Gap43 MGI Mouse Gene Detail - MGI:95639 - growth associated protein 43

Symbol

Gap43
Name

growth associated protein 43
Synonyms

B-50, Basp2, GAP-43, neuromodulin

Feature Type

protein coding gene
IDs

MGI:95639
NCBI Gene: 14432
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr16:42068915-42161014 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 16, 28.37 cM
Mapping Data

34 experiments

SNPs within 2kb

2468 from dbSNP Build 142
Strain Annotations

18
RFLP

8

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_95639	protein coding gene	Chr16:42068805-42161014 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0022826	protein coding gene	Chr16:40924108-41021468 (-)
A/J	MGP_AJ_G0022791	protein coding gene	Chr16:39018107-39112298 (-)
AKR/J	MGP_AKRJ_G0022763	protein coding gene	Chr16:40345597-40443493 (-)
BALB/cJ	MGP_BALBcJ_G0022792	protein coding gene	Chr16:39029744-39123644 (-)
C3H/HeJ	MGP_C3HHeJ_G0022556	protein coding gene	Chr16:40495842-40599145 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0023239	protein coding gene	Chr16:41864766-41965158 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020754	protein coding gene	Chr16:39183748-39272358 (-)
CAST/EiJ	MGP_CASTEiJ_G0022082	protein coding gene	Chr16:40697873-40797768 (-)
CBA/J	MGP_CBAJ_G0022527	protein coding gene	Chr16:43657295-43761527 (-)
DBA/2J	MGP_DBA2J_G0022659	protein coding gene	Chr16:38787517-38884394 (-)
FVB/NJ	MGP_FVBNJ_G0022634	protein coding gene	Chr16:38772154-38865022 (-)
LP/J	MGP_LPJ_G0022727	protein coding gene	Chr16:40615052-40712679 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022653	protein coding gene	Chr16:42988022-43083871 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0023254	protein coding gene	Chr16:40330898-40429071 (-)
PWK/PhJ	MGP_PWKPhJ_G0021822	protein coding gene	Chr16:39193004-39287777 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0021653	protein coding gene	Chr16:40256241-40361093 (-)
WSB/EiJ	MGP_WSBEiJ_G0022126	protein coding gene	Chr16:40437648-40534387 (-)

Human Ortholog

GAP43, growth associated protein 43

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

GAP43, growth associated protein 43
Synonyms

B-50, GAP-43, PP46
Links

HGNC:4140

NCBI Gene ID: 2596

neXtProt AC: NX_P17677

UniProt: P17677
Chr Location

3q13.31; chr3:115623510-115721490 (+) GRCh38

MGI Vertebrate Homology

Gap43 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: GAP43
Gene Tree

Gap43

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Phenotype Summary

15 phenotypes from 3 alleles in 4 genetic backgrounds
43 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

32
Endonuclease-mediated

1
Gene trapped

20
Targeted

6
Transgenic

5
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

27 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit postnatal lethality, abnormal optic nerve innervation, and decreased body weight.

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All GO Annotations

45
GO References

18

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1541
Tissues

304
cDNA Data

90
Literature Summary

196

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

GEISHA GAP43

Xenbase gap43

ZFIN gap43

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All Sequences

33
RefSeq

2
UniProt

1
CCDS

CCDS28177.1

Ensembl

ENSMUSG00000047261 (Evidence)
NCBI Gene

14432

			Length	Strain/Species	Flank
genomic	14432	NCBI Gene Model \| MGI Sequence Detail	92100	C57BL/6J	± kb
transcript	NM_008083	RefSeq \| MGI Sequence Detail	1316	Not Specified
polypeptide	P06837	UniProt \| EBI \| MGI Sequence Detail	227	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000007839 neuromodulin

(term hierarchy)
PDB

4E53
InterPro Domains

IPR000048 IQ motif, EF-hand binding site

IPR001422 Neuromodulin (GAP-43)

IPR017454 Neuromodulin (GAP-43), C-terminal

IPR018947 Neuromodulin gap junction N-terminal

IPR018243 Neuromodulin, palmitoylation site

IPR033137 Neuromodulin, phosphorylation site
GlyGen

P06837 2 sites, 1 O-linked glycan (2 sites)

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All nucleic 105

cDNA 95

Primer pair 3

Other 7

Microarray probesets 3

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MGD-MRK-9966

Summaries

All 320

Developmental Gene Expression 196

Gene Ontology 18

Phenotypes 43
Earliest

J:8666 Reeves RH, et al., Genetic mapping of Prm-1, Igl-1, Smst, Mtv-6, Sod-1, and Ets-2 and localization of the Down syndrome region on mouse chromosome 16. Cytogenet Cell Genet. 1987;44(2-3):76-81
Latest

J:357284 Lo Giudice Q, et al., Developmental emergence of first- and higher-order thalamic neuron molecular identities. Development. 2024 Sep 15;151(18)

TSS for Gap43:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr141135	Chr16:42161059-42161086 (-)	-59 bp
Tssr141134	Chr16:42160958-42160993 (-)	38 bp
Tssr141133	Chr16:42160947-42160954 (-)	63 bp
Tssr141132	Chr16:42160867-42160927 (-)	117 bp
Tssr141131	Chr16:42112501-42112516 (-)	48,505 bp
Tssr141130	Chr16:42111335-42111340 (-)	49,676 bp
Tssr141129	Chr16:42069422-42069435 (-)	91,585 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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