Gas5 MGI Mouse Gene Detail - MGI:95659 - growth arrest specific 5

Symbol

Gas5
Name

growth arrest specific 5
Synonyms

Gas-5, Snhg2

Feature Type

lncRNA gene
IDs

MGI:95659
NCBI Gene: 14455
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr1:160862171-160866109 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 69.75 cM
Mapping Data

1 experiment

SNPs within 2kb

294 from dbSNP Build 142
Strain Annotations

18
PCR

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_95659	lncRNA gene	Chr1:160861992-160866116 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0015120	unclassified non-coding RNA gene	Chr1:166285523-166289640 (+)
A/J	MGP_AJ_G0015094	unclassified non-coding RNA gene	Chr1:159517871-159521985 (+)
AKR/J	MGP_AKRJ_G0015057	unclassified non-coding RNA gene	Chr1:164386196-164390313 (+)
BALB/cJ	MGP_BALBcJ_G0015057	unclassified non-coding RNA gene	Chr1:160059536-160063644 (+)
C3H/HeJ	MGP_C3HHeJ_G0014880	unclassified non-coding RNA gene	Chr1:164587385-164591502 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0015513	unclassified non-coding RNA gene	Chr1:171932009-171936126 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0013259	unclassified non-coding RNA gene	Chr1:151635810-151640057 (+)
CAST/EiJ	MGP_CASTEiJ_G0014434	unclassified non-coding RNA gene	Chr1:164196426-164200543 (+)
CBA/J	MGP_CBAJ_G0014859	unclassified non-coding RNA gene	Chr1:178013871-178017988 (+)
DBA/2J	MGP_DBA2J_G0014952	unclassified non-coding RNA gene	Chr1:158497256-158501364 (+)
FVB/NJ	MGP_FVBNJ_G0014963	unclassified non-coding RNA gene	Chr1:156906392-156910509 (+)
LP/J	MGP_LPJ_G0015034	unclassified non-coding RNA gene	Chr1:167375338-167379455 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0014990	unclassified non-coding RNA gene	Chr1:185587357-185591474 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0015552	unclassified non-coding RNA gene	Chr1:164204900-164209017 (+)
PWK/PhJ	MGP_PWKPhJ_G0014226	unclassified non-coding RNA gene	Chr1:157653285-157657388 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0014014	unclassified non-coding RNA gene	Chr1:163100303-163104435 (+)
WSB/EiJ	MGP_WSBEiJ_G0014537	unclassified non-coding RNA gene	Chr1:164395134-164400127 (+)

Human Ortholog

GAS5, growth arrest specific 5

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

GAS5, growth arrest specific 5
Synonyms

NCRNA00030, SNHG2
Links

HGNC:16355

NCBI Gene ID: 60674
Chr Location

1q25.1; chr1:173858559-173869045 (-) GRCh38

MGI Vertebrate Homology

Gas5 stringent orthology
1 human;1 mouse;1 zebrafish
HCOP

vertebrate homology predictions: GAS5
Gene Tree

Gas5

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Phenotype Summary

9 phenotypes from 1 allele in 1 genetic background
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

167
Chemically induced (other)

2
Endonuclease-mediated

7
Gene trapped

158
Genomic Mutations

2 involving Gas5
Find Mice (IMSR)

65 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele die during the embryonic period. Heterozygous mice develop osteoporosis and have impaired bone repair capacity.

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All GO Annotations

6
GO References

2

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

No experimental evidence to support Cellular Component annotation, following literature review. See J:73796.

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

833
Tissues

120
cDNA Data

14
Literature Summary

11

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

194
RefSeq

8
UniProt

2

Ensembl

ENSMUSG00000053332 (Evidence)
NCBI Gene

14455

			Length	Strain/Species	Flank
genomic	14455	NCBI Gene Model \| MGI Sequence Detail	3939	C57BL/6J	± kb
transcript	NR_166052	RefSeq \| MGI Sequence Detail	550	C57BL/6
polypeptide	V9H1D0	UniProt \| EBI \| MGI Sequence Detail	41	Not Applicable

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UniProt

2 Sequences

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All nucleic 21

cDNA 14

Primer pair 6

Other 1

Microarray probesets 6

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MGD-MRK-9990, MGD-MRK-9996

Summaries

All 51

Developmental Gene Expression 11

Gene Ontology 2

Phenotypes 13
Earliest

J:9302 Schneider C, et al., Genes specifically expressed at growth arrest of mammalian cells. Cell. 1988 Sep 9;54(6):787-93
Latest

J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

TSS for Gas5:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr9671	Chr1:160862151-160862184 (+)	-3 bp
Tssr9672	Chr1:160862473-160862491 (+)	311 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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