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Gna11 Gene Detail
Summary
  • Symbol
    Gna11
  • Name
    guanine nucleotide binding protein, alpha 11
  • Synonyms
    Dsk7
  • Feature Type
    protein coding gene
  • IDs
    MGI:95766
    NCBI Gene: 14672
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:81364558-81380996 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 39.72 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    377 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95766
 protein coding gene Chr10:81364558-81381024 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017564
 protein coding gene Chr10:82254924-82272906 (-)
A/J MGP_AJ_G0017542
 protein coding gene Chr10:79335090-79351782 (-)
AKR/J MGP_AKRJ_G0017503
 protein coding gene Chr10:81511421-81527822 (-)
BALB/cJ MGP_BALBcJ_G0017504
 protein coding gene Chr10:79556986-79575530 (-)
C3H/HeJ MGP_C3HHeJ_G0017327
 protein coding gene Chr10:81615926-81633183 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017958
 protein coding gene Chr10:85075434-85091871 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015647
 protein coding gene Chr10:75531517-75548098 (-)
CAST/EiJ MGP_CASTEiJ_G0016894
 protein coding gene Chr10:81857192-81875834 (-)
CBA/J MGP_CBAJ_G0017299
 protein coding gene Chr10:88414622-88431038 (-)
DBA/2J MGP_DBA2J_G0017405
 protein coding gene Chr10:78539332-78556043 (-)
FVB/NJ MGP_FVBNJ_G0017399
 protein coding gene Chr10:77800684-77818044 (-)
LP/J MGP_LPJ_G0017476
 protein coding gene Chr10:82707093-82723541 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017425
 protein coding gene Chr10:90240948-90258497 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017999
 protein coding gene Chr10:81527913-81547775 (-)
PWK/PhJ MGP_PWKPhJ_G0016675
 protein coding gene Chr10:78444867-78461601 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016465
 protein coding gene Chr10:80476772-80493482 (-)
WSB/EiJ MGP_WSBEiJ_G0016954
 protein coding gene Chr10:81573032-81589445 (-)



Homology
more
  • Human Ortholog
    GNA11, G protein subunit alpha 11
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GNA11, G protein subunit alpha 11
  • Synonyms
    FBH, FBH2, FHH2, GNA-11, HG1K, HHC2, HYPOC2
  • Links
    NCBI Gene ID: 2767
    neXtProt AC: NX_P29992
    UniProt: P29992

  • Chr Location
    19p13.3; chr19:3094362-3123999 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Gna11 mouse models; 2 with human GNA11 associations

Human Disease Mouse Models
      
IDs
 View 2 models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    33 phenotypes from 5 alleles in 7 genetic backgrounds
    75 phenotypes from multigenic genotypes
    87 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    55
  • GO References
    22
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    767
  • Tissues
    40
  • cDNA Data
    12
  • Literature Summary
    10
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14672 NCBI Gene Model | MGI Sequence Detail 16439 C57BL/6J ±  kb
    transcript NM_010301 RefSeq | MGI Sequence Detail 3404 ZRU/MplStud  
    polypeptide P21278 UniProt | EBI | MGI Sequence Detail 359 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000008080 guanine nucleotide-binding protein subunit alpha-11
      (term hierarchy)
    • InterPro Domains
      IPR000654 G-protein alpha subunit, group Q
      IPR011025 G protein alpha subunit, helical insertion
      IPR001019 Guanine nucleotide binding protein (G-protein), alpha subunit
      IPR027417 P-loop containing nucleoside triphosphate hydrolase
    • GlyGen
      P21278 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 25
      Genomic 8
      cDNA 12
      Primer pair 4
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-10175, MGI:2450689
    References
    more
    • Summaries
      All 147
      Developmental Gene Expression 10
      Diseases 1
      Gene Ontology 22
      Phenotypes 87
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/17/2024
    MGI 6.24     		The Jackson Laboratory