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Hagh Gene Detail
Summary
  • Symbol
    Hagh
  • Name
    hydroxyacyl glutathione hydrolase
  • Synonyms
    Glo-2, Glo2, Rsp29
  • Feature Type
    protein coding gene
  • IDs
    MGI:95745
    NCBI Gene: 14651
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
  • Candidate for QTL
    4 QTL
Location &
Maps
more
  • Sequence Map
    Chr17:25059117-25083424 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 12.53 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    711 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95745
 protein coding gene Chr17:25056863-25083424 (+)
129S1/SvImJ MGP_129S1SvImJ_G0023325
 protein coding gene Chr17:23876233-23889930 (+)
A/J MGP_AJ_G0023285
 protein coding gene Chr17:23212905-23226649 (+)
AKR/J MGP_AKRJ_G0023252
 protein coding gene Chr17:23301445-23315197 (+)
BALB/cJ MGP_BALBcJ_G0023290
 protein coding gene Chr17:23413501-23427209 (+)
C3H/HeJ MGP_C3HHeJ_G0023050
 protein coding gene Chr17:23664688-23678388 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023733
 protein coding gene Chr17:24937895-24952796 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021207
 protein coding gene Chr17:20663792-20688455 (+)
CAST/EiJ MGP_CASTEiJ_G0022552
 protein coding gene Chr17:23520945-23534717 (+)
CBA/J MGP_CBAJ_G0023026
 protein coding gene Chr17:25780372-25794070 (+)
DBA/2J MGP_DBA2J_G0023155
 protein coding gene Chr17:22805225-22818971 (+)
FVB/NJ MGP_FVBNJ_G0023125
 protein coding gene Chr17:22525743-22539771 (+)
LP/J MGP_LPJ_G0023232
 protein coding gene Chr17:24180482-24195010 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023144
 protein coding gene Chr17:25471415-25485447 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023771
 protein coding gene Chr17:23585928-23599674 (+)
PWK/PhJ MGP_PWKPhJ_G0022301
 protein coding gene Chr17:21560614-21574776 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022115
 protein coding gene Chr17:21619085-21664040 (+)
WSB/EiJ MGP_WSBEiJ_G0022615
 protein coding gene Chr17:23658637-23672296 (+)



Homology
more
  • Human Ortholog
    HAGH, hydroxyacylglutathione hydrolase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HAGH, hydroxyacylglutathione hydrolase
  • Synonyms
    GLO2, GLO2D, GLX2, GLXII, HAGH1
  • Links
    NCBI Gene ID: 3029
    neXtProt AC: NX_Q16775
    UniProt: Q16775

  • Chr Location
    16p13.3; chr16:1795620-1827194 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    15
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    800
  • Tissues
    94
  • cDNA Data
    119
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000024158 Ensembl Gene Model | MGI Sequence Detail 24308 C57BL/6J ±  kb
    transcript ENSMUST00000118788 Ensembl | MGI Sequence Detail 1191 Not Applicable  
    polypeptide ENSMUSP00000113051 Ensembl | MGI Sequence Detail 309 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 120
      cDNA 119
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-10123, MGD-MRK-10127, MGD-MRK-10610, MGI:3039638
    References
    more
    • Summaries
      All 37
      Developmental Gene Expression 1
      Gene Ontology 8
      Phenotypes 7
    • Earliest
      J:7470 Bonhomme F, et al., Biochemical diversity and evolution in the genus Mus. Biochem Genet. 1984 Apr;22(3-4):275-303
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory