131124153-131203503 (-)
CBA/J	MGP_CBAJ_G0027547	protein coding gene	Chr3:141697335-141781703 (-)
DBA/2J	MGP_DBA2J_G0027688	protein coding gene	Chr3:126937709-127016389 (-)
FVB/NJ	MGP_FVBNJ_G0027655	protein coding gene	Chr3:124519136-124600301 (-)
LP/J	MGP_LPJ_G0027797	protein coding gene	Chr3:133853600-133935853 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0027686	protein coding gene	Chr3:149646827-149731557 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0028343	protein coding gene	Chr3:130723018-130807838 (-)
PWK/PhJ	MGP_PWKPhJ_G0026752	protein coding gene	Chr3:126668079-126802107 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0026577	protein coding gene	Chr3:128786178-128868863 (-)
WSB/EiJ	MGP_WSBEiJ_G0027107	protein coding gene	Chr3:131435640-131519492 (-)

Human Ortholog

EGF, epidermal growth factor

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

EGF, epidermal growth factor
Synonyms

HOMG4, URG
Links

HGNC:3229

NCBI Gene ID: 1950

neXtProt AC: NX_P01133

UniProt: P01133
Chr Location

4q25; chr4:109912883-110013766 (+) GRCh38

MGI Vertebrate Homology

Egf stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: EGF
Protein SuperFamily

Pro-epidermal_growth_factor
Gene Tree

Egf

Diseases

11 with human EGF associations

				Human Disease	Mouse Models
				endometrial cancer IDs endometrial cancer DOID:1380 DOID:5654 EFO:0004230 ICD10CM:C54.1 KEGG:05213 MESH:D016889 NCI:C27815 NCI:C3012 OMIM:608089 UMLS_CUI:C0007103 UMLS_CUI:C0014170
				gallbladder cancer IDs gallbladder cancer DOID:3121 DOID:8090 DOID:8157 ICD10CM:C23 ICD9CM:156.0 MESH:D005706 NCI:C3048 NCI:C35676 NCI:C7481 UMLS_CUI:C0016978 UMLS_CUI:C0153452 UMLS_CUI:C0278806
				glioblastoma IDs glioblastoma DOID:3068 DOID:3075 DOID:3080 MESH:D005909 NCI:C129295 NCI:C39750 NCI:C9094 UMLS_CUI:C0017636 UMLS_CUI:C0278878 UMLS_CUI:C1514422
				hepatocellular carcinoma IDs hepatocellular carcinoma DOID:684 DOID:5005 EFO:0000182 ICD10CM:C22.0 MESH:D006528 NCI:C3099 OMIM:114550 ORDO:88673 UMLS_CUI:C2239176
				high grade glioma IDs high grade glioma DOID:3070 DOID:2627 KEGG:05214 MESH:D005910 NCI:C3059 NCI:C4822 OMIM:PS137800 ORDO:182067 UMLS_CUI:C0017638 UMLS_CUI:C0555198
				lung adenocarcinoma IDs lung adenocarcinoma DOID:3910 DOID:4826 EFO:0000571 MESH:D000077192 NCI:C27745 NCI:C3512 UMLS_CUI:C0152013 UMLS_CUI:C1335060
				lung non-small cell carcinoma IDs lung non-small cell carcinoma DOID:3908 EFO:0003060 KEGG:05223 MESH:D002289 NCI:C2926 UMLS_CUI:C0007131
				oligodendroglioma IDs oligodendroglioma DOID:3181 DOID:3182 MESH:D009837 NCI:C3288 UMLS_CUI:C0751396
				primary hypomagnesemia IDs primary hypomagnesemia DOID:0060879 ICD10CM:E83.4 OMIM:PS602014 ORDO:34526
				renal hypomagnesemia 4 IDs renal hypomagnesemia 4 DOID:0060882 ICD10CM:E83.4 OMIM:611718 ORDO:34527
				Zollinger-Ellison syndrome IDs Zollinger-Ellison syndrome DOID:0050782 ICD10CM:E16.4 MESH:D015043 NCI:C3453 UMLS_CUI:C0043515

Click on a disease name to see all genes associated with that disease.

References

1 with disease annotations

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
19 phenotypes from multigenic genotypes
19 phenotype references

All Mutations and Alleles

8
Chemically induced (other)

1
Endonuclease-mediated

2
Radiation induced

1
Targeted

4
Genomic Mutations

2 involving Egf
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

56 strains or lines available

Null mutants have normal phenotype. Females triply null, for this locus and the amphiregulin and transforming growth factor alpha genes, are unable to nurse due to impaired mammary gland development and show mild integument and digestive system anomalies.

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All GO Annotations

93
GO References

37

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

905
Tissues

119
cDNA Data

140
Literature Summary

52

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA EGF

Xenbase egf

ZFIN egf

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All Sequences

70
RefSeq

15
UniProt

6
CCDS

CCDS17833.1, CCDS80020.1, CCDS89687.1

Ensembl

ENSMUSG00000028017 (Evidence)
NCBI Gene

13645

			Length	Strain/Species	Flank
genomic	13645	NCBI Gene Model \| MGI Sequence Detail	77749	C57BL/6J	± kb
transcript	NM_010113	RefSeq \| MGI Sequence Detail	4773	ZRU/MplStud
polypeptide	P01132	UniProt \| EBI \| MGI Sequence Detail	1217	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000006928 pre-pro-epidermal growth factor

(term hierarchy)
PDB

1A3P, 1EGF, 1EPG, 1EPH, 1EPI, 1EPJ, 1GK5, 3EGF
InterPro Domains

IPR050778 Cueball/EGF/LRP/Nidogen

IPR018097 EGF-like calcium-binding, conserved site

IPR001881 EGF-like calcium-binding domain

IPR000742 EGF-like domain

IPR000152 EGF-type aspartate/asparagine hydroxylation site

IPR009030 Growth factor receptor cysteine-rich domain superfamily

IPR000033 LDLR class B repeat

IPR049883 NOTCH1 EGF-like calcium-binding domain

IPR016317 Pro-epidermal growth factor

IPR011042 Six-bladed beta-propeller, TolB-like
GlyGen

P01132 5 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)

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All nucleic 162

Genomic 3

cDNA 143

Primer pair 14

Other 2

Microarray probesets 4

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MGD-MRK-9315, MGI:2139798

Summaries

All 267

Developmental Gene Expression 52

Diseases 1

Gene Ontology 37

Phenotypes 19
Earliest

J:70074 Nexo E, et al., Detection of epidermal growth factor-urogastrone and its receptor during fetal mouse development. Proc Natl Acad Sci U S A. 1980 May;77(5):2782-5
Latest

J:353621 Patel VN, et al., Specific 3-O-sulfated heparan sulfate domains regulate salivary gland basement membrane metabolism and epithelial differentiation. Nat Commun. 2024 Aug 31;15(1):7584

TSS for Egf:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr35627	Chr3:129548954-129548975 (-)	6 bp
Tssr35626	Chr3:129548903-129548914 (-)	62 bp
Tssr35625	Chr3:129548661-129548675 (-)	303 bp
Tssr35624	Chr3:129548598-129548604 (-)	370 bp
Tssr35623	Chr3:129548527-129548561 (-)	427 bp
Tssr35622	Chr3:129519938-129519941 (-)	29,031 bp
Tssr35621	Chr3:129518723-129518756 (-)	30,231 bp
Tssr35620	Chr3:129476934-129476973 (-)	72,017 bp
Tssr35619	Chr3:129472084-129472094 (-)	76,882 bp
Tssr35618	Chr3:129471648-129471655 (-)	77,319 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/05/2024 MGI 6.24