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Eif5 Gene Detail
Summary
  • Symbol
    Eif5
  • Name
    eukaryotic translation initiation factor 5
  • Synonyms
    2810011H21Rik, D12Ertd549e, MGC:36374, MGC:36509
  • Feature Type
    protein coding gene
  • IDs
    MGI:95309
    NCBI Gene: 217869
  • Alliance
    gene page
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:111504535-111513187 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 61.03 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    230 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95309
 protein coding gene Chr12:111504450-111513187 (+)
129S1/SvImJ MGP_129S1SvImJ_G0020135
 protein coding gene Chr12:113931164-113941849 (+)
A/J MGP_AJ_G0020091
 protein coding gene Chr12:109547911-109556171 (+)
AKR/J MGP_AKRJ_G0020066
 protein coding gene Chr12:112686928-112695687 (+)
BALB/cJ MGP_BALBcJ_G0020076
 protein coding gene Chr12:109968576-109985731 (+)
C3H/HeJ MGP_C3HHeJ_G0019878
 protein coding gene Chr12:113182434-113198821 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020521
 protein coding gene Chr12:117460451-117472919 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018134
 protein coding gene Chr12:105995317-106002049 (+)
CAST/EiJ MGP_CASTEiJ_G0019419
 protein coding gene Chr12:108029487-108040492 (+)
CBA/J MGP_CBAJ_G0019845
 protein coding gene Chr12:121931503-121939760 (+)
DBA/2J MGP_DBA2J_G0019962
 protein coding gene Chr12:109031182-109041540 (+)
FVB/NJ MGP_FVBNJ_G0019947
 protein coding gene Chr12:107828598-107843017 (+)
LP/J MGP_LPJ_G0020037
 protein coding gene Chr12:113738787-113765458 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019985
 protein coding gene Chr12:125061002-125072809 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020550
 protein coding gene Chr12:112198636-112211053 (+)
PWK/PhJ MGP_PWKPhJ_G0019180
 protein coding gene Chr12:103673977-103680463 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018983
 protein coding gene Chr12:106362589-106370261 (+)
WSB/EiJ MGP_WSBEiJ_G0019478
 protein coding gene Chr12:113118448-113124819 (+)



Homology
more
  • Human Ortholog
    EIF5, eukaryotic translation initiation factor 5
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    EIF5, eukaryotic translation initiation factor 5
  • Synonyms
    EIF-5, EIF-5A
  • Links
    NCBI Gene ID: 1983
    neXtProt AC: NX_P55010
    UniProt: P55010

  • Chr Location
    14q32.32; chr14:103333544-103345025 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    23
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    757
  • Tissues
    44
  • cDNA Data
    33
  • Literature Summary
    7
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 217869 NCBI Gene Model | MGI Sequence Detail 8653 C57BL/6J ±  kb
transcript NM_173363 RefSeq | MGI Sequence Detail 3966 ZRU/MplStud  
polypeptide P59325 UniProt | EBI | MGI Sequence Detail 429 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    16 Sequences
  • Protein Ontology
    PR:000007002 eukaryotic translation initiation factor 5
    (term hierarchy)
  • InterPro Domains
    IPR016024 Armadillo-type fold
    IPR045196 Translation initiation factor IF2/IF5
    IPR002735 Translation initiation factor IF2/IF5 domain
    IPR016189 Translation initiation factor IF2/IF5, N-terminal
    IPR016190 Translation initiation factor IF2/IF5, zinc-binding
    IPR003307 W2 domain
  • GlyGen
    P59325 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 37
    cDNA 35
    Primer pair 2

    Microarray probesets 6
Other
Accession IDs
less
MGD-MRK-9343, MGI:1261884, MGI:1919893
References
more
  • Summaries
    All 43
    Developmental Gene Expression 7
    Gene Ontology 6
    Phenotypes 7
  • Earliest
    J:50182 De Sousa PA, et al., Transient expression of a translation initiation factor is conservatively associated with embryonic gene activation in murine and bovine embryos. Biol Reprod. 1998 Oct;59(4):969-77
  • Latest
    J:335822 Capriati M, et al., Genome-wide analysis of sex-specific differences in the mother-child PELAGIE cohort exposed to organophosphate metabolites. Sci Rep. 2023 May 17;13(1):8003
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory