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G6pc1 Gene Detail
Summary
  • Symbol
    G6pc1
  • Name
    glucose-6-phosphatase catalytic subunit 1
  • Synonyms
    G6Pase, G6pc, G6pt, Glc-6-Pase, Glc-6-Pase-alpha
  • Feature Type
    protein coding gene
  • IDs
    MGI:95607
    NCBI Gene: 14377
  • Alliance
    gene page
  • Transcription Start Sites
    15 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:101258542-101268729 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 64.83 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    392 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95607
 protein coding gene Chr11:101258387-101268729 (+)
129S1/SvImJ MGP_129S1SvImJ_G0019197
 protein coding gene Chr11:104219021-104229536 (+)
A/J MGP_AJ_G0019165
 protein coding gene Chr11:99838461-99848798 (+)
AKR/J MGP_AKRJ_G0019134
 protein coding gene Chr11:102938144-102950776 (+)
BALB/cJ MGP_BALBcJ_G0019139
 protein coding gene Chr11:100323659-100334466 (+)
C3H/HeJ MGP_C3HHeJ_G0018948
 protein coding gene Chr11:103114683-103125003 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019588
 protein coding gene Chr11:107489085-107501555 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017214
 protein coding gene Chr11:97247552-97258174 (+)
CAST/EiJ MGP_CASTEiJ_G0018502
 protein coding gene Chr11:104104862-104115408 (+)
CBA/J MGP_CBAJ_G0018917
 protein coding gene Chr11:111917527-111927862 (+)
DBA/2J MGP_DBA2J_G0019029
 protein coding gene Chr11:99364662-99374984 (+)
FVB/NJ MGP_FVBNJ_G0019019
 protein coding gene Chr11:98910204-98920544 (+)
LP/J MGP_LPJ_G0019098
 protein coding gene Chr11:104765674-104775996 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019050
 protein coding gene Chr11:111479386-111491813 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019626
 protein coding gene Chr11:103270592-103281720 (+)
PWK/PhJ MGP_PWKPhJ_G0018265
 protein coding gene Chr11:100421752-100432563 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018057
 protein coding gene Chr11:103002976-103013381 (+)
WSB/EiJ MGP_WSBEiJ_G0018551
 protein coding gene Chr11:103265468-103276142 (+)



Homology
more
  • Human Ortholog
    G6PC1, glucose-6-phosphatase catalytic subunit 1
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    G6PC1, glucose-6-phosphatase catalytic subunit 1
  • Synonyms
    G6Pase, G6PC, G6PT, GSD1, GSD1a
  • Links
    NCBI Gene ID: 2538
    neXtProt AC: NX_P35575
    UniProt: P35575

  • Chr Location
    17q21.31; chr17:42900797-42914438 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with G6pc1 mouse models; 2 with human G6PC1 associations

Human Disease Mouse Models
      
IDs
 View 5 models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    4 with disease annotations
  • References
    5 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    47 phenotypes from 4 alleles in 5 genetic backgrounds
    1 images
    54 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene tend to die within a couple of weeks of weaning. Blood chemistry and glucose metabolism are abnormal as is glycogen storage.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    33
  • GO References
    15
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    899
  • Tissues
    121
  • cDNA Data
    47
  • Literature Summary
    38
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14377 NCBI Gene Model | MGI Sequence Detail 10188 C57BL/6J ±  kb
    transcript NM_008061 RefSeq | MGI Sequence Detail 2274 C57BL/6  
    polypeptide P35576 UniProt | EBI | MGI Sequence Detail 357 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 62
      Genomic 1
      cDNA 48
      Primer pair 12
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-9916, MGI:2144495, MGI:7484523
    References
    more
    • Summaries
      All 145
      Developmental Gene Expression 38
      Diseases 5
      Gene Ontology 15
      Phenotypes 54
    • Earliest
      J:12701 Hanigan MH, et al., Induction of three histochemically distinct populations of hepatic foci in C57BL/6J mice. Carcinogenesis. 1993 May;14(5):1035-40
    • Latest
      J:348105 Chen H, et al., Pre-eclamptic foetal programming predisposes offspring to hepatic steatosis via DNA methylation. Biochim Biophys Acta Mol Basis Dis. 2024 Apr 20;1870(5):167189
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory