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Gpi1 Gene Detail
Summary
  • Symbol
    Gpi1
  • Name
    glucose-6-phosphate isomerase 1
  • Synonyms
    AMF, autocrine motility factor, Gpi-1, Gpi1-r, Gpi-1r, Gpi1-s, Gpi-1s, Gpi1-t, Gpi-1t, maturation factor, MF, neuroleukin, NK, NK/GPI, Org
  • Feature Type
    protein coding gene
  • IDs
    MGI:95797
    NCBI Gene: 14751
  • Alliance
    gene page
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:33900755-33929761 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 19.46 cM
  • Mapping Data
    179 experiments
Strain
Comparison
more
  • SNPs within 2kb
    983 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95797
 protein coding gene Chr7:33900752-33929761 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032074
 protein coding gene Chr7:33459151-33489407 (-)
A/J MGP_AJ_G0032053
 protein coding gene Chr7:32635085-32667047 (-)
AKR/J MGP_AKRJ_G0031987
 protein coding gene Chr7:33411920-33441254 (-)
BALB/cJ MGP_BALBcJ_G0032061
 protein coding gene Chr7:32924690-32956687 (-)
C3H/HeJ MGP_C3HHeJ_G0031778
 protein coding gene Chr7:34296318-34326072 (-)
C57BL/6NJ MGP_C57BL6NJ_G0032538
 protein coding gene Chr7:35173746-35203954 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029571
 protein coding gene Chr7:33373801-33403900 (-)
CAST/EiJ MGP_CASTEiJ_G0031113
 protein coding gene Chr7:25413960-25442751 (-)
CBA/J MGP_CBAJ_G0031746
 protein coding gene Chr7:36262673-36295108 (-)
DBA/2J MGP_DBA2J_G0031898
 protein coding gene Chr7:32488328-32520329 (-)
FVB/NJ MGP_FVBNJ_G0031853
 protein coding gene Chr7:32398305-32428471 (-)
LP/J MGP_LPJ_G0031975
 protein coding gene Chr7:33831565-33861866 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0031891
 protein coding gene Chr7:35318545-35349270 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032553
 protein coding gene Chr7:32931511-32969681 (-)
PWK/PhJ MGP_PWKPhJ_G0030835
 protein coding gene Chr7:25799734-25830542 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030670
 protein coding gene Chr7:22502123-22535946 (-)
WSB/EiJ MGP_WSBEiJ_G0031223
 protein coding gene Chr7:33474776-33504036 (-)



Homology
more
  • Human Ortholog
    GPI, glucose-6-phosphate isomerase
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GPI, glucose-6-phosphate isomerase
  • Synonyms
    AMF, CNSHA4, GNPI, NLK, PGI, PHI, SA-36, SA36
  • Links
    NCBI Gene ID: 2821
    neXtProt AC: NX_P06744
    UniProt: P06744

  • Chr Location
    19q13.11; chr19:34359480-34402413 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Gpi1 mouse models; 4 with human GPI associations

Human Disease Mouse Models
      
IDs
 View 2 models
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    25 phenotypes from 9 alleles in 7 genetic backgrounds
    45 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for null mutations fail to develop beyond the egg cylinder stage and die by embryonic day 9.5. Homozygotes for a hypomorphic mutation exhibit nonspherocytic hemolytic anemia with hepatosplenomegaly.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    53
  • GO References
    29
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    909
  • Tissues
    169
  • cDNA Data
    477
  • Literature Summary
    9
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000036427 Ensembl Gene Model | MGI Sequence Detail 29007 C57BL/6J ±  kb
    transcript ENSMUST00000038027 Ensembl | MGI Sequence Detail 2884 Not Applicable  
    polypeptide ENSMUSP00000049355 Ensembl | MGI Sequence Detail 558 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 483
      cDNA 479
      Primer pair 3
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-10227, MGD-MRK-10228, MGD-MRK-10229, MGD-MRK-10230, MGD-MRK-10231, MGD-MRK-10232, MGD-MRK-10233, MGD-MRK-10234, MGD-MRK-13047, MGI:95798, MGI:95799, MGI:95800
    References
    more
    • Summaries
      All 256
      Developmental Gene Expression 9
      Diseases 1
      Gene Ontology 29
      Phenotypes 45
    • Earliest
      J:5134 Hutton JJ, Linkage analyses using biochemical variants in mice. I. Linkage of the hemoglobin beta-chain and glucosephosphate isomerase loci. Biochem Genet. 1969 Oct;3(5):507-15
    • Latest
      J:337927 Kawakami H, et al., Sall4 restricts glycolytic metabolism in limb buds through transcriptional regulation of glycolytic enzyme genes. Dev Biol. 2023 Sep;501:28-38
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory