Flt1 MGI Mouse Gene Detail - MGI:95558 - FMS-like tyrosine kinase 1

Symbol

Flt1
Name

FMS-like tyrosine kinase 1
Synonyms

Flt-1, sFlt1, vascular endothelial growth factor receptor-1, VEGFR-1, VEGFR1

Feature Type

protein coding gene
IDs

MGI:95558
NCBI Gene: 14254
Alliance

gene page
Transcription Start Sites

10 TSS

Sequence Map

Chr5:147498414-147662821 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 87.01 cM, cytoband G
Mapping Data

3 experiments

SNPs within 2kb

5339 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_95558	protein coding gene	Chr5:147498414-147663419 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0030391	protein coding gene	Chr5:153239322-153417102 (-)
A/J	MGP_AJ_G0030364	protein coding gene	Chr5:146733377-146901260 (-)
AKR/J	MGP_AKRJ_G0030291	protein coding gene	Chr5:151244298-151413430 (-)
BALB/cJ	MGP_BALBcJ_G0030373	protein coding gene	Chr5:147948976-148120605 (-)
C3H/HeJ	MGP_C3HHeJ_G0030087	protein coding gene	Chr5:152221203-152389205 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0030828	protein coding gene	Chr5:158843447-159036006 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0028041	protein coding gene	Chr5:141139974-141303106 (-)
CAST/EiJ	MGP_CASTEiJ_G0029489	protein coding gene	Chr5:151786890-151966819 (-)
CBA/J	MGP_CBAJ_G0030065	protein coding gene	Chr5:165502094-165689832 (-)
DBA/2J	MGP_DBA2J_G0030209	protein coding gene	Chr5:146411809-146581167 (-)
FVB/NJ	MGP_FVBNJ_G0030163	protein coding gene	Chr5:145614493-145783643 (-)
LP/J	MGP_LPJ_G0030296	protein coding gene	Chr5:153926384-154108220 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0030199	protein coding gene	Chr5:167725300-167913943 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0030858	protein coding gene	Chr5:151153206-151324763 (-)
PWK/PhJ	MGP_PWKPhJ_G0029203	protein coding gene	Chr5:145519256-145694160 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0029039	protein coding gene	Chr5:148469187-148658525 (-)
WSB/EiJ	MGP_WSBEiJ_G0029566	protein coding gene	Chr5:151965060-152139832 (-)

Human Ortholog

FLT1, fms related receptor tyrosine kinase 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

FLT1, fms related receptor tyrosine kinase 1
Synonyms

FLT, FLT-1, VEGFR-1, VEGFR1
Links

HGNC:3763

NCBI Gene ID: 2321

neXtProt AC: NX_P17948

UniProt: P17948
Chr Location

13q12.3; chr13:28300346-28495145 (-) GRCh38

MGI Vertebrate Homology

Flt1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: FLT1
Protein SuperFamily

TyrPK_CSF1-R
Gene Tree

Flt1

Diseases

4 with human FLT1 associations

				Human Disease	Mouse Models
				bronchopulmonary dysplasia IDs bronchopulmonary dysplasia DOID:11650 DOID:11651 ICD10CM:P27.1 MESH:D001997 NCI:C90599
				diabetic retinopathy IDs diabetic retinopathy DOID:8947 ICD9CM:362.0 MESH:D003930 NCI:C34538 UMLS_CUI:C0011884
				Kuhnt-Junius degeneration IDs Kuhnt-Junius degeneration DOID:10873 ICD10CM:H35.32 ICD9CM_2006:362.52 ICD9CM:362.52 UMLS_CUI:C0271084
				pre-eclampsia IDs pre-eclampsia DOID:10591 DOID:12684 ICD10CM:O14 MESH:D011225 NCI:C85021 OMIM:189800 OMIM:609402 OMIM:609403 OMIM:609404 OMIM:614592 ORDO:275555 UMLS_CUI:C0032914

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

31 phenotypes from 9 alleles in 13 genetic backgrounds
17 phenotypes from multigenic genotypes
99 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

15
Endonuclease-mediated

4
Targeted

11
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

76 strains or lines available
Comparison Matrix

Gene Expression + Phenotype
Recombinase Activity

Comparison Matrix Gene Expression + Recombinase Activity

Homozygotes for targeted null mutations exhibit an excess of hemangioblasts resulting in an overgrowth of endothelial cells, abnormalities of vascular channels and blood islands, and lethality at the mid-somite developmental stage.

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All GO Annotations

108
GO References

24

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1176
Tissues

216
cDNA Data

26
Literature Summary

212

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA FLT1

ZFIN flt1

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All Sequences

74
RefSeq

17
UniProt

9
CCDS

CCDS19879.1, CCDS90022.1

Ensembl

ENSMUSG00000029648 (Evidence)
NCBI Gene

14254

			Length	Strain/Species	Flank
genomic	ENSMUSG00000029648	Ensembl Gene Model \| MGI Sequence Detail	164408	C57BL/6J	± kb
transcript	ENSMUST00000031653	Ensembl \| MGI Sequence Detail	6895	Not Applicable
polypeptide	ENSMUSP00000031653	Ensembl \| MGI Sequence Detail	1333	Not Applicable

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UniProt

9 Sequences
Protein Ontology

PR:000007563 vascular endothelial growth factor receptor 1

(term hierarchy)
EC

2.7.10.1
InterPro Domains

IPR013151 Immunoglobulin

IPR013098 Immunoglobulin I-set

IPR007110 Immunoglobulin-like domain

IPR036179 Immunoglobulin-like domain superfamily

IPR013783 Immunoglobulin-like fold

IPR003599 Immunoglobulin subtype

IPR003598 Immunoglobulin subtype 2

IPR042495 Platelet-derived growth factor receptor-like protein

IPR017441 Protein kinase, ATP binding site

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR050122 Receptor Tyrosine Kinase

IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain

IPR008266 Tyrosine-protein kinase, active site

IPR020635 Tyrosine-protein kinase, catalytic domain

IPR001824 Tyrosine-protein kinase, receptor class III, conserved site

IPR009135 Vascular endothelial growth factor receptor 1 (VEGFR1)

IPR041348 VEGFR-2, transmembrane domain
GlyGen

P35969 14 sites, 7 N-linked glycans (11 sites), 1 O-linked glycan (1 site)

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All nucleic 75

Genomic 1

cDNA 29

Primer pair 30

Other 15

Microarray probesets 8

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MGD-MRK-9832, MGD-MRK-9836, MGI:2140833

Summaries

All 400

Developmental Gene Expression 212

Gene Ontology 24

Phenotypes 99
Earliest

J:36463 Raz V, et al., PCR-based identification of new receptors: molecular cloning of a receptor for fibroblast growth factors. Oncogene. 1991 May;6(5):753-60
Latest

J:352471 Yoshida S, et al., Primary Cilia are Required for Cell-Type Determination and Angiogenesis in Pituitary Development. Endocrinology. 2024 Jul 1;165(8)

TSS for Flt1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr54537	Chr5:147663136-147663167 (-)	-331 bp
Tssr54536	Chr5:147662812-147662833 (-)	-2 bp
Tssr54535	Chr5:147659447-147659450 (-)	3,372 bp
Tssr54534	Chr5:147624846-147624854 (-)	37,971 bp
Tssr54533	Chr5:147574302-147574313 (-)	88,513 bp
Tssr54532	Chr5:147574270-147574277 (-)	88,547 bp
Tssr54531	Chr5:147574109-147574124 (-)	88,704 bp
Tssr54530	Chr5:147529283-147529284 (-)	133,537 bp
Tssr54529	Chr5:147503580-147503587 (-)	159,237 bp
Tssr54528	Chr5:147503554-147503567 (-)	159,260 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24