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Fabp1 Gene Detail
Summary
  • Symbol
    Fabp1
  • Name
    fatty acid binding protein 1, liver
  • Synonyms
    Fabpl, L-FABP, MGC:13855
  • Feature Type
    protein coding gene
  • IDs
    MGI:95479
    NCBI Gene: 14080
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:71176863-71182018 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 32.14 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    223 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    4
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95479
 protein coding gene Chr6:71176811-71182018 (+)
129S1/SvImJ MGP_129S1SvImJ_G0030853
 protein coding gene Chr6:71659567-71664767 (+)
A/J MGP_AJ_G0030823
 protein coding gene Chr6:68908729-68913921 (+)
AKR/J MGP_AKRJ_G0030752
 protein coding gene Chr6:70884514-70889768 (+)
BALB/cJ MGP_BALBcJ_G0030834
 protein coding gene Chr6:68943421-68948621 (+)
C3H/HeJ MGP_C3HHeJ_G0030878
 protein coding gene Chr6:113358545-113363754 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031292
 protein coding gene Chr6:73543799-73548995 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028481
 protein coding gene Chr6:68094422-68099627 (+)
CAST/EiJ MGP_CASTEiJ_G0029943
 protein coding gene Chr6:70732505-70737695 (+)
CBA/J MGP_CBAJ_G0030521
 protein coding gene Chr6:76465579-76470788 (+)
DBA/2J MGP_DBA2J_G0030673
 protein coding gene Chr6:68280557-68285766 (+)
FVB/NJ MGP_FVBNJ_G0030626
 protein coding gene Chr6:67652179-67657375 (+)
LP/J MGP_LPJ_G0030752
 protein coding gene Chr6:71592587-71597783 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030661
 protein coding gene Chr6:79969538-79974790 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031318
 protein coding gene Chr6:70731826-70737022 (+)
PWK/PhJ MGP_PWKPhJ_G0029658
 protein coding gene Chr6:67151699-67157091 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029486
 protein coding gene Chr6:69439221-69447970 (+)
WSB/EiJ MGP_WSBEiJ_G0030024
 protein coding gene Chr6:71069529-71074735 (+)



Homology
more
  • Human Ortholog
    FABP1, fatty acid binding protein 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FABP1, fatty acid binding protein 1
  • Synonyms
    FABPL, L-FABP
  • Links
    NCBI Gene ID: 2168
    neXtProt AC: NX_P07148
    UniProt: P07148

  • Chr Location
    2p11.2; chr2:88122982-88128062 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 3 alleles in 3 genetic backgrounds
    55 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a disruption in this gene do not show any obvious morphological, behavioral, or reproductive abnormalities. Changes may be observed in lipid composition, lipid binding, or levels of lipid binding proteins.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    48
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    723
  • Tissues
    12
  • cDNA Data
    122
  • Literature Summary
    29
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14080 NCBI Gene Model | MGI Sequence Detail 5156 C57BL/6J ±  kb
    transcript NM_017399 RefSeq | MGI Sequence Detail 512 ZRU/MplStud  
    polypeptide P12710 UniProt | EBI | MGI Sequence Detail 127 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 128
      cDNA 124
      Primer pair 4

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-9706
    References
    more
    • Summaries
      All 132
      Developmental Gene Expression 29
      Gene Ontology 9
      Phenotypes 55
    • Earliest
      J:8932 Sweetser DA, et al., The human and rodent intestinal fatty acid binding protein genes. A comparative analysis of their structure, expression, and linkage relationships. J Biol Chem. 1987 Nov 25;262(33):16060-71
    • Latest
      J:348737 Newberry EP, et al., Impaired Hepatic Very Low-Density Lipoprotein Secretion Promotes Tumorigenesis and Is Accelerated with Fabp1 Deletion. Am J Pathol. 2024 Jun;194(6):958-974
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory