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Galt Gene Detail
Summary
  • Symbol
    Galt
  • Name
    galactose-1-phosphate uridyl transferase
  • Feature Type
    protein coding gene
  • IDs
    MGI:95638
    NCBI Gene: 14430
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:41755228-41758695 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 22.07 cM
  • Mapping Data
    10 experiments
Strain
Comparison
more
  • SNPs within 2kb
    139 from dbSNP Build 142
  • Strain Annotations
    17
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95638
 protein coding gene Chr4:41755228-41759243 (+)
129S1/SvImJ MGP_129S1SvImJ_G0028172
 protein coding gene Chr4:39722112-39725579 (+)
A/J MGP_AJ_G0028130
 protein coding gene Chr4:38211681-38215148 (+)
AKR/J MGP_AKRJ_G0028093
 protein coding gene Chr4:39203789-39207269 (+)
BALB/cJ MGP_BALBcJ_G0028143
 protein coding gene Chr4:38554354-38557821 (+)
C3H/HeJ MGP_C3HHeJ_G0027881
 protein coding gene Chr4:39793476-39796943 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028584
 protein coding gene Chr4:41217889-41221356 (+)
CAROLI/EiJ no annotation
CAST/EiJ MGP_CASTEiJ_G0027326
 protein coding gene Chr4:39438298-39441765 (+)
CBA/J MGP_CBAJ_G0027843
 protein coding gene Chr4:42589969-42593436 (+)
DBA/2J MGP_DBA2J_G0027987
 protein coding gene Chr4:38139651-38143118 (+)
FVB/NJ MGP_FVBNJ_G0027954
 protein coding gene Chr4:37459998-37463465 (+)
LP/J MGP_LPJ_G0028095
 protein coding gene Chr4:39812865-39816332 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027986
 protein coding gene Chr4:45902049-45905529 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028642
 protein coding gene Chr4:39314472-39317952 (+)
PWK/PhJ MGP_PWKPhJ_G0027045
 protein coding gene Chr4:38180726-38184325 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026872
 protein coding gene Chr4:39045915-39049396 (+)
WSB/EiJ MGP_WSBEiJ_G0027402
 protein coding gene Chr4:39298142-39301609 (+)



Homology
more
  • Human Ortholog
    GALT, galactose-1-phosphate uridylyltransferase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GALT, galactose-1-phosphate uridylyltransferase
  • Links
    NCBI Gene ID: 2592
    neXtProt AC: NX_P07902
    UniProt: P07902

  • Chr Location
    9p13.3; chr9:34638133-34651035 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Galt mouse models; 1 with human GALT associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 2 alleles in 2 genetic backgrounds
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation exhibit abnormal galactose metabolism, but lack symptoms of acute toxicity seen in humans with galactosemia.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    22
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    827
  • Tissues
    112
  • cDNA Data
    9
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000036073 Ensembl Gene Model | MGI Sequence Detail 3468 C57BL/6J ±  kb
    transcript ENSMUST00000084695 Ensembl | MGI Sequence Detail 1595 Not Applicable  
    polypeptide ENSMUSP00000081745 Ensembl | MGI Sequence Detail 360 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      9 Sequences
    • Protein Ontology
      PR:000007834 galactose-1-phosphate uridylyltransferase
      (term hierarchy)
    • EC
      2.7.7.12
    • InterPro Domains
      IPR001937 Galactose-1-phosphate uridyl transferase, class I
      IPR019779 Galactose-1-phosphate uridyl transferase, class I His-active site
      IPR005850 Galactose-1-phosphate uridyl transferase, C-terminal
      IPR005849 Galactose-1-phosphate uridyl transferase, N-terminal
      IPR036265 HIT-like superfamily
    Molecular
    Reagents
    less
    • All nucleic 14
      Genomic 3
      cDNA 10
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-9964, MGI:2147374
    References
    more
    • Summaries
      All 57
      Developmental Gene Expression 5
      Diseases 1
      Gene Ontology 8
      Phenotypes 17
    • Earliest
      J:6674 Stallings RL, et al., Confirmational, provisional, and/or regional assignment of 15 enzyme loci onto Chinese hamster autosomes 1, 2, and 7. Somatic Cell Genet. 1981 Nov;7(6):683-98
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory