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Fcer1g Gene Detail
Summary
  • Symbol
    Fcer1g
  • Name
    Fc receptor, IgE, high affinity I, gamma polypeptide
  • Synonyms
    Fce1g, FcepsilonRI, FcR[g], FcR-gamma, FcRgamma, Ly-50
  • Feature Type
    protein coding gene
  • IDs
    MGI:95496
    NCBI Gene: 14127
  • Alliance
    gene page
  • Transcription Start Sites
    25 TSS
  • Candidate for QTL
    4 QTL
Location &
Maps
more
  • Sequence Map
    Chr1:171057141-171061918 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 79.23 cM
  • Mapping Data
    17 experiments
Strain
Comparison
more
  • SNPs within 2kb
    194 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95496
 protein coding gene Chr1:171057141-171061934 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016748
 protein coding gene Chr1:177010848-177015487 (-)
A/J MGP_AJ_G0016728
 protein coding gene Chr1:169811001-169815642 (-)
AKR/J MGP_AKRJ_G0016694
 protein coding gene Chr1:174898254-174902972 (-)
BALB/cJ MGP_BALBcJ_G0016689
 protein coding gene Chr1:170293618-170298268 (-)
C3H/HeJ MGP_C3HHeJ_G0016512
 protein coding gene Chr1:175143180-175147819 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017150
 protein coding gene Chr1:182893959-182898627 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014858
 protein coding gene Chr1:161491214-161495868 (-)
CAST/EiJ MGP_CASTEiJ_G0016093
 protein coding gene Chr1:174765847-174770496 (-)
CBA/J MGP_CBAJ_G0016487
 protein coding gene Chr1:189411314-189415962 (-)
DBA/2J MGP_DBA2J_G0016594
 protein coding gene Chr1:168650460-168655313 (-)
FVB/NJ MGP_FVBNJ_G0016590
 protein coding gene Chr1:166998825-167003462 (-)
LP/J MGP_LPJ_G0016665
 protein coding gene Chr1:178131448-178136091 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016617
 protein coding gene Chr1:196693671-196698318 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017187
 protein coding gene Chr1:174769236-174773883 (-)
PWK/PhJ MGP_PWKPhJ_G0015879
 protein coding gene Chr1:167872961-167877650 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015663
 protein coding gene Chr1:173553932-173558594 (-)
WSB/EiJ MGP_WSBEiJ_G0016155
 protein coding gene Chr1:174886200-174890861 (-)



Homology
more
  • Human Ortholog
    FCER1G, Fc epsilon receptor Ig
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FCER1G, Fc epsilon receptor Ig
  • Synonyms
    FCRG
  • Links
    NCBI Gene ID: 2207
    neXtProt AC: NX_P30273
    UniProt: P30273

  • Chr Location
    1q23.3; chr1:161215234-161220699 (+)  GRCh38
Human Diseases
less
  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    51 phenotypes from 3 alleles in 7 genetic backgrounds
    52 phenotypes from multigenic genotypes
    453 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit impairments in macrophage phagocytosis, NK cell-mediated antibody-coated cytotoxicity, mast cell degranulation, IgE-mediated systemic anaphylaxis, and neutrophil recruitment and migration.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    110
  • GO References
    30
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    754
  • Tissues
    32
  • cDNA Data
    29
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14127 NCBI Gene Model | MGI Sequence Detail 4778 C57BL/6J ±  kb
    transcript NM_010185 RefSeq | MGI Sequence Detail 683 ZRU/MplStud  
    polypeptide P20491 UniProt | EBI | MGI Sequence Detail 86 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000007432 high affinity immunoglobulin epsilon receptor subunit gamma
      (term hierarchy)
    • PDB
      8K7T, 8YRJ
    • InterPro Domains
      IPR042340 High affinity immunoglobulin epsilon receptor subunit gamma
      IPR003110 Phosphorylated immunoreceptor signalling ITAM
      IPR021663 T-cell surface glycoprotein CD3 zeta subunit/High affinity IgE receptor gamma subunit
    Molecular
    Reagents
    less
    • All nucleic 34
      Genomic 2
      cDNA 31
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-11993, MGD-MRK-9726, MGD-MRK-9730, MGI:2138290
    References
    more
    • Summaries
      All 532
      Developmental Gene Expression 3
      Diseases 1
      Gene Ontology 30
      Phenotypes 453
    • Earliest
      J:8413 Hibbs ML, et al., The murine Fc receptor for immunoglobulin: purification, partial amino acid sequence, and isolation of cDNA clones. Proc Natl Acad Sci U S A. 1986 Sep;83(18):6980-4
    • Latest
      J:358323 Slein MD, et al., Effector functions are required for broad and potent protection of neonatal mice with antibodies targeting HSV glycoprotein D. Cell Rep Med. 2024 Feb 20;5(2):101417
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/17/2024
    MGI 6.24     		The Jackson Laboratory