Eno2 MGI Mouse Gene Detail - MGI:95394 - enolase 2, gamma neuronal

Symbol

Eno2
Name

enolase 2, gamma neuronal
Synonyms

D6Ertd375e, Eno-2, NSE

Feature Type

protein coding gene
IDs

MGI:95394
NCBI Gene: 13807
Alliance

gene page
Transcription Start Sites

11 TSS

Sequence Map

Chr6:124737018-124746489 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 6, 59.17 cM
Mapping Data

7 experiments

SNPs within 2kb

234 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_95394	protein coding gene	Chr6:124737016-124746636 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0031266	protein coding gene	Chr6:128064479-128073819 (-)
A/J	MGP_AJ_G0031236	protein coding gene	Chr6:123251092-123260715 (-)
AKR/J	MGP_AKRJ_G0031164	protein coding gene	Chr6:126609668-126619291 (-)
BALB/cJ	MGP_BALBcJ_G0031244	protein coding gene	Chr6:122850804-122860192 (-)
C3H/HeJ	MGP_C3HHeJ_G0030967	protein coding gene	Chr6:126660981-126670406 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0031700	protein coding gene	Chr6:131453802-131463370 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0028850	protein coding gene	Chr6:120438364-120447629 (-)
CAST/EiJ	MGP_CASTEiJ_G0030348	protein coding gene	Chr6:126862870-126873723 (-)
CBA/J	MGP_CBAJ_G0030928	protein coding gene	Chr6:136482958-136493495 (-)
DBA/2J	MGP_DBA2J_G0031084	protein coding gene	Chr6:122176527-122185858 (-)
FVB/NJ	MGP_FVBNJ_G0031034	protein coding gene	Chr6:121080545-121089763 (-)
LP/J	MGP_LPJ_G0031164	protein coding gene	Chr6:128240354-128250085 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0031072	protein coding gene	Chr6:140537065-140547002 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0031735	protein coding gene	Chr6:126501172-126510554 (-)
PWK/PhJ	MGP_PWKPhJ_G0030063	protein coding gene	Chr6:120404966-120415026 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0029892	protein coding gene	Chr6:124578688-124588914 (-)
WSB/EiJ	MGP_WSBEiJ_G0030433	protein coding gene	Chr6:126862405-126873110 (-)

Human Ortholog

ENO2, enolase 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ENO2, enolase 2
Synonyms

HEL-S-279, NSE
Links

HGNC:3353

NCBI Gene ID: 2026

neXtProt AC: NX_P09104

UniProt: P09104
Chr Location

12p13.31; chr12:6913745-6923698 (+) GRCh38

MGI Vertebrate Homology

Eno2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ENO2
Protein SuperFamily

Enolase
Gene Tree

Eno2

Diseases

1 with human ENO2 associations

				Human Disease	Mouse Models
				prostate cancer IDs prostate cancer DOID:10283 DOID:514 ICD10CM:C61 ICD9CM:185 KEGG:05215 MESH:D011471 NCI:C3343 NCI:C7378 OMIM:176807 OMIM:300147 OMIM:300704 OMIM:601518 OMIM:602759 OMIM:608656 OMIM:608658 OMIM:609299 OMIM:609558 OMIM:610321 OMIM:610997 OMIM:611100 OMIM:611868 OMIM:611928 OMIM:611955 OMIM:611958 OMIM:611959 ORDO:1331 UMLS_CUI:C0033578 UMLS_CUI:C0376358

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
29 phenotypes from multigenic genotypes
1 images
33 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

14
Endonuclease-mediated

11
Gene trapped

2
Targeted

1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

55 strains or lines available
Recombinase Activity

Comparison Matrix Gene Expression + Recombinase Activity

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All GO Annotations

30
GO References

12

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1062
Tissues

206
cDNA Data

76
Literature Summary

46

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

ZFIN eno2

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All Sequences

91
RefSeq

22
UniProt

10
CCDS

CCDS20527.1, CCDS80609.1

Ensembl

ENSMUSG00000004267 (Evidence)
NCBI Gene

13807

			Length	Strain/Species	Flank
genomic	13807	NCBI Gene Model \| MGI Sequence Detail	9472	C57BL/6J	± kb
transcript	NM_001409688	RefSeq \| MGI Sequence Detail	3219	ZRU/MplStud
polypeptide	P17183	UniProt \| EBI \| MGI Sequence Detail	434	Not Applicable

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UniProt

10 Sequences
Protein Ontology

PR:000007081 gamma-enolase

(term hierarchy)
EC

4.2.1.11
InterPro Domains

IPR000941 Enolase

IPR020809 Enolase, conserved site

IPR020810 Enolase, C-terminal TIM barrel domain

IPR036849 Enolase-like, C-terminal domain superfamily

IPR029017 Enolase-like, N-terminal

IPR020811 Enolase, N-terminal
GlyGen

P17183 1 site, 1 N-linked glycan (1 site)

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All nucleic 89

Genomic 4

cDNA 76

Primer pair 9

Microarray probesets 2

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MGD-MRK-9504, MGD-MRK-9507, MGI:1196312, MGI:2141477

Summaries

All 117

Developmental Gene Expression 46

Gene Ontology 12

Phenotypes 33
Earliest

J:8559 Lazar M, et al., Isolation of murine neuron-specific and non-neuronal enolase cDNA clones. Biochem Biophys Res Commun. 1986 Nov 26;141(1):271-7
Latest

J:349892 Matsumoto M, et al., Neuraminidase inhibition promotes the collective migration of neurons and recovery of brain function. EMBO Mol Med. 2024 Jun;16(6):1228-1253

TSS for Eno2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr63161	Chr6:124746511-124746533 (-)	-33 bp
Tssr63160	Chr6:124746468-124746500 (-)	5 bp
Tssr63159	Chr6:124746445-124746464 (-)	34 bp
Tssr63158	Chr6:124745293-124745343 (-)	1,171 bp
Tssr63157	Chr6:124743094-124743112 (-)	3,386 bp
Tssr63156	Chr6:124740028-124740039 (-)	6,455 bp
Tssr63155	Chr6:124739685-124739699 (-)	6,797 bp
Tssr63154	Chr6:124738298-124738310 (-)	8,185 bp
Tssr63153	Chr6:124738246-124738256 (-)	8,238 bp
Tssr63152	Chr6:124737788-124737803 (-)	8,693 bp
Tssr63151	Chr6:124737470-124737485 (-)	9,011 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24