Erbb3 MGI Mouse Gene Detail - MGI:95411 - erb-b2 receptor tyrosine kinase 3

Symbol

Erbb3
Name

erb-b2 receptor tyrosine kinase 3
Synonyms

Erbb-3, Erbb3r, HER3

Feature Type

protein coding gene
IDs

MGI:95411
NCBI Gene: 13867
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr10:128403392-128425504 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 77.10 cM
Mapping Data

8 experiments

SNPs within 2kb

555 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_95411	protein coding gene	Chr10:128403392-128425521 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0017873	protein coding gene	Chr10:132321070-132343192 (-)
A/J	MGP_AJ_G0017848	protein coding gene	Chr10:127007848-127029986 (-)
AKR/J	MGP_AKRJ_G0017811	protein coding gene	Chr10:130725171-130747481 (-)
BALB/cJ	MGP_BALBcJ_G0017812	protein coding gene	Chr10:127381670-127403748 (-)
C3H/HeJ	MGP_C3HHeJ_G0017635	protein coding gene	Chr10:130887568-130909661 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0018267	protein coding gene	Chr10:136800462-136823573 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015945	protein coding gene	Chr10:120928075-120949982 (-)
CAST/EiJ	MGP_CASTEiJ_G0017196	protein coding gene	Chr10:131604636-131629520 (-)
CBA/J	MGP_CBAJ_G0017605	protein coding gene	Chr10:142362821-142387096 (-)
DBA/2J	MGP_DBA2J_G0017711	protein coding gene	Chr10:126065189-126087509 (-)
FVB/NJ	MGP_FVBNJ_G0017706	protein coding gene	Chr10:124988112-125011449 (-)
LP/J	MGP_LPJ_G0017785	protein coding gene	Chr10:132907979-132931362 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017734	protein coding gene	Chr10:144946180-144970863 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018307	protein coding gene	Chr10:130827711-130850955 (-)
PWK/PhJ	MGP_PWKPhJ_G0016981	protein coding gene	Chr10:126326880-126350058 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0016770	protein coding gene	Chr10:129940361-129962964 (-)
WSB/EiJ	MGP_WSBEiJ_G0017255	protein coding gene	Chr10:131044608-131067194 (-)

Human Ortholog

ERBB3, erb-b2 receptor tyrosine kinase 3

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ERBB3, erb-b2 receptor tyrosine kinase 3
Synonyms

c-erbB-3, c-erbB3, ErbB-3, erbB3-S, FERLK, HER3, LCCS2, MDA-BF-1, p180-ErbB3, p45-sErbB3, p85-sErbB3, VSCN1
Links

HGNC:3431

NCBI Gene ID: 2065

neXtProt AC: NX_P21860

UniProt: P21860
Chr Location

12q13.2; chr12:56076799-56103505 (+) GRCh38

MGI Vertebrate Homology

Erbb3 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: ERBB3
Protein SuperFamily

TyrPK_EGF-R
Gene Tree

Erbb3

Diseases

4 with human ERBB3 associations

				Human Disease	Mouse Models
				lethal congenital contracture syndrome 2 IDs lethal congenital contracture syndrome 2 DOID:0060560 MESH:C564369 OMIM:607598 ORDO:137776
				lung adenocarcinoma IDs lung adenocarcinoma DOID:3910 DOID:4826 EFO:0000571 MESH:D000077192 NCI:C27745 NCI:C3512 UMLS_CUI:C0152013 UMLS_CUI:C1335060
				lung non-small cell carcinoma IDs lung non-small cell carcinoma DOID:3908 EFO:0003060 KEGG:05223 MESH:D002289 NCI:C2926 UMLS_CUI:C0007131
				neuronal intestinal dysplasia type A IDs neuronal intestinal dysplasia type A DOID:0080679 OMIM:243180

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

86 phenotypes from 10 alleles in 13 genetic backgrounds
16 phenotypes from multigenic genotypes
52 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

29
Chemically induced (ENU)

2
Endonuclease-mediated

3
Gene trapped

11
Targeted

13
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

48 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygotes for targeted null mutations exhibit a lack of Schwann-cell precursors leading to loss of sensory and motor neurons, hypoplasia of the primary sympathetic ganglion chain, cardiac defects, impaired brain development, and embryonic lethality.

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All GO Annotations

88
GO References

21

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1506
Tissues

261
cDNA Data

112
Literature Summary

112

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase erbb3

ZFIN erbb3a, erbb3b

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All Sequences

40
RefSeq

2
UniProt

2
CCDS

CCDS24283.1

Ensembl

ENSMUSG00000018166 (Evidence)
NCBI Gene

13867

			Length	Strain/Species	Flank
genomic	13867	NCBI Gene Model \| MGI Sequence Detail	22113	C57BL/6J	± kb
transcript	NM_010153	RefSeq \| MGI Sequence Detail	5999	Not Specified
polypeptide	Q61526	UniProt \| EBI \| MGI Sequence Detail	1339	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000007159 receptor tyrosine-protein kinase erbB-3

(term hierarchy)
EC

2.7.10.1
InterPro Domains

IPR006211 Furin-like cysteine-rich domain

IPR006212 Furin-like repeat

IPR009030 Growth factor receptor cysteine-rich domain superfamily

IPR032778 Growth factor receptor domain 4

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR000494 Receptor L-domain

IPR036941 Receptor L-domain superfamily

IPR050122 Receptor Tyrosine Kinase

IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain

IPR008266 Tyrosine-protein kinase, active site

IPR020635 Tyrosine-protein kinase, catalytic domain

IPR016245 Tyrosine protein kinase, EGF/ERB/XmrK receptor
GlyGen

Q61526 10 sites, 8 N-linked glycans (5 sites)

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All nucleic 138

Genomic 4

cDNA 114

Primer pair 8

Other 12

Microarray probesets 5

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MGD-MRK-9572, MGD-MRK-9574, MGI:1098642, MGI:2143908

Summaries

All 232

Developmental Gene Expression 112

Gene Ontology 21

Phenotypes 52
Earliest

J:18117 Kraus MH, et al., Isolation and characterization of ERBB3, a third member of the ERBB/epidermal growth factor receptor family: evidence for overexpression in a subset of human mammary tumors. Proc Natl Acad Sci U S A. 1989 Dec;86(23):9193-7
Latest

J:353621 Patel VN, et al., Specific 3-O-sulfated heparan sulfate domains regulate salivary gland basement membrane metabolism and epithelial differentiation. Nat Commun. 2024 Aug 31;15(1):7584

TSS for Erbb3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr99904	Chr10:128425794-128425815 (-)	-301 bp
Tssr99903	Chr10:128425548-128425563 (-)	-52 bp
Tssr99902	Chr10:128425519-128425542 (-)	-27 bp
Tssr99901	Chr10:128425491-128425511 (-)	3 bp
Tssr99900	Chr10:128419626-128419669 (-)	5,856 bp
Tssr99899	Chr10:128414338-128414374 (-)	11,148 bp
Tssr99898	Chr10:128404534-128404557 (-)	20,958 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24