Gpr83 MGI Mouse Gene Detail - MGI:95712 - G protein-coupled receptor 83

Symbol

Gpr83
Name

G protein-coupled receptor 83
Synonyms

Gir, GIR, glucocorticoid-induced receptor, Gpr72, RP105, RP39, RP82

Feature Type

protein coding gene
IDs

MGI:95712
NCBI Gene: 14608
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr9:14771506-14782085 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 4.40 cM, cytoband A2-A3
Mapping Data

6 experiments

SNPs within 2kb

349 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_95712	protein coding gene	Chr9:14771038-14782085 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0034357	protein coding gene	Chr9:11822559-11833138 (+)
A/J	MGP_AJ_G0034335	protein coding gene	Chr9:11766779-11777358 (+)
AKR/J	MGP_AKRJ_G0034263	protein coding gene	Chr9:11773032-11783611 (+)
BALB/cJ	MGP_BALBcJ_G0034329	protein coding gene	Chr9:11537023-11547594 (+)
C3H/HeJ	MGP_C3HHeJ_G0034040	protein coding gene	Chr9:12079214-12089793 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0034851	protein coding gene	Chr9:12205441-12216020 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0031789	protein coding gene	Chr9:11064885-11075513 (+)
CAST/EiJ	MGP_CASTEiJ_G0033367	protein coding gene	Chr9:11921138-11988840 (+)
CBA/J	MGP_CBAJ_G0034013	protein coding gene	Chr9:12774473-12785052 (+)
DBA/2J	MGP_DBA2J_G0034170	protein coding gene	Chr9:11641113-11651692 (+)
FVB/NJ	MGP_FVBNJ_G0034115	protein coding gene	Chr9:11233475-11244054 (+)
LP/J	MGP_LPJ_G0034256	protein coding gene	Chr9:11917078-11927657 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0034159	protein coding gene	Chr9:13813841-13824420 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0034870	protein coding gene	Chr9:11793021-11803596 (+)
PWK/PhJ	MGP_PWKPhJ_G0033073	protein coding gene	Chr9:11714131-11725317 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0032909	protein coding gene	Chr9:11887564-11898151 (+)
WSB/EiJ	MGP_WSBEiJ_G0033483	protein coding gene	Chr9:11642883-11654923 (+)

Human Ortholog

GPR83, G protein-coupled receptor 83

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

GPR83, G protein-coupled receptor 83
Synonyms

GIR, GPR72
Links

HGNC:4523

NCBI Gene ID: 10888

neXtProt AC: NX_Q9NYM4

UniProt: Q9NYM4
Chr Location

11q21; chr11:94377316-94401419 (-) GRCh38

MGI Vertebrate Homology

Gpr83 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: GPR83
Gene Tree

Gpr83

less

Phenotype Summary

21 phenotypes from 4 alleles in 4 genetic backgrounds
17 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

13
Endonuclease-mediated

5
Targeted

8
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

26 strains or lines available
Comparison Matrix

Gene Expression + Phenotype
Recombinase Activity

Comparison Matrix Gene Expression + Recombinase Activity

Mice homozygous for a null allele exhibit normal regulatory T cell development. Mice homozygous for a different targeted allele exhibit attenuated stress-evoked anxiety, increased sucrose preference and delayed spatial learning.

less

All GO Annotations

15
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

862
Tissues

107
cDNA Data

14
Literature Summary

6

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

GEISHA GPR83

Xenbase gpr83, gpr83.2

less

All Sequences

45
RefSeq

8
UniProt

1
CCDS

CCDS22829.1, CCDS80959.1

Ensembl

ENSMUSG00000031932 (Evidence)
NCBI Gene

14608

			Length	Strain/Species	Flank
genomic	ENSMUSG00000031932	Ensembl Gene Model \| MGI Sequence Detail	10580	C57BL/6J	± kb
transcript	ENSMUST00000034408	Ensembl \| MGI Sequence Detail	3586	Not Applicable
polypeptide	ENSMUSP00000034408	Ensembl \| MGI Sequence Detail	423	Not Applicable

less

UniProt

1 Sequence
Protein Ontology

PR:000001539 G-protein coupled receptor 83

(term hierarchy)
InterPro Domains

IPR017452 GPCR, rhodopsin-like, 7TM

IPR000276 G protein-coupled receptor, rhodopsin-like

IPR000611 Neuropeptide Y receptor family
GlyGen

P30731 3 sites

less

All nucleic 19

Genomic 1

cDNA 15

Primer pair 2

Other 1

Microarray probesets 5

less

MGD-MRK-10078, MGI:2143277

Summaries

All 53

Developmental Gene Expression 6

Gene Ontology 6

Phenotypes 17
Earliest

J:1663 Harrigan MT, et al., Identification of a gene induced by glucocorticoids in murine T-cells: a potential G protein-coupled receptor. Mol Endocrinol. 1991 Sep;5(9):1331-8
Latest

J:353123 Zhang D, et al., C-LTMRs mediate wet dog shakes via the spinoparabrachial pathway. bioRxiv. 2024 Jun 11;

TSS for Gpr83:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr83849	Chr9:14769766-14769774 (+)	-1,736 bp
Tssr83850	Chr9:14771528-14771542 (+)	29 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24