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Etl4 Gene Detail
Summary
  • Symbol
    Etl4
  • Name
    enhancer trap locus 4
  • Synonyms
    6620402G01Rik, 9430077C05Rik, E330027G05Rik, Etl-4, Sickle tail, Skt
  • Feature Type
    protein coding gene
  • IDs
    MGI:95454
    NCBI Gene: 208618
  • Alliance
    gene page
  • Transcription Start Sites
    35 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:19915018-20815346 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 14.27 cM, cytoband A3
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    27451 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95454
 protein coding gene Chr2:19914591-20815524 (+)
129S1/SvImJ MGP_129S1SvImJ_G0025385
 protein coding gene Chr2:17669514-18590502 (+)
A/J MGP_AJ_G0025363
 protein coding gene Chr2:16938885-17848902 (+)
AKR/J MGP_AKRJ_G0025331
 protein coding gene Chr2:17551728-18489400 (+)
BALB/cJ MGP_BALBcJ_G0025358
 protein coding gene Chr2:16999526-17901339 (+)
C3H/HeJ MGP_C3HHeJ_G0025118
 protein coding gene Chr2:17441081-18365591 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025801
 protein coding gene Chr2:18151983-19138555 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023216
 protein coding gene Chr2:16298889-17148742 (+)
CAST/EiJ MGP_CASTEiJ_G0024582
 protein coding gene Chr2:17414111-18327394 (+)
CBA/J MGP_CBAJ_G0025097
 protein coding gene Chr2:18920233-19905470 (+)
DBA/2J MGP_DBA2J_G0025229
 protein coding gene Chr2:16882431-17769114 (+)
FVB/NJ MGP_FVBNJ_G0025192
 protein coding gene Chr2:16683315-17561416 (+)
LP/J MGP_LPJ_G0025316
 protein coding gene Chr2:17496585-18436597 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0025223
 protein coding gene Chr2:18882956-19859160 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025859
 protein coding gene Chr2:17469941-18391760 (+)
PWK/PhJ MGP_PWKPhJ_G0024331
 protein coding gene Chr2:16767741-17632963 (+)
SPRET/EiJ MGP_SPRETEiJ_G0024131
 protein coding gene Chr2:17629344-18586196 (+)
WSB/EiJ MGP_WSBEiJ_G0024652
 protein coding gene Chr2:17553108-18462446 (+)



Homology
more
  • Human Ortholog
    KIAA1217, KIAA1217
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KIAA1217, KIAA1217
  • Synonyms
    ETL4, SKT
  • Links
    NCBI Gene ID: 56243
    neXtProt AC: NX_Q5T5P2
    UniProt: Q5T5P2

  • Chr Location
    10p12.2-p12.1; chr10:23694727-24547848 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 3 alleles in 5 genetic backgrounds
    20 phenotypes from multigenic genotypes
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a gene-trapped allele display malformations of the notochord and caudal vertebrae and may exhibit caudal tail kinks. Mice homozygous for another gene-trapped allele have malformed caudal vertebrae and intervertebral disk abnormalities; about half display kinked tails.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    6
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    991
  • Tissues
    137
  • cDNA Data
    20
  • Literature Summary
    14
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 208618 NCBI Gene Model | MGI Sequence Detail 900329 C57BL/6J ±  kb
    transcript NM_001369134 RefSeq | MGI Sequence Detail 7511 ZRU/MplStud  
    polypeptide A2AQ25 UniProt | EBI | MGI Sequence Detail 1946 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      10 Sequences
    • Protein Ontology
      PR:000014910 sickle tail protein
      (term hierarchy)
    • InterPro Domains
      IPR022782 Actin interacting protein 3-like, C-terminal
      IPR051825 SRC Kinase Signaling Inhibitor
    • GlyGen
      A2AQ25 13 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (12 sites)
    Molecular
    Reagents
    less
    • All nucleic 44
      cDNA 28
      Primer pair 14
      Other 2

      Microarray probesets 9
    Other
    Accession IDs
    less
    MGD-MRK-9659, MGD-MRK-9662, MGI:1922998, MGI:1924547, MGI:2384779, MGI:2442648
    References
    more
    • Summaries
      All 59
      Developmental Gene Expression 14
      Gene Ontology 5
      Phenotypes 23
    • Earliest
      J:14930 O'Kane CJ, et al., Detection in situ of genomic regulatory elements in Drosophila. Proc Natl Acad Sci U S A. 1987 Dec;84(24):9123-7
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory