Gnb3 MGI Mouse Gene Detail - MGI:95785 - guanine nucleotide binding protein (G protein), beta 3

Symbol

Gnb3
Name

guanine nucleotide binding protein (G protein), beta 3

Feature Type

protein coding gene
IDs

MGI:95785
NCBI Gene: 14695
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr6:124811203-124817238 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 6, 59.17 cM
Mapping Data

14 experiments

SNPs within 2kb

198 from dbSNP Build 142
Strain Annotations

18
RFLP

3

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_95785	protein coding gene	Chr6:124811203-124817238 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0031272	protein coding gene	Chr6:128141027-128147063 (-)
A/J	MGP_AJ_G0031242	protein coding gene	Chr6:123320499-123326528 (-)
AKR/J	MGP_AKRJ_G0031170	protein coding gene	Chr6:126685696-126691722 (-)
BALB/cJ	MGP_BALBcJ_G0031250	protein coding gene	Chr6:122920390-122926419 (-)
C3H/HeJ	MGP_C3HHeJ_G0030973	protein coding gene	Chr6:126732843-126738870 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0031706	protein coding gene	Chr6:131524598-131530632 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0028856	protein coding gene	Chr6:120530680-120536738 (-)
CAST/EiJ	MGP_CASTEiJ_G0030354	protein coding gene	Chr6:126937351-126943378 (-)
CBA/J	MGP_CBAJ_G0030934	protein coding gene	Chr6:136556153-136562188 (-)
DBA/2J	MGP_DBA2J_G0031090	protein coding gene	Chr6:122247038-122253071 (-)
FVB/NJ	MGP_FVBNJ_G0031040	protein coding gene	Chr6:121149788-121155823 (-)
LP/J	MGP_LPJ_G0031170	protein coding gene	Chr6:128311804-128317836 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0031078	protein coding gene	Chr6:140615522-140621548 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0031741	protein coding gene	Chr6:126578579-126584608 (-)
PWK/PhJ	MGP_PWKPhJ_G0030069	protein coding gene	Chr6:120477990-120484067 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0029898	protein coding gene	Chr6:124663232-124669368 (-)
WSB/EiJ	MGP_WSBEiJ_G0030439	protein coding gene	Chr6:126938998-126945024 (-)

Human Ortholog

GNB3, G protein subunit beta 3

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

GNB3, G protein subunit beta 3
Synonyms

CSNB1H, HG2D
Links

HGNC:4400

NCBI Gene ID: 2784

neXtProt AC: NX_P16520

UniProt: P16520
Chr Location

12p13.31; chr12:6839954-6847393 (+) GRCh38

MGI Vertebrate Homology

Gnb3 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: GNB3
Protein SuperFamily

GN-bd_beta
Gene Tree

Gnb3

Diseases

7 with human GNB3 associations

				Human Disease	Mouse Models
				carotid artery disease IDs carotid artery disease DOID:3407 MESH:D002340 NCI:C84476 UMLS_CUI:C0007273
				congenital stationary night blindness 1H IDs congenital stationary night blindness 1H DOID:0110866 OMIM:617024
				depressive disorder IDs depressive disorder DOID:1596 DOID:14672 ICD10CM:F33.9 MESH:D003863 NCI:C2982 UMLS_CUI:C0011570
				essential hypertension IDs essential hypertension DOID:10825 ICD10CM:I10 ICD9CM:401 ICD9CM:401.9 MESH:D000075222 NCI:C3478 OMIM:145500 OMIM:603918 OMIM:604329 OMIM:607329 OMIM:608742 OMIM:610261 OMIM:610262 OMIM:610948 OMIM:611014 ORDO:243761 UMLS_CUI:C0085580
				familial hyperlipidemia IDs familial hyperlipidemia DOID:1168 DOID:3147 ICD10CM:E78.5 MESH:D006949 MESH:D006951 NCI:C34707 NCI:C34709 UMLS_CUI:C0020473 UMLS_CUI:C0020476
				hypertension IDs hypertension DOID:10763 EFO:0000537 ICD10CM:I10 ICD9CM:401-405.99 ICD9CM:997.91 MESH:D006973 NCI:C3117 UMLS_CUI:C0020538
				type 2 diabetes mellitus IDs type 2 diabetes mellitus DOID:9352 ICD10CM:E11 KEGG:04930 MESH:D003924 NCI:C26747 OMIM:125853 OMIM:601283 OMIM:601407 OMIM:603694 OMIM:608036 UMLS_CUI:C0011860

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

6 phenotypes from 1 allele in 1 genetic background
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Endonuclease-mediated

3
Targeted

4
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

23 strains or lines available

Mice homozygous for a knock-out allele exhibit abnormal light ON response and synaptic maintenance.

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All GO Annotations

30
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

769
Tissues

30
cDNA Data

24
Literature Summary

13

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase gnb3

ZFIN gnb3a, gnb3b

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All Sequences

36
RefSeq

2
UniProt

3
CCDS

CCDS20532.1

Ensembl

ENSMUSG00000023439 (Evidence)
NCBI Gene

14695

			Length	Strain/Species	Flank
genomic	14695	NCBI Gene Model \| MGI Sequence Detail	6036	C57BL/6J	± kb
transcript	NM_013530	RefSeq \| MGI Sequence Detail	1887	Not Specified
polypeptide	Q61011	UniProt \| EBI \| MGI Sequence Detail	340	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000008099 guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3

(term hierarchy)
InterPro Domains

IPR001632 G-protein, beta subunit

IPR020472 G-protein beta WD-40 repeat

IPR016346 Guanine nucleotide-binding protein, beta subunit

IPR001680 WD40 repeat

IPR019775 WD40 repeat, conserved site

IPR036322 WD40-repeat-containing domain superfamily

IPR015943 WD40/YVTN repeat-like-containing domain superfamily

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All nucleic 32

Genomic 1

cDNA 25

Primer pair 6

Microarray probesets 2

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MGD-MRK-10198, MGD-MRK-10204

Summaries

All 60

Developmental Gene Expression 13

Gene Ontology 8

Phenotypes 13
Earliest

J:10436 Danciger M, et al., The gene for the beta-subunit of retinal transducin (Gnb-1) maps to distal mouse chromosome 4, and related sequences map to mouse chromosomes 5 and 8. Genomics. 1990 Mar;6(3):428-35
Latest

J:354849 Wutikeli H, et al., Role of Elavl-like RNA-binding protein in retinal development and signal transduction. Biochim Biophys Acta Mol Basis Dis. 2024 Sep 20;1871(1):167518

TSS for Gnb3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr63187	Chr6:124817155-124817168 (-)	76 bp
Tssr63186	Chr6:124817146-124817149 (-)	90 bp
Tssr63185	Chr6:124817021-124817032 (-)	211 bp
Tssr63184	Chr6:124817004-124817015 (-)	228 bp
Tssr63183	Chr6:124816930-124816979 (-)	283 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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