Emb MGI Mouse Gene Detail - MGI:95321

Symbol

Emb
Name

embigin
Synonyms

Gp70

Feature Type

protein coding gene
IDs

MGI:95321
NCBI Gene: 13723
Alliance

gene page
Transcription Start Sites

12 TSS

Sequence Map

Chr13:117357109-117410951 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 13, 65.40 cM
Mapping Data

2 experiments

SNPs within 2kb

1705 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_95321	protein coding gene	Chr13:117345072-117410951 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0020964	protein coding gene	Chr13:120138801-120193778 (+)
A/J	MGP_AJ_G0020914	protein coding gene	Chr13:115233320-115282725 (+)
AKR/J	MGP_AKRJ_G0020889	protein coding gene	Chr13:118670827-118724124 (+)
BALB/cJ	MGP_BALBcJ_G0020914	protein coding gene	Chr13:115958480-116010313 (+)
C3H/HeJ	MGP_C3HHeJ_G0020703	protein coding gene	Chr13:118513913-118571943 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0021350	protein coding gene	Chr13:123564240-123615183 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018919	protein coding gene	Chr13:110401961-110449407 (+)
CAST/EiJ	MGP_CASTEiJ_G0020222	protein coding gene	Chr13:118305205-118357876 (+)
CBA/J	MGP_CBAJ_G0020665	protein coding gene	Chr13:128381589-128437093 (+)
DBA/2J	MGP_DBA2J_G0020788	protein coding gene	Chr13:114894294-114944458 (+)
FVB/NJ	MGP_FVBNJ_G0020772	protein coding gene	Chr13:113544159-113598761 (+)
LP/J	MGP_LPJ_G0020864	protein coding gene	Chr13:120096267-120154929 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020800	protein coding gene	Chr13:128749889-128805248 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021386	protein coding gene	Chr13:118157171-118217909 (+)
PWK/PhJ	MGP_PWKPhJ_G0019975	protein coding gene	Chr13:113758148-113807881 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0019797	protein coding gene	Chr13:114516935-114568837 (+)
WSB/EiJ	MGP_WSBEiJ_G0020280	protein coding gene	Chr13:118834940-118889404 (+)

Human Ortholog

EMB, embigin

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

EMB, embigin
Synonyms

GP70
Links

HGNC:30465

NCBI Gene ID: 133418

neXtProt AC: NX_Q6PCB8

UniProt: Q6PCB8
Chr Location

5q11.1; chr5:50396192-50443345 (-) GRCh38

MGI Vertebrate Homology

Emb stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: EMB
Gene Tree

Emb

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Phenotype Summary

15 phenotypes from 2 alleles in 2 genetic backgrounds
19 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

45
Endonuclease-mediated

5
Gene trapped

36
Targeted

4
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

38 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele display partial prenatal and postnatal lethality with delayed lung development and prenatal growth retardation.

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All GO Annotations

12
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1287
Tissues

101
cDNA Data

34
Literature Summary

16

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase emb

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All Sequences

57
RefSeq

2
UniProt

5
CCDS

CCDS26791.1

Ensembl

ENSMUSG00000021728 (Evidence)
NCBI Gene

13723

			Length	Strain/Species	Flank
genomic	13723	NCBI Gene Model \| MGI Sequence Detail	53843	C57BL/6J	± kb
transcript	NM_010330	RefSeq \| MGI Sequence Detail	2622	C57BL/6
polypeptide	P21995	UniProt \| EBI \| MGI Sequence Detail	330	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000007048 embigin

(term hierarchy)
InterPro Domains

IPR013098 Immunoglobulin I-set

IPR007110 Immunoglobulin-like domain

IPR036179 Immunoglobulin-like domain superfamily

IPR013783 Immunoglobulin-like fold

IPR003599 Immunoglobulin subtype
GlyGen

P21995 9 sites, 18 N-linked glycans (7 sites)

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All nucleic 39

cDNA 37

Other 2

Microarray probesets 5

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MGD-MRK-10219, MGD-MRK-9364, MGI:2145318, MGI:95795

Summaries

All 67

Developmental Gene Expression 16

Gene Ontology 4

Phenotypes 19
Earliest

J:15311 Ozawa M, et al., A teratocarcinoma glycoprotein carrying a developmentally regulated carbohydrate marker is a member of the immunoglobulin gene superfamily. J Biol Chem. 1988 Mar 5;263(7):3059-62
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Emb:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr121216	Chr13:117356842-117356870 (+)	-253 bp
Tssr121217	Chr13:117357120-117357173 (+)	38 bp
Tssr121218	Chr13:117357245-117357257 (+)	142 bp
Tssr121219	Chr13:117357273-117357290 (+)	173 bp
Tssr121221	Chr13:117371157-117371161 (+)	14,050 bp
Tssr121222	Chr13:117372559-117372560 (+)	15,451 bp
Tssr121223	Chr13:117381984-117381987 (+)	24,877 bp
Tssr121224	Chr13:117385970-117385982 (+)	28,867 bp
Tssr121225	Chr13:117386234-117386255 (+)	29,136 bp
Tssr121226	Chr13:117387122-117387142 (+)	30,023 bp
Tssr121228	Chr13:117408574-117408612 (+)	51,484 bp
Tssr121229	Chr13:117409833-117409869 (+)	52,742 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/17/2024 MGI 6.24