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Fyn Gene Detail
Summary
  • Symbol
    Fyn
  • Name
    Fyn proto-oncogene
  • Synonyms
    Src Kinase p59
  • Feature Type
    protein coding gene
  • IDs
    MGI:95602
    NCBI Gene: 14360
  • Alliance
    gene page
  • Transcription Start Sites
    19 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:39245735-39441377 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 20.51 cM
  • Mapping Data
    16 experiments
Strain
Comparison
more
  • SNPs within 2kb
    5933 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    3
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95602
 protein coding gene Chr10:39244851-39441377 (+)
129S1/SvImJ MGP_129S1SvImJ_G0017151
 protein coding gene Chr10:37869971-38078548 (+)
A/J MGP_AJ_G0017128
 protein coding gene Chr10:36863130-37064556 (+)
AKR/J MGP_AKRJ_G0017088
 protein coding gene Chr10:37374716-37577794 (+)
BALB/cJ MGP_BALBcJ_G0017091
 protein coding gene Chr10:36909262-37108406 (+)
C3H/HeJ MGP_C3HHeJ_G0016911
 protein coding gene Chr10:37699348-37902704 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017549
 protein coding gene Chr10:39039603-39242400 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015246
 protein coding gene Chr10:34858834-35053021 (+)
CAST/EiJ MGP_CASTEiJ_G0016490
 protein coding gene Chr10:37850454-38057845 (+)
CBA/J MGP_CBAJ_G0016885
 protein coding gene Chr10:40851261-41059490 (+)
DBA/2J MGP_DBA2J_G0016990
 protein coding gene Chr10:36386954-36584354 (+)
FVB/NJ MGP_FVBNJ_G0016985
 protein coding gene Chr10:35889784-36091168 (+)
LP/J MGP_LPJ_G0017067
 protein coding gene Chr10:37838725-38044174 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0017015
 protein coding gene Chr10:41711277-41913079 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017586
 protein coding gene Chr10:37363007-37565888 (+)
PWK/PhJ MGP_PWKPhJ_G0016271
 protein coding gene Chr10:36222333-36423933 (+)
SPRET/EiJ MGP_SPRETEiJ_G0016055
 protein coding gene Chr10:37144140-37348082 (+)
WSB/EiJ MGP_WSBEiJ_G0016553
 protein coding gene Chr10:37635244-37843519 (+)



Homology
more
  • Human Ortholog
    FYN, FYN proto-oncogene, Src family tyrosine kinase
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FYN, FYN proto-oncogene, Src family tyrosine kinase
  • Synonyms
    p59-FYN, SLK, SYN
  • Links
    NCBI Gene ID: 2534
    neXtProt AC: NX_P06241
    UniProt: P06241

  • Chr Location
    6q21; chr6:111660332-111873452 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with Fyn mouse models; 3 with human FYN associations

Human Disease Mouse Models
      
IDs
 View 1 model
IDs
 View 1 model
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    98 phenotypes from 9 alleles in 13 genetic backgrounds
    46 phenotypes from multigenic genotypes
    258 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Different targeted allele homozygotes show different defects, including seizure susceptibility, anxiety, impaired suckling, myelination, LTP and spatial learning, and defects in immune system, circadian rhythm, testes weight and olfactory bulb formation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    165
  • GO References
    61
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    982
  • Tissues
    215
  • cDNA Data
    25
  • Literature Summary
    43
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14360 NCBI Gene Model | MGI Sequence Detail 195643 C57BL/6J ±  kb
    transcript NM_001122893 RefSeq | MGI Sequence Detail 3549 C57BL/6  
    polypeptide P39688 UniProt | EBI | MGI Sequence Detail 537 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 41
      Genomic 3
      cDNA 30
      Primer pair 5
      Other 3

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-9909, MGI:2143602, MGI:2143864
    References
    more
    • Summaries
      All 472
      Developmental Gene Expression 43
      Diseases 2
      Gene Ontology 61
      Phenotypes 258
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/17/2024
    MGI 6.24     		The Jackson Laboratory