Gnaz MGI Mouse Gene Detail - MGI:95780 - guanine nucleotide binding protein, alpha z subunit

Symbol

Gnaz
Name

guanine nucleotide binding protein, alpha z subunit
Synonyms

Gz

Feature Type

protein coding gene
IDs

MGI:95780
NCBI Gene: 14687
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr10:74803009-74852739 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 38.48 cM
Mapping Data

4 experiments

SNPs within 2kb

1347 from dbSNP Build 142
Strain Annotations

18
RFLP

2

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_95780	protein coding gene	Chr10:74803009-74852739 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0017349	protein coding gene	Chr10:75099286-75150247 (+)
A/J	MGP_AJ_G0017326	protein coding gene	Chr10:72525290-72576384 (+)
AKR/J	MGP_AKRJ_G0017287	protein coding gene	Chr10:74461636-74512756 (+)
BALB/cJ	MGP_BALBcJ_G0017286	protein coding gene	Chr10:72722581-72772994 (+)
C3H/HeJ	MGP_C3HHeJ_G0017110	protein coding gene	Chr10:74509412-74560508 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0017744	protein coding gene	Chr10:77767467-77820858 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015434	protein coding gene	Chr10:68994723-69044833 (+)
CAST/EiJ	MGP_CASTEiJ_G0016680	protein coding gene	Chr10:74816019-74867941 (+)
CBA/J	MGP_CBAJ_G0017082	protein coding gene	Chr10:80817166-80869261 (+)
DBA/2J	MGP_DBA2J_G0017187	protein coding gene	Chr10:71831537-71881954 (+)
FVB/NJ	MGP_FVBNJ_G0017180	protein coding gene	Chr10:70972754-71025243 (+)
LP/J	MGP_LPJ_G0017260	protein coding gene	Chr10:75589038-75641179 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017208	protein coding gene	Chr10:82939493-82993307 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017783	protein coding gene	Chr10:74496173-74549079 (+)
PWK/PhJ	MGP_PWKPhJ_G0016464	protein coding gene	Chr10:71628956-71680214 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0016247	protein coding gene	Chr10:73747894-73797575 (+)
WSB/EiJ	MGP_WSBEiJ_G0016744	protein coding gene	Chr10:74460556-74513631 (+)

Human Ortholog

GNAZ, G protein subunit alpha z

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

GNAZ, G protein subunit alpha z
Synonyms

gz-alpha, HG1H
Links

HGNC:4395

NCBI Gene ID: 2781

neXtProt AC: NX_P19086

UniProt: P19086
Chr Location

22q11.22-q11.23; chr22:23070519-23125032 (+) GRCh38

MGI Vertebrate Homology

Gnaz stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: GNAZ
Gene Tree

Gnaz

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Phenotype Summary

12 phenotypes from 3 alleles in 4 genetic backgrounds
2 phenotypes from multigenic genotypes
28 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Chemically induced (other)

1
Radiation induced

1
Targeted

8
Genomic Mutations

2 involving Gnaz
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

18 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit hypertolerance to morphine. Mice homozygous for a reporter allele exhibit impaired platelet aggregation, increased resistance to fatal thromboembolism, reduced morphine-elicited antinociception, and altered behavioral responses to addictive substances.

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All GO Annotations

27
GO References

12

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

877
Tissues

65
cDNA Data

14
Literature Summary

7

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase gnaz

ZFIN gnaz

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All Sequences

56
RefSeq

10
UniProt

3
CCDS

CCDS23922.1

Ensembl

ENSMUSG00000040009 (Evidence)
NCBI Gene

14687

			Length	Strain/Species	Flank
genomic	14687	NCBI Gene Model \| MGI Sequence Detail	49731	C57BL/6J	± kb
transcript	NM_010311	RefSeq \| MGI Sequence Detail	3605	C57BL/6
polypeptide	O70443	UniProt \| EBI \| MGI Sequence Detail	355	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000008094 guanine nucleotide-binding protein G(z) subunit alpha

(term hierarchy)
InterPro Domains

IPR001408 G-protein alpha subunit, group I

IPR011025 G protein alpha subunit, helical insertion

IPR001019 Guanine nucleotide binding protein (G-protein), alpha subunit

IPR027417 P-loop containing nucleoside triphosphate hydrolase
GlyGen

O70443 1 site, 1 O-linked glycan (1 site)

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All nucleic 19

cDNA 14

Primer pair 3

Other 2

Microarray probesets 4

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MGD-MRK-10194, MGI:2143685

Summaries

All 66

Developmental Gene Expression 7

Gene Ontology 12

Phenotypes 28
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Gnaz:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr94063	Chr10:74802916-74802930 (+)	-86 bp
Tssr94064	Chr10:74802959-74802994 (+)	-32 bp
Tssr94065	Chr10:74802996-74803035 (+)	7 bp
Tssr94066	Chr10:74814464-74814467 (+)	11,457 bp
Tssr94067	Chr10:74851140-74851164 (+)	48,143 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24