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Gcg Gene Detail
Summary
  • Symbol
    Gcg
  • Name
    glucagon
  • Synonyms
    GLP-1, Glu, glucagon-like peptide I, PPG
  • Feature Type
    protein coding gene
  • IDs
    MGI:95674
    NCBI Gene: 14526
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
  • Candidate for QTL
    2 QTL
Location &
Maps
more
  • Sequence Map
    Chr2:62304874-62313994 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 35.85 cM
  • Mapping Data
    20 experiments
Strain
Comparison
more
  • SNPs within 2kb
    270 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    5
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95674
 protein coding gene Chr2:62304874-62313997 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025770
 protein coding gene Chr2:62158707-62167840 (-)
A/J MGP_AJ_G0025746
 protein coding gene Chr2:59780509-59789629 (-)
AKR/J MGP_AKRJ_G0025716
 protein coding gene Chr2:61380099-61389219 (-)
BALB/cJ MGP_BALBcJ_G0025741
 protein coding gene Chr2:59889107-59898227 (-)
C3H/HeJ MGP_C3HHeJ_G0025502
 protein coding gene Chr2:61490060-61499179 (-)
C57BL/6NJ MGP_C57BL6NJ_G0026188
 protein coding gene Chr2:63983335-63992565 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023592
 protein coding gene Chr2:57300061-57309175 (-)
CAST/EiJ MGP_CASTEiJ_G0024966
 protein coding gene Chr2:61560947-61571182 (-)
CBA/J MGP_CBAJ_G0025482
 protein coding gene Chr2:66407178-66416296 (-)
DBA/2J MGP_DBA2J_G0025613
 protein coding gene Chr2:59363033-59372165 (-)
FVB/NJ MGP_FVBNJ_G0025575
 protein coding gene Chr2:58883024-58892374 (-)
LP/J MGP_LPJ_G0025701
 protein coding gene Chr2:61993067-62002185 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0025606
 protein coding gene Chr2:68108497-68120711 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0026245
 protein coding gene Chr2:61450985-61460105 (-)
PWK/PhJ MGP_PWKPhJ_G0024707
 protein coding gene Chr2:59228079-59237396 (-)
SPRET/EiJ MGP_SPRETEiJ_G0024514
 protein coding gene Chr2:61601476-61610631 (-)
WSB/EiJ MGP_WSBEiJ_G0025034
 protein coding gene Chr2:61768768-61779496 (-)



Homology
more
  • Human Ortholog
    GCG, glucagon
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GCG, glucagon
  • Synonyms
    GLP-1, GLP1, GLP2, GRPP
  • Links
    NCBI Gene ID: 2641
    neXtProt AC: NX_P01275
    UniProt: P01275

  • Chr Location
    2q24.2; chr2:162142882-162152404 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with human GCG associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 2 alleles in 2 genetic backgrounds
    71 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit islet alpha cell hyperplasia and increased body weight.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    37
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1296
  • Tissues
    136
  • cDNA Data
    36
  • Literature Summary
    487
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000000394 Ensembl Gene Model | MGI Sequence Detail 9121 C57BL/6J ±  kb
    transcript ENSMUST00000102733 Ensembl | MGI Sequence Detail 1088 Not Applicable  
    polypeptide ENSMUSP00000099794 Ensembl | MGI Sequence Detail 180 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 55
      cDNA 39
      Primer pair 16

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-10020
    References
    more
    • Summaries
      All 725
      Developmental Gene Expression 487
      Gene Ontology 13
      Phenotypes 71
    • Earliest
      J:8667 Lalley PA, et al., Mapping polypeptide hormone genes in the mouse: somatostatin, glucagon, calcitonin, and parathyroid hormone. Cytogenet Cell Genet. 1987;44(2-3):92-7
    • Latest
      J:355694 Davidson RK, et al., The SWI/SNF chromatin remodelling complex regulates pancreatic endocrine cell expansion and differentiation in mice in vivo. Diabetologia. 2024 Oct;67(10):2275-2288
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory