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Fshr Gene Detail
Summary
  • Symbol
    Fshr
  • Name
    follicle stimulating hormone receptor
  • Synonyms
    follicle-stimulating hormone receptor, Follitropin receptor, FSH-R
  • Feature Type
    protein coding gene
  • IDs
    MGI:95583
    NCBI Gene: 14309
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:89292380-89508103 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 58.76 cM, cytoband E5
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    7081 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95583
 protein coding gene Chr17:89292380-89508103 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024114
 protein coding gene Chr17:92503961-92730974 (-)
A/J MGP_AJ_G0024074
 protein coding gene Chr17:89510660-89738147 (-)
AKR/J MGP_AKRJ_G0024043
 protein coding gene Chr17:91008857-91226846 (-)
BALB/cJ MGP_BALBcJ_G0024075
 protein coding gene Chr17:89334558-89550567 (-)
C3H/HeJ MGP_C3HHeJ_G0023840
 protein coding gene Chr17:91913574-92131326 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024520
 protein coding gene Chr17:95730831-95957732 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021958
 protein coding gene Chr17:84561916-84763428 (-)
CAST/EiJ MGP_CASTEiJ_G0023319
 protein coding gene Chr17:92781944-92999897 (-)
CBA/J MGP_CBAJ_G0023813
 protein coding gene Chr17:99746990-99977967 (-)
DBA/2J MGP_DBA2J_G0023942
 protein coding gene Chr17:87892679-88105200 (-)
FVB/NJ MGP_FVBNJ_G0023908
 protein coding gene Chr17:87439105-87651824 (-)
LP/J MGP_LPJ_G0024026
 protein coding gene Chr17:93286106-93509070 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023936
 protein coding gene Chr17:99510923-99740202 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024565
 protein coding gene Chr17:91560462-91787735 (-)
PWK/PhJ MGP_PWKPhJ_G0023064
 protein coding gene Chr17:87591748-87807459 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022875
 protein coding gene Chr17:88297349-88494643 (-)
WSB/EiJ MGP_WSBEiJ_G0023385
 protein coding gene Chr17:92426183-92640966 (-)



Homology
more
  • Human Ortholog
    FSHR, follicle stimulating hormone receptor
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FSHR, follicle stimulating hormone receptor
  • Synonyms
    FSHR1, FSHRO, LGR1, ODG1
  • Links
    NCBI Gene ID: 2492
    neXtProt AC: NX_P23945
    UniProt: P23945

  • Chr Location
    2p16.3; chr2:48962157-49154527 (-)  GRCh38
Human Diseases
more
  • Diseases
    3 with human FSHR associations

Human Disease Mouse Models
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    160 phenotypes from 8 alleles in 7 genetic backgrounds
    2 images
    53 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mutant females are sterile with small ovaries, blocked follicular development, atrophic uterus and imperforate vagina. Mutant males are fertile despite reduction in testis weight, oligozoospermia and reduced testosterone levels.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    68
  • GO References
    29
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    732
  • Tissues
    13
  • cDNA Data
    5
  • Literature Summary
    15
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14309 NCBI Gene Model | MGI Sequence Detail 215724 C57BL/6J ±  kb
    transcript NM_013523 RefSeq | MGI Sequence Detail 2360 C57BL/6  
    polypeptide P35378 UniProt | EBI | MGI Sequence Detail 692 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 17
      Genomic 7
      cDNA 5
      Primer pair 5

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-9876
    References
    more
    • Summaries
      All 115
      Developmental Gene Expression 15
      Gene Ontology 29
      Phenotypes 53
    • Earliest
      J:2795 Huhtaniemi IT, et al., The murine luteinizing hormone and follicle-stimulating hormone receptor genes: transcription initiation sites, putative promoter sequences and promoter activity. Mol Cell Endocrinol. 1992 Oct;88(1-3):55-66
    • Latest
      J:353442 Luo X, et al., Casein kinase 1alpha mediates estradiol secretion via CYP19A1 expression in mouse ovarian granulosa cells. BMC Biol. 2024 Aug 26;22(1):176
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    11/12/2024
    MGI 6.24     		The Jackson Laboratory