Gls MGI Mouse Gene Detail - MGI:95752

Symbol

Gls
Name

glutaminase
Synonyms

B230365M23Rik

Feature Type

protein coding gene
IDs

MGI:95752
NCBI Gene: 14660
Alliance

gene page
Transcription Start Sites

10 TSS

Sequence Map

Chr1:52202607-52272391 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 26.86 cM
Mapping Data

23 experiments

SNPs within 2kb

1569 from dbSNP Build 142
Strain Annotations

18
PCR

1
RFLP

5

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_95752	protein coding gene	Chr1:52202607-52274168 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0016007	protein coding gene	Chr1:51673367-51743091 (-)
A/J	MGP_AJ_G0015989	protein coding gene	Chr1:49943585-50012965 (-)
AKR/J	MGP_AKRJ_G0015945	protein coding gene	Chr1:50996317-51067415 (-)
BALB/cJ	MGP_BALBcJ_G0015946	protein coding gene	Chr1:49759325-49829145 (-)
C3H/HeJ	MGP_C3HHeJ_G0015778	protein coding gene	Chr1:51404778-51476550 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0016397	protein coding gene	Chr1:53844333-53930651 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014127	protein coding gene	Chr1:41843246-41913074 (+)
CAST/EiJ	MGP_CASTEiJ_G0015359	protein coding gene	Chr1:50883414-50954625 (-)
CBA/J	MGP_CBAJ_G0015749	protein coding gene	Chr1:55279312-55357715 (-)
DBA/2J	MGP_DBA2J_G0015850	protein coding gene	Chr1:49195146-49264685 (-)
FVB/NJ	MGP_FVBNJ_G0015852	protein coding gene	Chr1:48659895-48730980 (-)
LP/J	MGP_LPJ_G0015921	protein coding gene	Chr1:52168861-52241042 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0015872	protein coding gene	Chr1:58307146-58413265 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0016445	protein coding gene	Chr1:51128884-51200578 (-)
PWK/PhJ	MGP_PWKPhJ_G0015145	protein coding gene	Chr1:49076483-49147944 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0014925	protein coding gene	Chr1:50781744-50855311 (-)
WSB/EiJ	MGP_WSBEiJ_G0015422	protein coding gene	Chr1:50938562-51010614 (-)

Human Ortholog

GLS, glutaminase

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

GLS, glutaminase
Synonyms

AAD20, CASGID, DEE71, EIEE71, GAC, GAM, GDPAG, GLS1, KGA
Links

HGNC:4331

NCBI Gene ID: 2744

neXtProt AC: NX_O94925

UniProt: O94925
Chr Location

2q32.2; chr2:190880821-190965552 (+) GRCh38

MGI Vertebrate Homology

Gls stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: GLS
Gene Tree

Gls

Diseases

1 with human GLS associations

				Human Disease	Mouse Models
				developmental and epileptic encephalopathy 71 IDs developmental and epileptic encephalopathy 71 DOID:0112207 OMIM:618328

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

9 phenotypes from 4 alleles in 5 genetic backgrounds
40 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

16
Chemically induced (other)

1
Endonuclease-mediated

7
Gene trapped

2
Radiation induced

1
Targeted

5
Genomic Mutations

2 involving Gls
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

44 strains or lines available

Homozygotes for targeted null mutations die within 1 day postnatally with abnormal respiratory function and goal-oriented behavior toward dam. Mice homozygous for another allele exhibit abnormal TNFA-stimulated astrocyte extracellular vesicle release.

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All GO Annotations

24
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

824
Tissues

107
cDNA Data

212
Literature Summary

10

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase gls

ZFIN glsa, glsb

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All Sequences

83
RefSeq

14
UniProt

5
CCDS

CCDS35561.1, CCDS48256.1

Ensembl

ENSMUSG00000026103 (Evidence)
NCBI Gene

14660

			Length	Strain/Species	Flank
genomic	ENSMUSG00000026103	Ensembl Gene Model \| MGI Sequence Detail	69785	C57BL/6J	± kb
transcript	ENSMUST00000114513	Ensembl \| MGI Sequence Detail	4966	Not Applicable
polypeptide	ENSMUSP00000110158	Ensembl \| MGI Sequence Detail	674	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000008051 glutaminase kidney isoform, mitochondrial

(term hierarchy)
PDB

3SS3, 3SS4, 3SS5, 4JKT, 5W2J, 8EC6
EC

3.5.1.2
InterPro Domains

IPR002110 Ankyrin repeat

IPR036770 Ankyrin repeat-containing domain superfamily

IPR012338 Beta-lactamase/transpeptidase-like

IPR015868 Glutaminase

IPR041541 Glutaminase, EF-hand domain
GlyGen

D3Z7P3 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)

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All nucleic 224

Genomic 4

cDNA 214

Primer pair 5

Other 1

Microarray probesets 7

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MGD-MRK-10135, MGI:2138193, MGI:2444416

Summaries

All 103

Developmental Gene Expression 10

Gene Ontology 9

Phenotypes 40
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:358517 Li M, et al., AMPK targets PDZD8 to trigger carbon source shift from glucose to glutamine. Cell Res. 2024 Oct;34(10):683-706

TSS for Gls:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr11602	Chr1:52272370-52272388 (-)	12 bp
Tssr11601	Chr1:52272234-52272256 (-)	146 bp
Tssr11600	Chr1:52272165-52272191 (-)	213 bp
Tssr11599	Chr1:52272140-52272157 (-)	242 bp
Tssr11598	Chr1:52271560-52271591 (-)	815 bp
Tssr11597	Chr1:52230088-52230090 (-)	42,302 bp
Tssr11596	Chr1:52230060-52230074 (-)	42,324 bp
Tssr11595	Chr1:52203997-52204018 (-)	68,383 bp
Tssr11594	Chr1:52203872-52203883 (-)	68,513 bp
Tssr11593	Chr1:52203822-52203838 (-)	68,561 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24