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Gapdh Gene Detail
Summary
  • Symbol
    Gapdh
  • Name
    glyceraldehyde-3-phosphate dehydrogenase
  • Synonyms
    Gapd
  • Feature Type
    protein coding gene
  • IDs
    MGI:95640
    NCBI Gene: 14433
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:125138812-125143450 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 59.32 cM, cytoband C
  • Mapping Data
    15 experiments
Strain
Comparison
more
  • SNPs within 2kb
    169 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95640
 protein coding gene Chr6:125138678-125143450 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031288
 protein coding gene Chr6:128493116-128498571 (-)
A/J MGP_AJ_G0031258
 protein coding gene Chr6:123646354-123651423 (-)
AKR/J MGP_AKRJ_G0031186
 protein coding gene Chr6:127022456-127026300 (-)
BALB/cJ MGP_BALBcJ_G0031266
 protein coding gene Chr6:123243458-123248820 (-)
C3H/HeJ MGP_C3HHeJ_G0030989
 protein coding gene Chr6:127094521-127099833 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031722
 protein coding gene Chr6:131871284-131878724 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028871
 protein coding gene Chr6:120854027-120856276 (-)
CAST/EiJ MGP_CASTEiJ_G0030370
 protein coding gene Chr6:127297255-127300971 (-)
CBA/J MGP_CBAJ_G0030950
 protein coding gene Chr6:136933331-136938260 (-)
DBA/2J MGP_DBA2J_G0031106
 protein coding gene Chr6:122577359-122582080 (-)
FVB/NJ MGP_FVBNJ_G0031056
 protein coding gene Chr6:121493301-121495617 (-)
LP/J MGP_LPJ_G0031186
 protein coding gene Chr6:128658162-128662628 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0031094
 protein coding gene Chr6:140965165-140968959 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031757
 protein coding gene Chr6:126923934-126928690 (-)
PWK/PhJ MGP_PWKPhJ_G0030085
 protein coding gene Chr6:120820491-120824655 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029914
 protein coding gene Chr6:124999107-125005018 (-)
WSB/EiJ MGP_WSBEiJ_G0030455
 protein coding gene Chr6:127294415-127298214 (-)



Homology
more
  • Human Ortholog
    GAPDH, glyceraldehyde-3-phosphate dehydrogenase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GAPDH, glyceraldehyde-3-phosphate dehydrogenase
  • Synonyms
    G3PD, GAPD, HEL-S-162eP
  • Links
    NCBI Gene ID: 2597
    neXtProt AC: NX_P04406
    UniProt: P04406

  • Chr Location
    12p13.31; chr12:6534512-6538374 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human GAPDH associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    19 phenotypes from 10 alleles in 11 genetic backgrounds
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mutant heterozygotes show reduced enzyme levels. The currently known mutant allels are homozygous lethal.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    88
  • GO References
    38
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1016
  • Tissues
    210
  • cDNA Data
    30
  • Literature Summary
    53
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14433 NCBI Gene Model | MGI Sequence Detail 4639 C57BL/6J ±  kb
    transcript NM_001411845 RefSeq | MGI Sequence Detail 1633 ZRU/MplStud  
    polypeptide P16858 UniProt | EBI | MGI Sequence Detail 333 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      8 Sequences
    • Protein Ontology
      PR:000007840 glyceraldehyde-3-phosphate dehydrogenase
      (term hierarchy)
    • PDB
      6LGJ, 6LGK, 6LGM
    • EC
      1.2.1.12, 2.6.99.-
    • InterPro Domains
      IPR020830 Glyceraldehyde 3-phosphate dehydrogenase, active site
      IPR020829 Glyceraldehyde 3-phosphate dehydrogenase, catalytic domain
      IPR020828 Glyceraldehyde 3-phosphate dehydrogenase, NAD(P) binding domain
      IPR006424 Glyceraldehyde-3-phosphate dehydrogenase, type I
      IPR020831 Glyceraldehyde/Erythrose phosphate dehydrogenase family
      IPR036291 NAD(P)-binding domain superfamily
    • GlyGen
      P16858 3 sites, 1 O-linked glycan (3 sites)
    Molecular
    Reagents
    less
    • All nucleic 47
      cDNA 33
      Primer pair 12
      Other 2

      Microarray probesets 29
    Other
    Accession IDs
    less
    MGD-MRK-9967, MGI:3579984
    References
    more
    • Summaries
      All 204
      Developmental Gene Expression 53
      Gene Ontology 38
      Phenotypes 16
    • Earliest
      J:2409 Crew FAE, et al., The character of "hairless" in the mouse. J Genet. 1931;25(1):17-24
    • Latest
      J:346910 Ayyangar U, et al., Metabolic rewiring of macrophages by epidermal-derived lactate promotes sterile inflammation in the murine skin. EMBO J. 2024 Apr;43(7):1113-1134
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    12/10/2024
    MGI 6.24     		The Jackson Laboratory