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Epo Gene Detail
Summary
  • Symbol
    Epo
  • Name
    erythropoietin
  • Feature Type
    protein coding gene
  • IDs
    MGI:95407
    NCBI Gene: 13856
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    Chr5:137481282-137484078 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 76.50 cM, cytoband G
  • Mapping Data
    36 experiments
Strain
Comparison
more
  • SNPs within 2kb
    165 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    4
  • RFLP
    6
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95407
 protein coding gene Chr5:137481282-137531504 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030227
 protein coding gene Chr5:142242174-142301324 (-)
A/J MGP_AJ_G0030195
 protein coding gene Chr5:136044113-136094272 (-)
AKR/J MGP_AKRJ_G0030128
 protein coding gene Chr5:140462208-140515648 (-)
BALB/cJ MGP_BALBcJ_G0030205
 protein coding gene Chr5:137413163-137463870 (-)
C3H/HeJ MGP_C3HHeJ_G0029921
 protein coding gene Chr5:141110855-141165021 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030657
 protein coding gene Chr5:147505631-147558821 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027875
 protein coding gene Chr5:130287697-130336637 (-)
CAST/EiJ MGP_CASTEiJ_G0029331
 protein coding gene Chr5:140519835-140570976 (-)
CBA/J MGP_CBAJ_G0029891
 protein coding gene Chr5:153364072-153426773 (-)
DBA/2J MGP_DBA2J_G0030042
 protein coding gene Chr5:135946904-135997718 (-)
FVB/NJ MGP_FVBNJ_G0029997
 protein coding gene Chr5:135153895-135206844 (-)
LP/J MGP_LPJ_G0030131
 protein coding gene Chr5:142704744-142758956 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030029
 protein coding gene Chr5:156195512-156252084 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030698
 protein coding gene Chr5:140316897-140368862 (-)
PWK/PhJ MGP_PWKPhJ_G0029044
 protein coding gene Chr5:135031306-135084876 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028880
 protein coding gene Chr5:137873150-137931283 (-)
WSB/EiJ MGP_WSBEiJ_G0029404
 protein coding gene Chr5:141039237-141095646 (-)



Homology
more
  • Human Ortholog
    EPO, erythropoietin
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    EPO, erythropoietin
  • Synonyms
    DBAL, ECYT5, EP, MVCD2
  • Links
    NCBI Gene ID: 2056
    neXtProt AC: NX_P01588
    UniProt: P01588

  • Chr Location
    7q22.1; chr7:100720468-100723700 (+)  GRCh38
  • MGI Vertebrate Homology
    Epo stringent orthology
    1 human;1 mouse;1 rat;2 zebrafish
  • HCOP
    vertebrate homology predictions: EPO
  • Protein SuperFamily
    EPO
  • Gene Tree
    Epo
Human Diseases
more
  • Diseases
    19 with human EPO associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
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IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    34 phenotypes from 3 alleles in 6 genetic backgrounds
    7 phenotypes from multigenic genotypes
    3 images
    32 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation exhibit reduced primitive erythropoiesis and die around embryonic day 13 due to impaired fetal liver erythropoiesis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    80
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    956
  • Tissues
    116
  • cDNA Data
    9
  • Literature Summary
    64
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 13856 NCBI Gene Model | MGI Sequence Detail 2797 C57BL/6J ±  kb
    transcript NM_007942 RefSeq | MGI Sequence Detail 715 Not Specified  
    polypeptide P07321 UniProt | EBI | MGI Sequence Detail 192 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 45
      Genomic 9
      cDNA 10
      Primer pair 19
      Other 7

      Microarray probesets 1
    Other
    Accession IDs
    less
    MGD-MRK-9566
    References
    more
    • Summaries
      All 252
      Developmental Gene Expression 64
      Gene Ontology 12
      Phenotypes 32
    • Earliest
      J:8454 McDonald JD, et al., Cloning, sequencing, and evolutionary analysis of the mouse erythropoietin gene. Mol Cell Biol. 1986 Mar;6(3):842-8
    • Latest
      J:352298 Marrow JP, et al., Cardiomyocyte crosstalk with endothelium modulates cardiac structure, function, and ischemia-reperfusion injury susceptibility through erythropoietin. Front Physiol. 2024;15:1397049
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory