F8a Gene Detail

Summary

• Symbol
  F8a
• Name
  factor 8-associated gene A
• Synonyms
  DXUcsf1

• Feature Type
  protein coding gene
• IDs
  MGI:95474
  NCBI Gene: 14070
• Alliance
  gene page
• Transcription Start Sites
  1 TSS

Location &
Maps

• Sequence Map
  ChrX:72271912-72274401 bp, + strand

  From NCBI annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome X, 37.29 cM
• Mapping Data
  9 experiments

Strain
Comparison

• SNPs within 2kb
  10 from dbSNP Build 142
• Strain Annotations
  17
• RFLP
  2

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_95474	protein coding gene	ChrX:72271897-72274401 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0035803	protein coding gene	ChrX:68952079-68954583 (+)
A/J	MGP_AJ_G0035784	protein coding gene	ChrX:69154074-69156578 (+)
AKR/J	MGP_AKRJ_G0035710	protein coding gene	ChrX:70977789-70980293 (+)
BALB/cJ	MGP_BALBcJ_G0035771	protein coding gene	ChrX:68211314-68213818 (+)
C3H/HeJ	MGP_C3HHeJ_G0035477	protein coding gene	ChrX:69442219-69444723 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0036302	protein coding gene	ChrX:71077208-71079712 (+)
CAROLI/EiJ	no annotation
CAST/EiJ	MGP_CASTEiJ_G0034768	protein coding gene	ChrX:54768070-54770560 (+)
CBA/J	MGP_CBAJ_G0035450	protein coding gene	ChrX:73009762-73012266 (+)
DBA/2J	MGP_DBA2J_G0035608	protein coding gene	ChrX:68637171-68639675 (+)
FVB/NJ	MGP_FVBNJ_G0035552	protein coding gene	ChrX:67966073-67968577 (+)
LP/J	MGP_LPJ_G0035694	protein coding gene	ChrX:69786415-69788919 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0035589	protein coding gene	ChrX:75576401-75578905 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0036323	protein coding gene	ChrX:68797262-68799766 (+)
PWK/PhJ	MGP_PWKPhJ_G0034467	protein coding gene	ChrX:52791950-52794454 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0034301	protein coding gene	ChrX:55682399-55684901 (+)
WSB/EiJ	MGP_WSBEiJ_G0034907	protein coding gene	ChrX:68078704-68081209 (+)

Homology

• Human Ortholog
  F8A1, coagulation factor VIII associated 1

• Vertebrate Orthologs
  5

Vertebrate Orthology Source

Alliance of Genome Resources

• Human Ortholog
  F8A1, coagulation factor VIII associated 1
  
• Synonyms
  DXS522E, F8A, HAP40
• Links
  HGNC:3547

  NCBI Gene ID: 8263

  neXtProt AC: NX_P23610

  UniProt: P23610

  
  
• Chr Location
  Xq28; chrX:154886355-154888061 (+)  GRCh38

---

• Human Ortholog
  F8A2, coagulation factor VIII associated 2
  
• Synonyms
  HAP40
• Links
  HGNC:31849

  NCBI Gene ID: 474383

  neXtProt AC: NX_P23610

  UniProt: P23610

  
  
• Chr Location
  Xq28; chrX:155382095-155383801 (+)  GRCh38

---

• Human Ortholog
  F8A3, coagulation factor VIII associated 3
  
• Synonyms
  HAP40
• Links
  HGNC:31850

  NCBI Gene ID: 474384

  neXtProt AC: NX_P23610

  UniProt: P23610

  
  
• Chr Location
  Xq28; chrX:155456914-155458620 (-)  GRCh38

---

• MGI Vertebrate Homology
  F8a stringent orthology
  3 human;1 mouse;1 rat;1 zebrafish
  
• HCOP
  vertebrate homology predictions: F8A1, F8A2, F8A3
• Gene Tree
  F8a
  

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  2 phenotype references
  

• All Mutations and Alleles
  3
• Endonuclease-mediated
  2
• Targeted
  1
• Genomic Mutations
  1 involving F8a
• Find Mice (IMSR)
  3 strains or lines available

Gene Ontology
(GO)
Classifications

• All GO Annotations
  12
• GO References
  6

Expression

• Assay Results
  780
• Tissues
  10
• cDNA Data
  20
• Literature Summary
  4

Images

Tissue x Stage Matrix

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas
• Other Vertebrate Links
  Xenbase f8a1
  ZFIN f8a

Sequences &
Gene Models

• All Sequences
  36
• RefSeq
  2
• UniProt
  2
• CCDS
  CCDS41011.1

• Ensembl
  ENSMUSG00000078317 (Evidence)
• NCBI Gene
  14070

Representative Sequences			Length	Strain/Species
genomic	14070	NCBI Gene Model | MGI Sequence Detail	2490	C57BL/6J
transcript	NM_007978	RefSeq | MGI Sequence Detail	2490	ZRU/MplStud
polypeptide	Q00558	UniProt | EBI | MGI Sequence Detail	381	Not Applicable

Protein
Information

• UniProt
  2 Sequences
• Protein Ontology
  PR:000045588 40-kDa huntingtin-associated protein
  (term hierarchy)
• InterPro Domains
  IPR039494 Factor VIII intron 22 protein
  IPR011990 Tetratricopeptide-like helical domain superfamily

Molecular
Reagents

• All nucleic 37

  Genomic 14

  cDNA 22

  Primer pair 1

  
  

  Microarray probesets 4

Other
Accession IDs

MGD-MRK-9240, MGD-MRK-9695, MGI:2147930

References

• Summaries
  All 34

  Developmental Gene Expression 4

  Gene Ontology 6

  Phenotypes 2
• Earliest
  J:10466 Levinson B, et al., A transcribed gene in an intron of the human factor VIII gene. Genomics. 1990 May;7(1):1-11
• Latest
  J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

TSS for F8a:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr161197	ChrX:72271878-72271920 (+)	-13 bp