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Fst Gene Detail
Summary
  • Symbol
    Fst
  • Name
    follistatin
  • Feature Type
    protein coding gene
  • IDs
    MGI:95586
    NCBI Gene: 14313
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:114588826-114595487 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 64.15 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    172 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95586
 protein coding gene Chr13:114588798-114595522 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020956
 protein coding gene Chr13:117161830-117168288 (-)
A/J MGP_AJ_G0020906
 protein coding gene Chr13:112461147-112467611 (-)
AKR/J MGP_AKRJ_G0020881
 protein coding gene Chr13:115810970-115817430 (-)
BALB/cJ MGP_BALBcJ_G0020906
 protein coding gene Chr13:113141341-113147795 (-)
C3H/HeJ MGP_C3HHeJ_G0020695
 protein coding gene Chr13:115622124-115630103 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021342
 protein coding gene Chr13:120588326-120594778 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018911
 protein coding gene Chr13:107691593-107698128 (-)
CAST/EiJ MGP_CASTEiJ_G0020214
 protein coding gene Chr13:115293869-115300303 (-)
CBA/J MGP_CBAJ_G0020657
 protein coding gene Chr13:125199225-125206821 (-)
DBA/2J MGP_DBA2J_G0020780
 protein coding gene Chr13:112131758-112138206 (-)
FVB/NJ MGP_FVBNJ_G0020764
 protein coding gene Chr13:110826059-110832521 (-)
LP/J MGP_LPJ_G0020856
 protein coding gene Chr13:117169819-117176277 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020792
 protein coding gene Chr13:125490063-125497322 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021378
 protein coding gene Chr13:115318473-115325223 (-)
PWK/PhJ MGP_PWKPhJ_G0019967
 protein coding gene Chr13:110897084-110931788 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019789
 protein coding gene Chr13:111630881-111637321 (-)
WSB/EiJ MGP_WSBEiJ_G0020272
 protein coding gene Chr13:115910822-115917262 (-)



Homology
more
  • Human Ortholog
    FST, follistatin
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FST, follistatin
  • Synonyms
    FS
  • Links
    NCBI Gene ID: 10468
    neXtProt AC: NX_P19883
    UniProt: P19883

  • Chr Location
    5q11.2; chr5:53480626-53487134 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Fst mouse models; 1 with human FST associations

Human Disease Mouse Models
      
IDs
 View 2 models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    66 phenotypes from 8 alleles in 6 genetic backgrounds
    18 phenotypes from multigenic genotypes
    1 images
    50 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice show retarded growth, reduced diaphragm and intercostal muscle mass that lead to neonatal respiratory failure, shiny tight skin, defects of the hard palate and thirteenth ribs, and abnormal whiskers and teeth. Some conditional mutations produce female reproductive defects.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    35
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1466
  • Tissues
    329
  • cDNA Data
    32
  • Literature Summary
    139
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000021765 Ensembl Gene Model | MGI Sequence Detail 6662 C57BL/6J ±  kb
    transcript ENSMUST00000022287 Ensembl | MGI Sequence Detail 1851 Not Applicable  
    polypeptide ENSMUSP00000022287 Ensembl | MGI Sequence Detail 344 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 62
      cDNA 36
      Primer pair 16
      Other 10

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-9880
    References
    more
    • Summaries
      All 227
      Developmental Gene Expression 139
      Diseases 1
      Gene Ontology 11
      Phenotypes 50
    • Earliest
      J:16356 Nakamura T, et al., Activin-binding protein from rat ovary is follistatin. Science. 1990 Feb 16;247(4944):836-8
    • Latest
      J:354246 Zhu S, et al., Follistatin controls the number of murine teeth by limiting TGF-beta signaling. iScience. 2024 Sep 20;27(9):110785
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory