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Gart Gene Detail
Summary
  • Symbol
    Gart
  • Name
    phosphoribosylglycinamide formyltransferase
  • Synonyms
    Gaps, Prgs
  • Feature Type
    protein coding gene
  • IDs
    MGI:95654
    NCBI Gene: 14450
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:91418074-91443840 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 53.18 cM, cytoband C3-C4
  • Mapping Data
    13 experiments
Strain
Comparison
more
  • SNPs within 2kb
    839 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    4
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95654
 protein coding gene Chr16:91418074-91444505 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023045
 protein coding gene Chr16:92649228-92674730 (-)
A/J MGP_AJ_G0023013
 protein coding gene Chr16:88314175-88340278 (-)
AKR/J MGP_AKRJ_G0022983
 protein coding gene Chr16:90984640-91010038 (-)
BALB/cJ MGP_BALBcJ_G0023015
 protein coding gene Chr16:88841184-88867490 (-)
C3H/HeJ MGP_C3HHeJ_G0022776
 protein coding gene Chr16:91558702-91585083 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023462
 protein coding gene Chr16:95639415-95668166 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020964
 protein coding gene Chr16:86010954-86037636 (-)
CAST/EiJ MGP_CASTEiJ_G0022295
 protein coding gene Chr16:92120819-92147766 (-)
CBA/J MGP_CBAJ_G0022745
 protein coding gene Chr16:99723798-99757123 (-)
DBA/2J MGP_DBA2J_G0022879
 protein coding gene Chr16:88218411-88244330 (-)
FVB/NJ MGP_FVBNJ_G0022853
 protein coding gene Chr16:87343676-87369209 (-)
LP/J MGP_LPJ_G0022949
 protein coding gene Chr16:92349531-92374830 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022874
 protein coding gene Chr16:104269710-104298984 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023480
 protein coding gene Chr16:91504735-91530123 (-)
PWK/PhJ MGP_PWKPhJ_G0022040
 protein coding gene Chr16:88395793-88422656 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021870
 protein coding gene Chr16:91063813-91090740 (-)
WSB/EiJ MGP_WSBEiJ_G0022347
 protein coding gene Chr16:91744194-91774127 (-)



Homology
more
  • Human Ortholog
    GART, phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GART, phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase
  • Synonyms
    AIRS, GARS, GARTF, PAIS, PGFT, PRGS
  • Links
    NCBI Gene ID: 2618
    neXtProt AC: NX_P22102
    UniProt: P22102

  • Chr Location
    21q22.11; chr21:33503931-33543491 (-)  GRCh38
Human Diseases
less
  • References
    4 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    85 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    33
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    879
  • Tissues
    146
  • cDNA Data
    253
  • Literature Summary
    5
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000022962 Ensembl Gene Model | MGI Sequence Detail 25767 C57BL/6J ±  kb
transcript ENSMUST00000023684 Ensembl | MGI Sequence Detail 3518 Not Applicable  
polypeptide ENSMUSP00000023684 Ensembl | MGI Sequence Detail 1010 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    8 Sequences
  • Protein Ontology
    PR:000007847 trifunctional purine biosynthetic protein adenosine-3
    (term hierarchy)
  • EC
    2.1.2.2, 6.3.3.1, 6.3.4.13
  • InterPro Domains
    IPR011761 ATP-grasp fold
    IPR013815 ATP-grasp fold, subdomain 1
    IPR002376 Formyl transferase, N-terminal
    IPR036477 Formyl transferase, N-terminal domain superfamily
    IPR004733 Phosphoribosylformylglycinamidine cyclo-ligase
    IPR004607 Phosphoribosylglycinamide formyltransferase
    IPR001555 Phosphoribosylglycinamide formyltransferase, active site
    IPR000115 Phosphoribosylglycinamide synthetase
    IPR020561 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain
    IPR020560 Phosphoribosylglycinamide synthetase, C-domain
    IPR037123 Phosphoribosylglycinamide synthetase, C-domain superfamily
    IPR020559 Phosphoribosylglycinamide synthetase, conserved site
    IPR020562 Phosphoribosylglycinamide synthetase, N-terminal
    IPR016185 Pre-ATP-grasp domain superfamily
    IPR010918 PurM-like, C-terminal domain
    IPR036676 PurM-like, C-terminal domain superfamily
    IPR016188 PurM-like, N-terminal domain
    IPR036921 PurM-like, N-terminal domain superfamily
    IPR011054 Rudiment single hybrid motif
  • GlyGen
    Q64737 1 site, 1 O-linked glycan (1 site)
Molecular
Reagents
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  • All nucleic 273
    Genomic 12
    cDNA 257
    Primer pair 1
    Other 3

    Microarray probesets 6
Other
Accession IDs
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MGD-MRK-13607, MGD-MRK-9982, MGD-MRK-9984
References
more
  • Summaries
    All 129
    Developmental Gene Expression 5
    Diseases 4
    Gene Ontology 8
    Phenotypes 85
  • Earliest
    J:12144 Cox DR, et al., Chromosomal assignment of mouse PRGS: further evidence for homology between mouse chromosome 16 and human chromosome 21. Am J Hum Genet. 1981;33:145A (Abstr.)
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory