Esd MGI Mouse Gene Detail - MGI:95421 - esterase D/formylglutathione hydrolase

Symbol

Esd
Name

esterase D/formylglutathione hydrolase
Synonyms

Es-10, Es10, Esd

Feature Type

protein coding gene
IDs

MGI:95421
NCBI Gene: 13885
Alliance

gene page
Transcription Start Sites

16 TSS

Sequence Map

Chr14:74969737-74988205 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 14, 39.38 cM, cytoband D2-E2
Mapping Data

44 experiments

SNPs within 2kb

753 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_95421	protein coding gene	Chr14:74969591-74988205 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0021563	protein coding gene	Chr14:69521036-69544714 (+)
A/J	MGP_AJ_G0021521	protein coding gene	Chr14:67978125-67996131 (+)
AKR/J	MGP_AKRJ_G0021498	protein coding gene	Chr14:70003102-70021509 (+)
BALB/cJ	MGP_BALBcJ_G0021528	protein coding gene	Chr14:67770975-67789563 (+)
C3H/HeJ	MGP_C3HHeJ_G0021305	protein coding gene	Chr14:69740056-69758466 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0021968	protein coding gene	Chr14:72567146-72585686 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019506	protein coding gene	Chr14:65628212-65647313 (+)
CAST/EiJ	MGP_CASTEiJ_G0020822	protein coding gene	Chr14:66389344-66407861 (+)
CBA/J	MGP_CBAJ_G0021273	protein coding gene	Chr14:74903015-74921420 (+)
DBA/2J	MGP_DBA2J_G0021396	protein coding gene	Chr14:67397358-67416357 (+)
FVB/NJ	MGP_FVBNJ_G0021374	protein coding gene	Chr14:66725352-66743798 (+)
LP/J	MGP_LPJ_G0021466	protein coding gene	Chr14:70684973-70706478 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021401	protein coding gene	Chr14:73693181-73711650 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021991	protein coding gene	Chr14:69283578-69302438 (+)
PWK/PhJ	MGP_PWKPhJ_G0020565	protein coding gene	Chr14:64125107-64145769 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0020401	protein coding gene	Chr14:65234293-65252808 (+)
WSB/EiJ	MGP_WSBEiJ_G0020875	protein coding gene	Chr14:69616787-69638849 (+)

Human Ortholog

ESD, esterase D

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ESD, esterase D
Synonyms

FGH
Links

HGNC:3465

NCBI Gene ID: 2098

neXtProt AC: NX_P10768

UniProt: P10768
Chr Location

13q14.2; chr13:46771256-46797700 (-) GRCh38

MGI Vertebrate Homology

Esd stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ESD
Gene Tree

Esd

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

15
Chemically induced (other)

1
Endonuclease-mediated

4
Gene trapped

7
Spontaneous

1
Targeted

2
Genomic Mutations

1 involving Esd
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

26 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

10
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

808
Tissues

99
cDNA Data

234
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase esd

ZFIN esd

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All Sequences

66
RefSeq

8
UniProt

8
CCDS

CCDS36975.1, CCDS70603.1

Ensembl

ENSMUSG00000021996 (Evidence)
NCBI Gene

13885

			Length	Strain/Species	Flank
genomic	ENSMUSG00000021996	Ensembl Gene Model \| MGI Sequence Detail	18469	C57BL/6J	± kb
transcript	ENSMUST00000176957	Ensembl \| MGI Sequence Detail	1117	Not Applicable
polypeptide	ENSMUSP00000135394	Ensembl \| MGI Sequence Detail	295	Not Applicable

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UniProt

8 Sequences
Protein Ontology

PR:000007198 S-formylglutathione hydrolase

(term hierarchy)
EC

3.1.2.12
InterPro Domains

IPR029058 Alpha/Beta hydrolase fold

IPR000801 Esterase-like

IPR014186 S-formylglutathione hydrolase
GlyGen

Q9R0P3 1 site, 1 O-linked glycan (1 site)

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All nucleic 236

cDNA 235

Other 1

Microarray probesets 6

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MGD-MRK-9589, MGD-MRK-9622, MGD-MRK-9651

Summaries

All 90

Developmental Gene Expression 3

Gene Ontology 10

Phenotypes 13
Earliest

J:5630 Peters J, et al., Polymorphism of esterase-10 in Mus musculus. Biochem Genet. 1976 Feb;14(1-2):119-25
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Esd:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr126580	Chr14:74969742-74969814 (+)	41 bp
Tssr126581	Chr14:74969830-74969841 (+)	99 bp
Tssr126582	Chr14:74969853-74969864 (+)	122 bp
Tssr126583	Chr14:74970415-74970426 (+)	684 bp
Tssr126584	Chr14:74970866-74970876 (+)	1,134 bp
Tssr126585	Chr14:74970896-74970911 (+)	1,167 bp
Tssr126586	Chr14:74971086-74971112 (+)	1,362 bp
Tssr126587	Chr14:74971118-74971131 (+)	1,388 bp
Tssr126588	Chr14:74971373-74971389 (+)	1,644 bp
Tssr126589	Chr14:74972278-74972290 (+)	2,547 bp
Tssr126590	Chr14:74973081-74973103 (+)	3,355 bp
Tssr126591	Chr14:74973129-74973134 (+)	3,395 bp
Tssr126592	Chr14:74974686-74974690 (+)	4,951 bp
Tssr126593	Chr14:74981649-74981659 (+)	11,917 bp
Tssr126594	Chr14:74982985-74982997 (+)	13,254 bp
Tssr126595	Chr14:74984205-74984230 (+)	14,481 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/17/2024 MGI 6.24