Eif4a1 MGI Mouse Gene Detail - MGI:95303 - eukaryotic translation initiation factor 4A1

Symbol

Eif4a1
Name

eukaryotic translation initiation factor 4A1
Synonyms

Eif4, initiation factor eIF-4A long form

Feature Type

protein coding gene
IDs

MGI:95303
NCBI Gene: 13681
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr11:69557762-69563249 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 42.86 cM
Mapping Data

4 experiments

SNPs within 2kb

155 from dbSNP Build 142
Strain Annotations

18
PCR

1
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_95303	protein coding gene	Chr11:69557762-69563249 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0018546	protein coding gene	Chr11:70123842-70131437 (-)
A/J	MGP_AJ_G0018514	protein coding gene	Chr11:67482952-67488455 (-)
AKR/J	MGP_AKRJ_G0018483	protein coding gene	Chr11:69491729-69497216 (-)
BALB/cJ	MGP_BALBcJ_G0018486	protein coding gene	Chr11:67792674-67798162 (-)
C3H/HeJ	MGP_C3HHeJ_G0018299	protein coding gene	Chr11:69512292-69529590 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0018937	protein coding gene	Chr11:72246701-72252283 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016582	protein coding gene	Chr11:64402376-64407965 (-)
CAST/EiJ	MGP_CASTEiJ_G0017854	protein coding gene	Chr11:69763681-69769182 (-)
CBA/J	MGP_CBAJ_G0018272	protein coding gene	Chr11:75480779-75488859 (-)
DBA/2J	MGP_DBA2J_G0018381	protein coding gene	Chr11:67063953-67071360 (-)
FVB/NJ	MGP_FVBNJ_G0018371	protein coding gene	Chr11:66700760-66713791 (-)
LP/J	MGP_LPJ_G0018451	protein coding gene	Chr11:70690907-70697986 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018394	protein coding gene	Chr11:76073893-76079380 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018979	protein coding gene	Chr11:69755273-69760710 (-)
PWK/PhJ	MGP_PWKPhJ_G0017628	protein coding gene	Chr11:67714374-67721496 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0017418	protein coding gene	Chr11:69568980-69580731 (-)
WSB/EiJ	MGP_WSBEiJ_G0017908	protein coding gene	Chr11:69426996-69432605 (-)

Human Ortholog

EIF4A1, eukaryotic translation initiation factor 4A1

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

EIF4A1, eukaryotic translation initiation factor 4A1
Synonyms

DDX2A, EIF-4A, EIF4A, eIF-4A-I, eIF4A-I
Links

HGNC:3282

NCBI Gene ID: 1973

neXtProt AC: NX_P60842

UniProt: P60842
Chr Location

17p13.1; chr17:7572824-7579006 (+) GRCh38

MGI Vertebrate Homology

Eif4a1 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: EIF4A1
Gene Tree

Eif4a1

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Phenotype Summary

6 phenotypes from 1 allele in 2 genetic backgrounds
15 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

15
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

9
Targeted

3
Genomic Mutations

2 involving Eif4a1
Incidental Mutations

APF
Find Mice (IMSR)

17 strains or lines available

Mice with loss of expression in developing B cells display near complete absence of splenic B cells. Loss of expression in mature B cells results in impaired development after activation.

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All GO Annotations

27
GO References

13

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

737
Tissues

27
cDNA Data

41
Literature Summary

7

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase eif4a1

ZFIN eif4a1a, eif4a1b

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All Sequences

134
RefSeq

4
UniProt

13
CCDS

CCDS24904.1

Ensembl

ENSMUSG00000059796 (Evidence)
NCBI Gene

13681

			Length	Strain/Species	Flank
genomic	13681	NCBI Gene Model \| MGI Sequence Detail	5488	C57BL/6J	± kb
transcript	NM_144958	RefSeq \| MGI Sequence Detail	1897	ZRU/MplStud
polypeptide	P60843	UniProt \| EBI \| MGI Sequence Detail	406	Not Applicable

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UniProt

13 Sequences
Protein Ontology

PR:000006986 eukaryotic initiation factor 4A-I

(term hierarchy)
PDB

6XKI, 7DDX
EC

3.6.4.13
InterPro Domains

IPR000629 ATP-dependent RNA helicase DEAD-box, conserved site

IPR044728 ATP-dependent RNA helicase eIF4A, DEAD-box helicase domain

IPR011545 DEAD/DEAH box helicase domain

IPR001650 Helicase, C-terminal domain-like

IPR014001 Helicase superfamily 1/2, ATP-binding domain

IPR027417 P-loop containing nucleoside triphosphate hydrolase

IPR014014 RNA helicase, DEAD-box type, Q motif
GlyGen

P60843 1 site, 1 O-linked glycan (1 site)

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All nucleic 50

Genomic 4

cDNA 42

Primer pair 2

Other 2

Microarray probesets 6

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MGD-MRK-9336, MGD-MRK-9337

Summaries

All 66

Developmental Gene Expression 7

Gene Ontology 13

Phenotypes 15
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:349721 Borisova E, et al., Protein translation rate determines neocortical neuron fate. Nat Commun. 2024 Jun 7;15(1):4879

TSS for Eif4a1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr108772	Chr11:69563233-69563244 (-)	10 bp
Tssr108771	Chr11:69563204-69563224 (-)	35 bp
Tssr108770	Chr11:69563160-69563185 (-)	76 bp
Tssr108769	Chr11:69563133-69563158 (-)	103 bp
Tssr108768	Chr11:69562070-69562110 (-)	1,159 bp
Tssr108767	Chr11:69562040-69562064 (-)	1,197 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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