Gdf10 MGI Mouse Gene Detail - MGI:95684 - growth differentiation factor 10

Symbol

Gdf10
Name

growth differentiation factor 10
Synonyms

Bmp3b

Feature Type

protein coding gene
IDs

MGI:95684
NCBI Gene: 14560
Alliance

gene page
Transcription Start Sites

11 TSS

Sequence Map

Chr14:33645544-33658471 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 14, 20.80 cM
Mapping Data

2 experiments

SNPs within 2kb

482 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_95684	protein coding gene	Chr14:33645544-33659940 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0021159	protein coding gene	Chr14:27254327-27267425 (+)
A/J	MGP_AJ_G0021107	protein coding gene	Chr14:26200775-26212468 (+)
AKR/J	MGP_AKRJ_G0021084	protein coding gene	Chr14:27362518-27374212 (+)
BALB/cJ	MGP_BALBcJ_G0021111	protein coding gene	Chr14:26384523-26396216 (+)
C3H/HeJ	MGP_C3HHeJ_G0020894	protein coding gene	Chr14:27267033-27278729 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0021543	protein coding gene	Chr14:28299965-28311658 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019105	protein coding gene	Chr14:26239698-26251451 (+)
CAST/EiJ	MGP_CASTEiJ_G0020419	protein coding gene	Chr14:27098939-27111238 (+)
CBA/J	MGP_CBAJ_G0020861	protein coding gene	Chr14:29336251-29347944 (+)
DBA/2J	MGP_DBA2J_G0020983	protein coding gene	Chr14:26237665-26249364 (+)
FVB/NJ	MGP_FVBNJ_G0020967	protein coding gene	Chr14:26191748-26203440 (+)
LP/J	MGP_LPJ_G0021052	protein coding gene	Chr14:27588881-27602497 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020993	protein coding gene	Chr14:28494037-28506895 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021576	protein coding gene	Chr14:27192609-27204303 (+)
PWK/PhJ	MGP_PWKPhJ_G0020167	protein coding gene	Chr14:25728775-25741048 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0019991	protein coding gene	Chr14:26809242-26822280 (+)
WSB/EiJ	MGP_WSBEiJ_G0020474	protein coding gene	Chr14:27258202-27271074 (+)

Human Ortholog

GDF10, growth differentiation factor 10

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

GDF10, growth differentiation factor 10
Synonyms

BIP, BMP-3b, BMP3B
Links

HGNC:4215

NCBI Gene ID: 2662

neXtProt AC: NX_P55107

UniProt: P55107
Chr Location

10q11.22; chr10:47300197-47313577 (+) GRCh38

MGI Vertebrate Homology

Gdf10 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: GDF10
Protein SuperFamily

BMP3/GDF10
Gene Tree

Gdf10

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Phenotype Summary

5 phenotypes from 2 alleles in 2 genetic backgrounds
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Targeted

6
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

31 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for disruption of this gene display a normal phenotype.

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All GO Annotations

18
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1130
Tissues

134
cDNA Data

25
Literature Summary

36

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

GEISHA GDF10

Xenbase gdf10

ZFIN gdf10a

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All Sequences

34
RefSeq

2
UniProt

4
CCDS

CCDS26927.1

Ensembl

ENSMUSG00000021943 (Evidence)
NCBI Gene

14560

			Length	Strain/Species	Flank
genomic	14560	NCBI Gene Model \| MGI Sequence Detail	12928	C57BL/6J	± kb
transcript	NM_145741	RefSeq \| MGI Sequence Detail	3741	ZRU/MplStud
polypeptide	P97737	UniProt \| EBI \| MGI Sequence Detail	476	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000007918 bone morphogenetic protein 3B

(term hierarchy)
InterPro Domains

IPR017197 Bone morphogenetic protein 3/3B

IPR029034 Cystine-knot cytokine

IPR017948 Transforming growth factor beta, conserved site

IPR001839 Transforming growth factor-beta, C-terminal

IPR015615 Transforming growth factor-beta-related
GlyGen

P97737 4 sites, 3 N-linked glycans (3 sites)

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All nucleic 34

Genomic 1

cDNA 25

Primer pair 6

Other 2

Microarray probesets 3

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MGD-MRK-10037

Summaries

All 72

Developmental Gene Expression 36

Gene Ontology 6

Phenotypes 12
Earliest

J:29417 Cunningham NS, et al., Growth/differentiation factor-10: a new member of the transforming growth factor-beta superfamily related to bone morphogenetic protein-3. Growth Factors. 1995;12(2):99-109
Latest

J:358015 Platko K, et al., GDF10 is a negative regulator of vascular calcification. J Biol Chem. 2024 Sep 21;300(11):107805

TSS for Gdf10:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr125039	Chr14:33645272-33645286 (+)	-265 bp
Tssr125040	Chr14:33645287-33645310 (+)	-245 bp
Tssr125041	Chr14:33645312-33645321 (+)	-227 bp
Tssr125042	Chr14:33645385-33645423 (+)	-140 bp
Tssr125043	Chr14:33645440-33645456 (+)	-96 bp
Tssr125044	Chr14:33645539-33645559 (+)	5 bp
Tssr125045	Chr14:33645567-33645594 (+)	37 bp
Tssr125046	Chr14:33645600-33645642 (+)	77 bp
Tssr125047	Chr14:33645646-33645657 (+)	108 bp
Tssr125048	Chr14:33645757-33645769 (+)	219 bp
Tssr125049	Chr14:33656823-33656836 (+)	11,286 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24