Ets1 Gene Detail

Summary

• Symbol
  Ets1
• Name
  E26 avian leukemia oncogene 1, 5' domain
• Synonyms
  Ets-1, MGC:18571, p42Ets-1, p51Ets-1, Tpl1, vs

• Feature Type
  protein coding gene
• IDs
  MGI:95455
  NCBI Gene: 23871
• Alliance
  gene page
• Transcription Start Sites
  41 TSS
• Candidate for QTL
  3 QTL

Location &
Maps

• Sequence Map
  Chr9:32547517-32669116 bp, + strand

  From Ensembl annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 9, 17.97 cM
• Mapping Data
  41 experiments

Strain
Comparison

• SNPs within 2kb
  3503 from dbSNP Build 142
• Strain Annotations
  18
• RFLP
  8

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_95455	protein coding gene	Chr9:32547501-32669116 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0034526	protein coding gene	Chr9:30397928-30528283 (+)
A/J	MGP_AJ_G0034504	protein coding gene	Chr9:29612570-29736683 (+)
AKR/J	MGP_AKRJ_G0034430	protein coding gene	Chr9:30256319-30382218 (+)
BALB/cJ	MGP_BALBcJ_G0034495	protein coding gene	Chr9:29503761-29626500 (+)
C3H/HeJ	MGP_C3HHeJ_G0034207	protein coding gene	Chr9:30602504-30729745 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0035016	protein coding gene	Chr9:31431328-31554781 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0031946	protein coding gene	Chr9:28402892-28523912 (+)
CAST/EiJ	MGP_CASTEiJ_G0033530	protein coding gene	Chr9:30461731-30605430 (+)
CBA/J	MGP_CBAJ_G0034181	protein coding gene	Chr9:32475560-32620088 (+)
DBA/2J	MGP_DBA2J_G0034338	protein coding gene	Chr9:29619051-29741121 (+)
FVB/NJ	MGP_FVBNJ_G0034281	protein coding gene	Chr9:29025945-29145643 (+)
LP/J	MGP_LPJ_G0034424	protein coding gene	Chr9:30614357-30744458 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0034325	protein coding gene	Chr9:34074934-34200178 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0035036	protein coding gene	Chr9:30242963-30369292 (+)
PWK/PhJ	MGP_PWKPhJ_G0033235	protein coding gene	Chr9:29580331-29715748 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0033070	protein coding gene	Chr9:30359415-30500853 (+)
WSB/EiJ	MGP_WSBEiJ_G0033645	protein coding gene	Chr9:29994561-30124393 (+)

Homology

• Human Ortholog
  ETS1, ETS proto-oncogene 1, transcription factor

• Vertebrate Orthologs
  3

Vertebrate Orthology Source

Alliance of Genome Resources

• Human Ortholog
  ETS1, ETS proto-oncogene 1, transcription factor
  
• Synonyms
  c-ets-1, ETS-1, EWSR2, p54
• Links
  HGNC:3488

  NCBI Gene ID: 2113

  neXtProt AC: NX_P14921

  UniProt: P14921

  
  
• Chr Location
  11q24.3; chr11:128458761-128587558 (-)  GRCh38

---

• MGI Vertebrate Homology
  Ets1 stringent orthology
  1 human;1 mouse;1 rat;1 zebrafish
  
• HCOP
  vertebrate homology predictions: ETS1
• Protein SuperFamily
  Transforming_factor_C-ets
• Gene Tree
  Ets1
  

Human Diseases

• Diseases
  1 with human ETS1 associations

				Human Disease	Mouse Models
				type 1 diabetes mellitus IDs type 1 diabetes mellitus       DOID:9744 ICD10CM:E10 KEGG:04940 MESH:D003922 NCI:C2986 OMIM:222100 UMLS_CUI:C0011854

Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  55 phenotypes from 7 alleles in 8 genetic backgrounds
  18 phenotypes from multigenic genotypes
  53 phenotype references
  

• All Mutations and Alleles
  15
• Chemically induced (ENU)
  1
• Endonuclease-mediated
  5
• Spontaneous
  1
• Targeted
  8
• Incidental Mutations
  Mutagenetix , APF
• Find Mice (IMSR)
  28 strains or lines available
• Comparison Matrix
  Gene Expression + Phenotype

Homozygotes for targeted null mutations exhibit reduced numbers of peripheral CD8+ T cells, impaired TCR-mediated activation of both CD4+ and CD8+ T cells, increased numbers of IgM-secreting plasma cells, and severely impaired NK cell development. Defects in cardiac neural crest cell migration and double outlet right ventricle are additionally observed.

Gene Ontology
(GO)
Classifications

• All GO Annotations
  65
• GO References
  16

Expression

• Assay Results
  1245
• Tissues
  373
• cDNA Data
  128
• Literature Summary
  48

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas
• Other Vertebrate Links
  Xenbase ets1
  ZFIN ets1

Sequences &
Gene Models

• All Sequences
  80
• RefSeq
  14
• UniProt
  12
• CCDS
  CCDS22954.1, CCDS40572.1, CCDS90530.1

• Ensembl
  ENSMUSG00000032035 (Evidence)
• NCBI Gene
  23871

Representative Sequences			Length	Strain/Species
genomic	ENSMUSG00000032035	Ensembl Gene Model | MGI Sequence Detail	121600	C57BL/6J
transcript	ENSMUST00000238819	Ensembl | MGI Sequence Detail	2105	Not Applicable
polypeptide	ENSMUSP00000159086	Ensembl | MGI Sequence Detail	484	Not Applicable

Protein
Information

• UniProt
  12 Sequences
• Protein Ontology
  PR:000007221 protein C-ets-1
  (term hierarchy)
• PDB
  1K78, 1K79, 1K7A, 1MD0, 1MDM, 1R36, 2JV3, 2KMD, 6DA1, 6DAT
• InterPro Domains
  IPR045688 Ets1, N-terminal flanking region of Ets domain
  IPR000418 Ets domain
  IPR046328 ETS family
  IPR003118 Pointed domain
  IPR041886 Protein C-ets-1, pointed domain
  IPR013761 Sterile alpha motif/pointed domain superfamily
  IPR016311 Transforming protein C-ets
  IPR036390 Winged helix DNA-binding domain superfamily
  IPR036388 Winged helix-like DNA-binding domain superfamily

Molecular
Reagents

• All nucleic 157

  Genomic 9

  cDNA 132

  Primer pair 11

  Other 5

  
  

  Microarray probesets 9

Other
Accession IDs

MGD-MRK-15175, MGD-MRK-15200, MGD-MRK-15415, MGD-MRK-9663, MGD-MRK-9665, MGI:2142990, MGI:2143054, MGI:98794, MGI:98939

References

• Summaries
  All 222

  Developmental Gene Expression 48

  Gene Ontology 16

  Phenotypes 53
• Earliest
  J:8218 Watson DK, et al., Conserved chromosomal positions of dual domains of the ets protooncogene in cats, mice, and humans. Proc Natl Acad Sci U S A. 1986 Mar;83(6):1792-6
• Latest
  J:357517 Cao Y, et al., ETS1 deficiency in macrophages suppresses colorectal cancer progression by reducing the F4/80+TIM4+ macrophage population. Carcinogenesis. 2024 Oct 10;45(10):745-758

TSS for Ets1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr84263	Chr9:32547506-32547517 (+)	-5 bp
Tssr84264	Chr9:32547529-32547565 (+)	30 bp
Tssr84265	Chr9:32563761-32563781 (+)	16,254 bp
Tssr84266	Chr9:32563798-32563806 (+)	16,285 bp
Tssr84267	Chr9:32591041-32591051 (+)	43,529 bp
Tssr84268	Chr9:32591062-32591078 (+)	43,553 bp
Tssr84269	Chr9:32592754-32592757 (+)	45,239 bp
Tssr84270	Chr9:32606974-32606982 (+)	59,461 bp
Tssr84271	Chr9:32606988-32607001 (+)	59,478 bp
Tssr84272	Chr9:32607011-32607015 (+)	59,496 bp
Tssr84273	Chr9:32607047-32607071 (+)	59,542 bp
Tssr84274	Chr9:32607102-32607112 (+)	59,590 bp
Tssr84275	Chr9:32607301-32607391 (+)	59,829 bp
Tssr84276	Chr9:32608161-32608172 (+)	60,650 bp
Tssr84277	Chr9:32608282-32608307 (+)	60,778 bp
Tssr84278	Chr9:32609223-32609235 (+)	61,712 bp
Tssr84279	Chr9:32609543-32609570 (+)	62,040 bp
Tssr84280	Chr9:32610706-32610719 (+)	63,196 bp
Tssr84281	Chr9:32611107-32611117 (+)	63,595 bp
Tssr84282	Chr9:32611186-32611193 (+)	63,673 bp
Tssr84283	Chr9:32611566-32611594 (+)	64,063 bp
Tssr84284	Chr9:32612588-32612608 (+)	65,081 bp
Tssr84285	Chr9:32615470-32615481 (+)	67,959 bp
Tssr84286	Chr9:32616425-32616431 (+)	68,911 bp
Tssr84287	Chr9:32628055-32628057 (+)	80,539 bp
Tssr84288	Chr9:32634682-32634687 (+)	87,168 bp
Tssr84289	Chr9:32638041-32638046 (+)	90,527 bp
Tssr84290	Chr9:32639856-32639891 (+)	92,357 bp
Tssr84291	Chr9:32639897-32639904 (+)	92,384 bp
Tssr84292	Chr9:32643443-32643461 (+)	95,935 bp
Tssr84293	Chr9:32643481-32643489 (+)	95,968 bp
Tssr84294	Chr9:32649021-32649026 (+)	101,507 bp
Tssr84295	Chr9:32651330-32651334 (+)	103,815 bp
Tssr84296	Chr9:32655236-32655245 (+)	107,724 bp
Tssr84297	Chr9:32656603-32656606 (+)	109,088 bp
Tssr84298	Chr9:32656679-32656712 (+)	109,179 bp
Tssr84299	Chr9:32659222-32659239 (+)	111,714 bp
Tssr84300	Chr9:32664147-32664156 (+)	116,635 bp
Tssr84301	Chr9:32665753-32665757 (+)	118,238 bp
Tssr84302	Chr9:32665942-32665946 (+)	118,427 bp
Tssr84303	Chr9:32666056-32666062 (+)	118,542 bp

Ets1 is Candidate Gene for:

QTL	Genetic Location*	Genome Location (GRCm39)	Reference	QTL Note
Bwtq4	Chr9, syntenic		J:91835	The correlation between gene expression and dietary interaction was examined in a population of (BALB/cStCrlfC3H/Nctr x VY/WffC3Hf/Nctr-A(vy)/a)F1 animals. A/a and A/A animals were placed on a 70% (calorie restricted) or 100% (non-restricted) diet andliver mRNA levels were assessed for over 18,000 genes using DNA microarrays. Twenty-eight known genes showing statistically significant differential expression between the 70% and 100% calorie diets and A/a and A/A genotypes mapped near known diabesity QTLs. These genes may be considered further for candidate genes. On mouse Chromosome 9, Ets1 (15 cM) showed differential expression between the restricted and unrestricted diets on the A/A background and between A/a and A/A animals on both therestricted and unrestricted diets. Diabesity QTLs mapping near Ets1 are Bwtq4 (8 cM) and Obq5 (19 cM). A candidate gene for diabesity QTL Dob2 (60 cM) is Cacna2d2 (60 cM). Cacna2d2 shows differential expression between the restricted and unrestricted diets on a A/a background.
Dob2	Chr9, 59.33 cM	Chr9:86121898-120118690	J:91835	The correlation between gene expression and dietary interaction was examined in a population of (BALB/cStCrlfC3H/Nctr x VY/WffC3Hf/Nctr-A(vy)/a)F1 animals. A/a and A/A animals were placed on a 70% (calorie restricted) or 100% (non-restricted) diet andliver mRNA levels were assessed for over 18,000 genes using DNA microarrays. Twenty-eight known genes showing statistically significant differential expression between the 70% and 100% calorie diets and A/a and A/A genotypes mapped near known diabesity QTLs. These genes may be considered further for candidate genes. On mouse Chromosome 9, Ets1 (15 cM) showed differential expression between the restricted and unrestricted diets on the A/A background and between A/a and A/A animals on both therestricted and unrestricted diets. Diabesity QTLs mapping near Ets1 are Bwtq4 (8 cM) and Obq5 (19 cM). A candidate gene for diabesity QTL Dob2 (60 cM) is Cacna2d2 (60 cM). Cacna2d2 shows differential expression between the restricted and unrestricted diets on a A/a background.
Obq5	Chr9, 23.53 cM	Chr9:28503333-41799326	J:91835	The correlation between gene expression and dietary interaction was examined in a population of (BALB/cStCrlfC3H/Nctr x VY/WffC3Hf/Nctr-A(vy)/a)F1 animals. A/a and A/A animals were placed on a 70% (calorie restricted) or 100% (non-restricted) diet andliver mRNA levels were assessed for over 18,000 genes using DNA microarrays. Twenty-eight known genes showing statistically significant differential expression between the 70% and 100% calorie diets and A/a and A/A genotypes mapped near known diabesity QTLs. These genes may be considered further for candidate genes. On mouse Chromosome 9, Ets1 (15 cM) showed differential expression between the restricted and unrestricted diets on the A/A background and between A/a and A/A animals on both therestricted and unrestricted diets. Diabesity QTLs mapping near Ets1 are Bwtq4 (8 cM) and Obq5 (19 cM). A candidate gene for diabesity QTL Dob2 (60 cM) is Cacna2d2 (60 cM). Cacna2d2 shows differential expression between the restricted and unrestricted diets on a A/a background.

*cM position of peak correlated region/marker