Flt4 MGI Mouse Gene Detail - MGI:95561 - FMS-like tyrosine kinase 4

Symbol

Flt4
Name

FMS-like tyrosine kinase 4
Synonyms

Flt-4, VEGFR-3, VEGFR3

Feature Type

protein coding gene
IDs

MGI:95561
NCBI Gene: 14257
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr11:49500506-49543566 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 29.69 cM, cytoband A5-B1
Mapping Data

12 experiments

SNPs within 2kb

1071 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_95561	protein coding gene	Chr11:49500090-49543566 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0018234	protein coding gene	Chr11:48736562-48788357 (+)
A/J	MGP_AJ_G0018202	protein coding gene	Chr11:46860584-46909608 (+)
AKR/J	MGP_AKRJ_G0018172	protein coding gene	Chr11:48371154-48415923 (+)
BALB/cJ	MGP_BALBcJ_G0018172	protein coding gene	Chr11:47166655-47195407 (+)
C3H/HeJ	MGP_C3HHeJ_G0017985	protein coding gene	Chr11:48367409-48411206 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0018623	protein coding gene	Chr11:50167137-50242774 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016275	protein coding gene	Chr11:44479385-44535973 (+)
CAST/EiJ	MGP_CASTEiJ_G0017547	protein coding gene	Chr11:48318009-48375429 (+)
CBA/J	MGP_CBAJ_G0017960	protein coding gene	Chr11:52519630-52580703 (+)
DBA/2J	MGP_DBA2J_G0018067	protein coding gene	Chr11:46681010-46738891 (+)
FVB/NJ	MGP_FVBNJ_G0018061	protein coding gene	Chr11:46312914-46342023 (+)
LP/J	MGP_LPJ_G0018142	protein coding gene	Chr11:49059153-49115642 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018086	protein coding gene	Chr11:54076757-54123614 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018667	protein coding gene	Chr11:48471193-48514061 (+)
PWK/PhJ	MGP_PWKPhJ_G0017325	protein coding gene	Chr11:47065360-47109674 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0017120	protein coding gene	Chr11:48160769-48214916 (+)
WSB/EiJ	MGP_WSBEiJ_G0017600	protein coding gene	Chr11:48107497-48159185 (+)

Human Ortholog

FLT4, fms related receptor tyrosine kinase 4

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

FLT4, fms related receptor tyrosine kinase 4
Synonyms

CHTD7, FLT-4, FLT41, LMPH1A, LMPHM1, PCL, VEGFR-3, VEGFR3
Links

HGNC:3767

NCBI Gene ID: 2324

neXtProt AC: NX_P35916

UniProt: P35916
Chr Location

5q35.3; chr5:180601506-180650298 (-) GRCh38

MGI Vertebrate Homology

Flt4 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: FLT4
Protein SuperFamily

TyrPK_CSF1-R
Gene Tree

Flt4

Diseases

1 with Flt4 mouse models; 1 with human FLT4 associations

Human Disease

Mouse Models

hereditary lymphedema

IDs

View 1 model

hereditary lymphedema IA

IDs

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

1 with disease annotations

References

1 with disease annotations

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Phenotype Summary

30 phenotypes from 6 alleles in 6 genetic backgrounds
11 phenotypes from multigenic genotypes
5 images
112 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

22
Chemically induced (ENU)

1
Chemically induced (other)

1
Endonuclease-mediated

5
Targeted

14
Transgenic

1
Genomic Mutations

1 involving Flt4
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

77 strains or lines available
Comparison Matrix

Gene Expression + Phenotype
Recombinase Activity

Comparison Matrix Gene Expression + Recombinase Activity

Embryos homozygous for a targeted null mutation show growth retardation, vascular abnormalities, severe anemia and die from cardiovascular failure at embryonic day 9.5. Heterozygotes for another mutation show abdominal chylous ascites, abnormal lymphaticvessels, and lymphedema.

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All GO Annotations

104
GO References

22

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1044
Tissues

154
cDNA Data

21
Literature Summary

182

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA FLT4

Xenbase flt4

ZFIN flt4

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All Sequences

34
RefSeq

2
UniProt

2
CCDS

CCDS24618.1

Ensembl

ENSMUSG00000020357 (Evidence)
NCBI Gene

14257

			Length	Strain/Species	Flank
genomic	14257	NCBI Gene Model \| MGI Sequence Detail	43061	C57BL/6J	± kb
transcript	NM_008029	RefSeq \| MGI Sequence Detail	5853	ZRU/MplStud
polypeptide	P35917	UniProt \| EBI \| MGI Sequence Detail	1363	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000007565 vascular endothelial growth factor receptor 3

(term hierarchy)
EC

2.7.10.1
InterPro Domains

IPR013098 Immunoglobulin I-set

IPR007110 Immunoglobulin-like domain

IPR036179 Immunoglobulin-like domain superfamily

IPR013783 Immunoglobulin-like fold

IPR003599 Immunoglobulin subtype

IPR003598 Immunoglobulin subtype 2

IPR017441 Protein kinase, ATP binding site

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR050122 Receptor Tyrosine Kinase

IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain

IPR008266 Tyrosine-protein kinase, active site

IPR020635 Tyrosine-protein kinase, catalytic domain

IPR001824 Tyrosine-protein kinase, receptor class III, conserved site

IPR041348 VEGFR-2, transmembrane domain
GlyGen

P35917 14 sites, 4 N-linked glycans (4 sites)

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All nucleic 35

Genomic 1

cDNA 24

Primer pair 8

Other 2

Microarray probesets 5

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MGD-MRK-1984, MGD-MRK-9835, MGD-MRK-9839, MGI:2144119, MGI:88402

Summaries

All 342

Developmental Gene Expression 182

Diseases 1

Gene Ontology 22

Phenotypes 112
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:354188 Vallecillo-Garcia P, et al., Mesenchymal Osr1+ cells regulate embryonic lymphatic vessel formation. Development. 2024 Sep 1;151(17):dev202747

TSS for Flt4:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr101188	Chr11:49500524-49500555 (+)	34 bp
Tssr101189	Chr11:49542601-49542605 (+)	42,097 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24