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Fcer2a Gene Detail
Summary
  • Symbol
    Fcer2a
  • Name
    Fc receptor, IgE, low affinity II, alpha polypeptide
  • Synonyms
    CD23, Fce2, FC epsilon RII, low-affinity IgE receptor, Ly-42
  • Feature Type
    protein coding gene
  • IDs
    MGI:95497
    NCBI Gene: 14128
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:3731737-3744175 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 1.92 cM, cytoband A1
  • Mapping Data
    15 experiments
Strain
Comparison
more
  • SNPs within 2kb
    394 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    3
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95497
 protein coding gene Chr8:3730280-3744175 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033316
 protein coding gene Chr8:628707-644073 (-)
A/J MGP_AJ_G0033299
 protein coding gene Chr8:598036-610605 (-)
AKR/J MGP_AKRJ_G0033230
 protein coding gene Chr8:627990-640083 (-)
BALB/cJ MGP_BALBcJ_G0033299
 protein coding gene Chr8:623815-636444 (-)
C3H/HeJ MGP_C3HHeJ_G0033013
 protein coding gene Chr8:641279-655920 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033809
 protein coding gene Chr8:674580-688632 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030782
 protein coding gene Chr8:550557-563144 (-)
CAST/EiJ MGP_CASTEiJ_G0032336
 protein coding gene Chr8:638869-651507 (-)
CBA/J MGP_CBAJ_G0032986
 protein coding gene Chr8:689520-710797 (-)
DBA/2J MGP_DBA2J_G0033140
 protein coding gene Chr8:568795-581393 (-)
FVB/NJ MGP_FVBNJ_G0033087
 protein coding gene Chr8:617674-629369 (-)
LP/J MGP_LPJ_G0033232
 protein coding gene Chr8:611626-623846 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033122
 protein coding gene Chr8:667554-679579 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033827
 protein coding gene Chr8:620859-634591 (-)
PWK/PhJ MGP_PWKPhJ_G0032046
 protein coding gene Chr8:597628-610076 (-)
SPRET/EiJ MGP_SPRETEiJ_G0031890
 protein coding gene Chr8:610534-629429 (-)
WSB/EiJ MGP_WSBEiJ_G0032449
 protein coding gene Chr8:617237-630814 (-)



Homology
more
  • Human Ortholog
    FCER2, Fc epsilon receptor II
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FCER2, Fc epsilon receptor II
  • Synonyms
    BLAST-2, CD23, CD23A, CLEC4J, FCE2, FCErII, IGEBF
  • Links
    NCBI Gene ID: 2208
    neXtProt AC: NX_P06734
    UniProt: P06734

  • Chr Location
    19p13.2; chr19:7688758-7702146 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    17 phenotypes from 6 alleles in 6 genetic backgrounds
    11 phenotypes from multigenic genotypes
    40 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for mutations in this gene are essentially normal although IgE levels or IgE mediated responses may be abnormal.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    26
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    709
  • Tissues
    3
  • cDNA Data
    18
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000005540 Ensembl Gene Model | MGI Sequence Detail 12439 C57BL/6J ±  kb
    transcript ENSMUST00000005678 Ensembl | MGI Sequence Detail 2242 Not Applicable  
    polypeptide ENSMUSP00000005678 Ensembl | MGI Sequence Detail 331 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 31
      Genomic 13
      cDNA 18

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-11984, MGD-MRK-9727, MGD-MRK-9731
    References
    more
    • Summaries
      All 105
      Developmental Gene Expression 1
      Gene Ontology 14
      Phenotypes 40
    • Earliest
      J:9944 Holmes KL, et al., Murine hematopoietic cell surface antigen expression. Immunol Today. 1988 Nov;9(11):344-50
    • Latest
      J:313926 Cichon MA, et al., Distinct Distribution of RTN1A in Immune Cells in Mouse Skin and Lymphoid Organs. Front Cell Dev Biol. 2020;8:608876
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory