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Fgf1 Gene Detail
Summary
  • Symbol
    Fgf1
  • Name
    fibroblast growth factor 1
  • Synonyms
    Fgf-1, Fgfa, fibroblast growth factor 1 (acidic)
  • Feature Type
    protein coding gene
  • IDs
    MGI:95515
    NCBI Gene: 14164
  • Alliance
    gene page
  • Transcription Start Sites
    13 TSS
  • Candidate for QTL
    2 QTL
Location &
Maps
more
  • Sequence Map
    Chr18:38971726-39062525 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 20.74 cM
  • Mapping Data
    25 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2835 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    6
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95515
 protein coding gene Chr18:38971725-39062532 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024367
 protein coding gene Chr18:37339191-37443797 (-)
A/J MGP_AJ_G0024334
 protein coding gene Chr18:36034428-36124587 (-)
AKR/J MGP_AKRJ_G0024303
 protein coding gene Chr18:37018679-37109972 (-)
BALB/cJ MGP_BALBcJ_G0024334
 protein coding gene Chr18:36110191-36192247 (-)
C3H/HeJ MGP_C3HHeJ_G0024100
 protein coding gene Chr18:37098699-37191308 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024776
 protein coding gene Chr18:38657747-38754420 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022215
 protein coding gene Chr18:36037840-36127615 (-)
CAST/EiJ MGP_CASTEiJ_G0023575
 protein coding gene Chr18:37055174-37149525 (-)
CBA/J MGP_CBAJ_G0024070
 protein coding gene Chr18:39802133-39907320 (-)
DBA/2J MGP_DBA2J_G0024200
 protein coding gene Chr18:35622004-35713252 (-)
FVB/NJ MGP_FVBNJ_G0024166
 protein coding gene Chr18:35347939-35445908 (-)
LP/J MGP_LPJ_G0024284
 protein coding gene Chr18:37382246-37475271 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024197
 protein coding gene Chr18:41014599-41113337 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024825
 protein coding gene Chr18:36908381-37001267 (-)
PWK/PhJ MGP_PWKPhJ_G0023319
 protein coding gene Chr18:35858998-35951177 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023124
 protein coding gene Chr18:37128161-37223416 (-)
WSB/EiJ MGP_WSBEiJ_G0023638
 protein coding gene Chr18:36793399-36886864 (-)



Homology
more
  • Human Ortholog
    FGF1, fibroblast growth factor 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FGF1, fibroblast growth factor 1
  • Synonyms
    AFGF, ECGF, ECGFA, ECGFB, ECGF-beta, FGF-1, FGFA, FGF-alpha, GLIO703, HBGF-1, HBGF1
  • Links
    NCBI Gene ID: 2246
    neXtProt AC: NX_P05230
    UniProt: P05230

  • Chr Location
    5q31.3; chr5:142592178-142698070 (-)  GRCh38
Human Diseases
more
  • Diseases
    5 with human FGF1 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    3 phenotypes from multigenic genotypes
    13 phenotype references
Mice homozygous for a knock-out allele are viable, breed and develop normally, and exhibit normal brain structure and normal rates of wound healing.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    84
  • GO References
    16
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1233
  • Tissues
    308
  • cDNA Data
    44
  • Literature Summary
    75
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000036585 Ensembl Gene Model | MGI Sequence Detail 90800 C57BL/6J ±  kb
transcript ENSMUST00000040647 Ensembl | MGI Sequence Detail 3981 Not Applicable  
polypeptide ENSMUSP00000045710 Ensembl | MGI Sequence Detail 155 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 85
    Genomic 12
    cDNA 51
    Primer pair 13
    Other 9

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-9760, MGD-MRK-9766, MGD-MRK-9773
References
more
  • Summaries
    All 198
    Developmental Gene Expression 75
    Gene Ontology 16
    Phenotypes 13
  • Earliest
    J:13138 Roberts E, A new mutation in the house mouse (Mus musculus). Science. 1931;74:569
  • Latest
    J:353621 Patel VN, et al., Specific 3-O-sulfated heparan sulfate domains regulate salivary gland basement membrane metabolism and epithelial differentiation. Nat Commun. 2024 Aug 31;15(1):7584
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory