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Flt3 Gene Detail
Summary
  • Symbol
    Flt3
  • Name
    FMS-like tyrosine kinase 3
  • Synonyms
    CD135, Flk-2, Flk2, Flt-3, wmfl
  • Feature Type
    protein coding gene
  • IDs
    MGI:95559
    NCBI Gene: 14255
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:147267551-147337299 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 86.88 cM, cytoband G3
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2163 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    3
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95559
 protein coding gene Chr5:147267551-147337299 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030389
 protein coding gene Chr5:152980771-153065789 (-)
A/J MGP_AJ_G0030362
 protein coding gene Chr5:146499898-146571771 (-)
AKR/J MGP_AKRJ_G0030289
 protein coding gene Chr5:151001747-151075956 (-)
BALB/cJ MGP_BALBcJ_G0030371
 protein coding gene Chr5:147714498-147784743 (-)
C3H/HeJ MGP_C3HHeJ_G0030085
 protein coding gene Chr5:151966230-152041670 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030826
 protein coding gene Chr5:158579296-158653527 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028039
 protein coding gene Chr5:140916063-140986075 (-)
CAST/EiJ MGP_CASTEiJ_G0029487
 protein coding gene Chr5:151527845-151609035 (-)
CBA/J MGP_CBAJ_G0030063
 protein coding gene Chr5:165211816-165290041 (-)
DBA/2J MGP_DBA2J_G0030207
 protein coding gene Chr5:146183380-146253416 (-)
FVB/NJ MGP_FVBNJ_G0030161
 protein coding gene Chr5:145385032-145458951 (-)
LP/J MGP_LPJ_G0030294
 protein coding gene Chr5:153679096-153758816 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030197
 protein coding gene Chr5:167465458-167553636 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030856
 protein coding gene Chr5:150910006-150984195 (-)
PWK/PhJ MGP_PWKPhJ_G0029201
 protein coding gene Chr5:145272754-145348986 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029037
 protein coding gene Chr5:148235327-148310228 (-)
WSB/EiJ MGP_WSBEiJ_G0029564
 protein coding gene Chr5:151713744-151790982 (-)



Homology
more
  • Human Ortholog
    FLT3, fms related receptor tyrosine kinase 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FLT3, fms related receptor tyrosine kinase 3
  • Synonyms
    CD135, FLK-2, FLK2, STK1
  • Links
    NCBI Gene ID: 2322
    neXtProt AC: NX_P36888
    UniProt: P36888

  • Chr Location
    13q12.2; chr13:28003274-28100592 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with Flt3 mouse models; 6 with human FLT3 associations

Human Disease Mouse Models
      
IDs
 View 4 models
      
IDs
 View 2 models
      
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    3 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    79 phenotypes from 7 alleles in 8 genetic backgrounds
    21 phenotypes from multigenic genotypes
    135 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice functionally null for this gene display abnormal lymphopoiesis. Homozygous ENU mutant mice are sensitive to infection by mouse cytomegalovirus.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    94
  • GO References
    30
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    954
  • Tissues
    98
  • cDNA Data
    27
  • Literature Summary
    18
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14255 NCBI Gene Model | MGI Sequence Detail 69749 C57BL/6J ±  kb
    transcript NM_010229 RefSeq | MGI Sequence Detail 3664 ZRU/MplStud  
    polypeptide Q00342 UniProt | EBI | MGI Sequence Detail 1000 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 40
      Genomic 2
      cDNA 28
      Primer pair 8
      Other 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-9827, MGD-MRK-9834, MGD-MRK-9837, MGI:3626335
    References
    more
    • Summaries
      All 250
      Developmental Gene Expression 18
      Diseases 3
      Gene Ontology 30
      Phenotypes 135
    • Earliest
      J:1614 Rosnet O, et al., Murine Flt3, a gene encoding a novel tyrosine kinase receptor of the PDGFR/CSF1R family. Oncogene. 1991 Sep;6(9):1641-50
    • Latest
      J:347776 Yu CI, et al., Engraftment of adult hematopoietic stem and progenitor cells in a novel model of humanized mice. iScience. 2024 Mar 15;27(3):109238
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    11/12/2024
    MGI 6.24     		The Jackson Laboratory