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Gad2 Gene Detail
Summary
  • Symbol
    Gad2
  • Name
    glutamic acid decarboxylase 2
  • Synonyms
    6330404F12Rik, Gad-2, GAD(65), GAD65
  • Feature Type
    protein coding gene
  • IDs
    MGI:95634
    NCBI Gene: 14417
  • Alliance
    gene page
  • Transcription Start Sites
    15 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:22512262-22583889 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 15.15 cM, cytoband A-B
  • Mapping Data
    13 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2155 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95634
 protein coding gene Chr2:22512217-22583889 (+)
129S1/SvImJ MGP_129S1SvImJ_G0025391
 protein coding gene Chr2:20333510-20409496 (+)
A/J MGP_AJ_G0025369
 protein coding gene Chr2:19510378-19581822 (+)
AKR/J MGP_AKRJ_G0025338
 protein coding gene Chr2:20210446-20287479 (+)
BALB/cJ MGP_BALBcJ_G0025364
 protein coding gene Chr2:19625940-19696166 (+)
C3H/HeJ MGP_C3HHeJ_G0025125
 protein coding gene Chr2:20120495-20193604 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025808
 protein coding gene Chr2:20930349-21005596 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023222
 protein coding gene Chr2:18614120-18684356 (+)
CAST/EiJ MGP_CASTEiJ_G0024588
 protein coding gene Chr2:20039467-20111231 (+)
CBA/J MGP_CBAJ_G0025103
 protein coding gene Chr2:21723285-21801658 (+)
DBA/2J MGP_DBA2J_G0025236
 protein coding gene Chr2:19412841-19485917 (+)
FVB/NJ MGP_FVBNJ_G0025198
 protein coding gene Chr2:19201212-19275673 (+)
LP/J MGP_LPJ_G0025322
 protein coding gene Chr2:20279516-20352749 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0025229
 protein coding gene Chr2:21776386-21854954 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025867
 protein coding gene Chr2:20088814-20160349 (+)
PWK/PhJ MGP_PWKPhJ_G0024337
 protein coding gene Chr2:19225122-19295856 (+)
SPRET/EiJ MGP_SPRETEiJ_G0024137
 protein coding gene Chr2:20221013-20291413 (+)
WSB/EiJ MGP_WSBEiJ_G0024658
 protein coding gene Chr2:20242435-20317557 (+)



Homology
more
  • Human Ortholog
    GAD2, glutamate decarboxylase 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GAD2, glutamate decarboxylase 2
  • Synonyms
    GAD65
  • Links
    NCBI Gene ID: 2572
    neXtProt AC: NX_Q05329
    UniProt: Q05329

  • Chr Location
    10p12.1; chr10:26216372-26304558 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with Gad2 mouse models; 7 with human GAD2 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
 View 1 model
      
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    27 phenotypes from 7 alleles in 8 genetic backgrounds
    20 phenotypes from multigenic genotypes
    454 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit spontaneous (frequently fatal) seizures, increased anxiety-like behavior, and reduced intermale aggression. Heterozygotes show reduced aggressiveness.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    41
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1597
  • Tissues
    310
  • cDNA Data
    17
  • Literature Summary
    179
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14417 NCBI Gene Model | MGI Sequence Detail 71628 C57BL/6J ±  kb
    transcript NM_008078 RefSeq | MGI Sequence Detail 5625 ZRU/MplStud  
    polypeptide P48320 UniProt | EBI | MGI Sequence Detail 585 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 38
      Genomic 1
      cDNA 23
      Primer pair 10
      Other 4

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGD-MRK-9955, MGD-MRK-9959, MGI:1918008
    References
    more
    • Summaries
      All 701
      Developmental Gene Expression 179
      Diseases 2
      Gene Ontology 9
      Phenotypes 454
    • Earliest
      J:16802 Maxson SC, et al., Electroencephalographic correlates of the audiogenic seizure response of inbred mice. Physiol Behav. 1976 May;16(5):623-9
    • Latest
      J:355023 Heiss JE, et al., Distinct lateral hypothalamic CaMKIIalpha neuronal populations regulate wakefulness and locomotor activity. Proc Natl Acad Sci U S A. 2024 Apr 16;121(16):e2316150121
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory