Xrcc6 MGI Mouse Gene Detail - MGI:95606 - X-ray repair complementing defective repair in Chinese hamster cells 6

Symbol

Xrcc6
Name

X-ray repair complementing defective repair in Chinese hamster cells 6
Synonyms

G22p1, Ku70, Ku p70

Feature Type

protein coding gene
IDs

MGI:95606
NCBI Gene: 14375
Alliance

gene page
Transcription Start Sites

21 TSS

Sequence Map

Chr15:81872036-81924286 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 38.33 cM, cytoband E-F
Mapping Data

5 experiments

SNPs within 2kb

1498 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_95606	protein coding gene	Chr15:81868805-81924286 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0022129	protein coding gene	Chr15:82468938-82523117 (+)
A/J	MGP_AJ_G0022090	protein coding gene	Chr15:79552738-79605103 (+)
AKR/J	MGP_AKRJ_G0022065	protein coding gene	Chr15:81751795-81803614 (+)
BALB/cJ	MGP_BALBcJ_G0022095	protein coding gene	Chr15:79598629-79651390 (+)
C3H/HeJ	MGP_C3HHeJ_G0021866	protein coding gene	Chr15:81772236-81827349 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0022538	protein coding gene	Chr15:85704646-85757554 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020067	protein coding gene	Chr15:75993345-76046489 (+)
CAST/EiJ	MGP_CASTEiJ_G0021386	protein coding gene	Chr15:82561223-82618920 (+)
CBA/J	MGP_CBAJ_G0021831	protein coding gene	Chr15:88377297-88431517 (+)
DBA/2J	MGP_DBA2J_G0021960	protein coding gene	Chr15:79025380-79077420 (+)
FVB/NJ	MGP_FVBNJ_G0021937	protein coding gene	Chr15:78072593-78127384 (+)
LP/J	MGP_LPJ_G0022028	protein coding gene	Chr15:82609199-82666937 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021958	protein coding gene	Chr15:93302006-93355312 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022553	protein coding gene	Chr15:81850164-81908796 (+)
PWK/PhJ	MGP_PWKPhJ_G0021128	protein coding gene	Chr15:79074913-79129669 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0020967	protein coding gene	Chr15:81645128-81705013 (+)
WSB/EiJ	MGP_WSBEiJ_G0021438	protein coding gene	Chr15:82281359-82332868 (+)

Human Ortholog

XRCC6, X-ray repair cross complementing 6

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

XRCC6, X-ray repair cross complementing 6
Synonyms

CTC75, CTCBF, G22P1, KU70, ML8, TLAA
Links

HGNC:4055

NCBI Gene ID: 2547

neXtProt AC: NX_P12956

UniProt: P12956
Chr Location

22q13.2; chr22:41621163-41664048 (+) GRCh38

MGI Vertebrate Homology

Xrcc6 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: XRCC6
Protein SuperFamily

Ku70
Gene Tree

Xrcc6

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References

1 with disease annotations

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Phenotype Summary

38 phenotypes from 3 alleles in 4 genetic backgrounds
1 phenotype from multigenic genotypes
78 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

52
Chemically induced (ENU)

1
Chemically induced (other)

1
Endonuclease-mediated

9
Gene trapped

32
Radiation induced

2
Targeted

7
Genomic Mutations

3 involving Xrcc6
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

63 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit neuron apoptosis, decreased body size, abnormal B and T cell morphology, increased incidence of tumorigenesis, and increased cellular sensitivity to irradiation.

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All GO Annotations

72
GO References

21

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

815
Tissues

28
cDNA Data

97
Literature Summary

6

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase xrcc6

ZFIN xrcc6

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All Sequences

74
RefSeq

13
UniProt

6
CCDS

CCDS37153.1

Ensembl

ENSMUSG00000022471 (Evidence)
NCBI Gene

14375

			Length	Strain/Species	Flank
genomic	ENSMUSG00000022471	Ensembl Gene Model \| MGI Sequence Detail	52251	C57BL/6J	± kb
transcript	ENSMUST00000069530	Ensembl \| MGI Sequence Detail	2114	Not Applicable
polypeptide	ENSMUSP00000068559	Ensembl \| MGI Sequence Detail	608	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000017509 X-ray repair cross-complementing protein 6

(term hierarchy)
EC

3.6.4.-, 4.2.99.-
InterPro Domains

IPR006165 Ku70

IPR027388 Ku70, bridge and pillars domain superfamily

IPR047087 Ku70, core domain

IPR006164 Ku70/Ku80 beta-barrel domain

IPR005160 Ku70/Ku80 C-terminal arm

IPR005161 Ku70/Ku80, N-terminal alpha/beta

IPR003034 SAP domain

IPR036361 SAP domain superfamily

IPR016194 SPOC-like, C-terminal domain superfamily

IPR036465 von Willebrand factor A-like domain superfamily

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All nucleic 102

Genomic 2

cDNA 99

Primer pair 1

Microarray probesets 3

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MGD-MRK-9914

Summaries

All 153

Developmental Gene Expression 6

Diseases 1

Gene Ontology 21

Phenotypes 78
Earliest

J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
Latest

J:344560 Pandey A, et al., Ku70 senses cytosolic DNA and assembles a tumor-suppressive signalosome. Sci Adv. 2024 Jan 26;10(4):eadh3409

TSS for Xrcc6:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr132322	Chr15:81872036-81872049 (+)	7 bp
Tssr132323	Chr15:81872484-81872487 (+)	450 bp
Tssr132324	Chr15:81900579-81900620 (+)	28,564 bp
Tssr132325	Chr15:81900621-81900660 (+)	28,605 bp
Tssr132326	Chr15:81901276-81901288 (+)	29,246 bp
Tssr132327	Chr15:81901309-81901316 (+)	29,277 bp
Tssr132328	Chr15:81902006-81902009 (+)	29,972 bp
Tssr132329	Chr15:81906894-81906927 (+)	34,875 bp
Tssr132330	Chr15:81906941-81906958 (+)	34,914 bp
Tssr132331	Chr15:81906977-81907002 (+)	34,954 bp
Tssr132332	Chr15:81907027-81907041 (+)	34,998 bp
Tssr132333	Chr15:81907058-81907073 (+)	35,030 bp
Tssr132334	Chr15:81907124-81907135 (+)	35,094 bp
Tssr132335	Chr15:81907155-81907166 (+)	35,125 bp
Tssr132336	Chr15:81912226-81912247 (+)	40,201 bp
Tssr132337	Chr15:81912255-81912276 (+)	40,230 bp
Tssr132338	Chr15:81912290-81912295 (+)	40,257 bp
Tssr132339	Chr15:81912312-81912334 (+)	40,287 bp
Tssr132340	Chr15:81912709-81912713 (+)	40,675 bp
Tssr132341	Chr15:81913404-81913414 (+)	41,373 bp
Tssr132342	Chr15:81920650-81920673 (+)	48,626 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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