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Glrb Gene Detail
Summary
  • Symbol
    Glrb
  • Name
    glycine receptor, beta subunit
  • Feature Type
    protein coding gene
  • IDs
    MGI:95751
    NCBI Gene: 14658
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:80750906-80820967 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 35.71 cM, cytoband E3-F1
  • Mapping Data
    18 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2461 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95751
 protein coding gene Chr3:80750905-80820994 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027320
 protein coding gene Chr3:80601628-80674459 (-)
A/J MGP_AJ_G0027282
 protein coding gene Chr3:77936896-78007745 (-)
AKR/J MGP_AKRJ_G0027250
 protein coding gene Chr3:79748194-79818052 (-)
BALB/cJ MGP_BALBcJ_G0027293
 protein coding gene Chr3:78003583-78073322 (-)
C3H/HeJ MGP_C3HHeJ_G0027037
 protein coding gene Chr3:80082581-80154367 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027739
 protein coding gene Chr3:83682854-83752407 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025092
 protein coding gene Chr3:73763774-73832528 (-)
CAST/EiJ MGP_CASTEiJ_G0026484
 protein coding gene Chr3:80186829-80258787 (-)
CBA/J MGP_CBAJ_G0027012
 protein coding gene Chr3:86441487-86521295 (-)
DBA/2J MGP_DBA2J_G0027148
 protein coding gene Chr3:77486411-77556792 (-)
FVB/NJ MGP_FVBNJ_G0027116
 protein coding gene Chr3:75821875-75893935 (-)
LP/J MGP_LPJ_G0027256
 protein coding gene Chr3:81595225-81666618 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027135
 protein coding gene Chr3:92754981-92828676 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027797
 protein coding gene Chr3:79581438-79661754 (-)
PWK/PhJ MGP_PWKPhJ_G0026218
 protein coding gene Chr3:77242270-77312310 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026034
 protein coding gene Chr3:78775029-78844907 (-)
WSB/EiJ MGP_WSBEiJ_G0026562
 protein coding gene Chr3:79921635-79996030 (-)



Homology
more
  • Human Ortholog
    GLRB, glycine receptor beta
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GLRB, glycine receptor beta
  • Synonyms
    HKPX2
  • Links
    NCBI Gene ID: 2743
    neXtProt AC: NX_P48167
    UniProt: P48167

  • Chr Location
    4q32.1; chr4:157076125-157172090 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Glrb mouse models; 1 with human GLRB associations

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    40 phenotypes from 3 alleles in 5 genetic backgrounds
    7 phenotypes from multigenic genotypes
    41 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mutations in this gene result in a neurological disorder and premature death.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    61
  • GO References
    23
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    843
  • Tissues
    121
  • cDNA Data
    14
  • Literature Summary
    10
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000028020 Ensembl Gene Model | MGI Sequence Detail 70062 C57BL/6J ±  kb
    transcript ENSMUST00000029654 Ensembl | MGI Sequence Detail 3029 Not Applicable  
    polypeptide ENSMUSP00000029654 Ensembl | MGI Sequence Detail 496 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • Protein Ontology
      PR:000008046 glycine receptor subunit beta
      (term hierarchy)
    • InterPro Domains
      IPR008060 Glycine receptor beta
      IPR047031 Glycine receptor subunit beta, extracellular domain
      IPR047029 Glycine receptor subunit beta, transmembrane domain
      IPR038050 Neuronal acetylcholine receptor
      IPR006201 Neurotransmitter-gated ion-channel
      IPR018000 Neurotransmitter-gated ion-channel, conserved site
      IPR006202 Neurotransmitter-gated ion-channel ligand-binding domain
      IPR036734 Neurotransmitter-gated ion-channel ligand-binding domain superfamily
      IPR006029 Neurotransmitter-gated ion-channel transmembrane domain
      IPR036719 Neurotransmitter-gated ion-channel transmembrane domain superfamily
    • GlyGen
      P48168 3 sites, 4 N-linked glycans (2 sites), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 29
      Genomic 7
      cDNA 17
      Primer pair 3
      Other 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-10134, MGD-MRK-14513, MGI:2139832
    References
    more
    • Summaries
      All 89
      Developmental Gene Expression 10
      Diseases 2
      Gene Ontology 23
      Phenotypes 41
    • Earliest
      J:13079 Chai CK, Hereditary spasticity in mice. J Hered. 1961;52(5):241-243
    • Latest
      J:346212 Wiessler AL, et al., Role of the Glycine Receptor beta Subunit in Synaptic Localization and Pathogenicity in Severe Startle Disease. J Neurosci. 2024 Jan 10;44(2)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory