Gnai1 MGI Mouse Gene Detail - MGI:95771 - G protein subunit alpha i1

Symbol

Gnai1
Name

G protein subunit alpha i1
Synonyms

Gialpha1

Feature Type

protein coding gene
IDs

MGI:95771
NCBI Gene: 14677
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr5:18470133-18565353 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 8.16 cM
Mapping Data

7 experiments

SNPs within 2kb

2576 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_95771	protein coding gene	Chr5:18470133-18565411 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0029308	protein coding gene	Chr5:15681707-15781565 (-)
A/J	MGP_AJ_G0029273	protein coding gene	Chr5:15201316-15291655 (-)
AKR/J	MGP_AKRJ_G0029224	protein coding gene	Chr5:15838585-15929185 (-)
BALB/cJ	MGP_BALBcJ_G0029285	protein coding gene	Chr5:15634130-15721950 (-)
C3H/HeJ	MGP_C3HHeJ_G0029004	protein coding gene	Chr5:15842347-15936449 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0029738	protein coding gene	Chr5:16986640-17089009 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0026977	protein coding gene	Chr5:13459566-13538095 (-)
CAST/EiJ	MGP_CASTEiJ_G0028416	protein coding gene	Chr5:15209138-15300500 (-)
CBA/J	MGP_CBAJ_G0028971	protein coding gene	Chr5:17054135-17159112 (-)
DBA/2J	MGP_DBA2J_G0029123	protein coding gene	Chr5:15497754-15588587 (-)
FVB/NJ	MGP_FVBNJ_G0029081	protein coding gene	Chr5:14917882-15014772 (-)
LP/J	MGP_LPJ_G0029207	protein coding gene	Chr5:16110215-16221315 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0029109	protein coding gene	Chr5:18200250-18304055 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0029771	protein coding gene	Chr5:15473642-15569484 (-)
PWK/PhJ	MGP_PWKPhJ_G0028138	protein coding gene	Chr5:14544864-14633719 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0027971	protein coding gene	Chr5:14842263-14935390 (-)
WSB/EiJ	MGP_WSBEiJ_G0028496	protein coding gene	Chr5:15486249-15576896 (-)

Human Ortholog

GNAI1, G protein subunit alpha i1

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

GNAI1, G protein subunit alpha i1
Synonyms

Gi, HG1B, NEDHISB
Links

HGNC:4384

NCBI Gene ID: 2770

neXtProt AC: NX_P63096

UniProt: P63096
Chr Location

7q21.11; chr7:79768028-80226181 (+) GRCh38

MGI Vertebrate Homology

Gnai1 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: GNAI1
Gene Tree

Gnai1

less

References

1 with disease annotations

less

Phenotype Summary

7 phenotypes from 2 alleles in 2 genetic backgrounds
9 phenotypes from multigenic genotypes
1 images
35 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Chemically induced (other)

2
Endonuclease-mediated

2
Radiation induced

1
Spontaneous

1
Targeted

6
Genomic Mutations

4 involving Gnai1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

15 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for disruptions in this gene exhibit long term memory defects.

less

All GO Annotations

73
GO References

12

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

778
Tissues

41
cDNA Data

55
Literature Summary

16

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA GNAI1

Xenbase gnai1

ZFIN gnai1

less

All Sequences

39
RefSeq

2
UniProt

2
CCDS

CCDS39018.1

Ensembl

ENSMUSG00000057614 (Evidence)
NCBI Gene

14677

			Length	Strain/Species	Flank
genomic	ENSMUSG00000057614	Ensembl Gene Model \| MGI Sequence Detail	95221	C57BL/6J	± kb
transcript	ENSMUST00000074694	Ensembl \| MGI Sequence Detail	3135	Not Applicable
polypeptide	ENSMUSP00000074259	Ensembl \| MGI Sequence Detail	354	Not Applicable

less

UniProt

2 Sequences
Protein Ontology

PR:000008085 guanine nucleotide-binding protein G(i) subunit alpha-1

(term hierarchy)
PDB

7TD0, 7TD1, 7TD2, 7TD3, 7TD4, 8FX5
EC

3.6.5.-
InterPro Domains

IPR001408 G-protein alpha subunit, group I

IPR011025 G protein alpha subunit, helical insertion

IPR001019 Guanine nucleotide binding protein (G-protein), alpha subunit

IPR027417 P-loop containing nucleoside triphosphate hydrolase
GlyGen

B2RSH2 2 sites, 1 O-linked glycan (2 sites)

less

All nucleic 62

cDNA 57

Primer pair 4

Other 1

Microarray probesets 8

less

MGD-MRK-10180, MGD-MRK-10183, MGI:2141096

Summaries

All 109

Developmental Gene Expression 16

Diseases 1

Gene Ontology 12

Phenotypes 35
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Gnai1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr50212	Chr5:18565382-18565471 (-)	-74 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/17/2024 MGI 6.24