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Gria2 Gene Detail
Summary
  • Symbol
    Gria2
  • Name
    glutamate receptor, ionotropic, AMPA2 (alpha 2)
  • Synonyms
    GluA2, Glur-2, Glur2, GluR2, GluR-B
  • Feature Type
    protein coding gene
  • IDs
    MGI:95809
    NCBI Gene: 14800
  • Alliance
    gene page
  • Transcription Start Sites
    17 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:80588757-80710142 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 35.50 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3400 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95809
 protein coding gene Chr3:80588757-80711534 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027319
 protein coding gene Chr3:80437104-80560161 (-)
A/J MGP_AJ_G0027281
 protein coding gene Chr3:77779219-77895500 (-)
AKR/J MGP_AKRJ_G0027249
 protein coding gene Chr3:79580985-79705608 (-)
BALB/cJ MGP_BALBcJ_G0027292
 protein coding gene Chr3:77841429-77962358 (-)
C3H/HeJ MGP_C3HHeJ_G0027036
 protein coding gene Chr3:79918083-80041982 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027738
 protein coding gene Chr3:83500410-83631888 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025091
 protein coding gene Chr3:73603768-73722255 (-)
CAST/EiJ MGP_CASTEiJ_G0026483
 protein coding gene Chr3:80018049-80146468 (-)
CBA/J MGP_CBAJ_G0027011
 protein coding gene Chr3:86265256-86399223 (-)
DBA/2J MGP_DBA2J_G0027147
 protein coding gene Chr3:77328468-77445608 (-)
FVB/NJ MGP_FVBNJ_G0027115
 protein coding gene Chr3:75664150-75781521 (-)
LP/J MGP_LPJ_G0027255
 protein coding gene Chr3:81423845-81550827 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027134
 protein coding gene Chr3:92564923-92709190 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027796
 protein coding gene Chr3:79413740-79538797 (-)
PWK/PhJ MGP_PWKPhJ_G0026217
 protein coding gene Chr3:77078510-77197634 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026033
 protein coding gene Chr3:78599386-78728956 (-)
WSB/EiJ MGP_WSBEiJ_G0026561
 protein coding gene Chr3:79752099-79876199 (-)



Homology
more
  • Human Ortholog
    GRIA2, glutamate ionotropic receptor AMPA type subunit 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GRIA2, glutamate ionotropic receptor AMPA type subunit 2
  • Synonyms
    GluA2, gluR-2, GLUR2, gluR-B, GLURB, GluR-K2, HBGR2, NEDLIB
  • Links
    NCBI Gene ID: 2891
    neXtProt AC: NX_P42262
    UniProt: P42262

  • Chr Location
    4q32.1; chr4:157204182-157387146 (+)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    76 phenotypes from 15 alleles in 17 genetic backgrounds
    20 phenotypes from multigenic genotypes
    116 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit epilepsy, deficient dendritic architecture, altered exploratory behavior, impaired motor and learning performance, and increased mortality.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    114
  • GO References
    31
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    942
  • Tissues
    106
  • cDNA Data
    21
  • Literature Summary
    68
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000033981 Ensembl Gene Model | MGI Sequence Detail 121386 C57BL/6J ±  kb
    transcript ENSMUST00000075316 Ensembl | MGI Sequence Detail 10371 Not Applicable  
    polypeptide ENSMUSP00000074787 Ensembl | MGI Sequence Detail 883 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      9 Sequences
    • Protein Ontology
      PR:000008234 glutamate receptor 2
      (term hierarchy)
    • PDB
      7LDD, 7LDE, 7LEP
    • InterPro Domains
      IPR015683 Ionotropic glutamate receptor
      IPR001320 Ionotropic glutamate receptor, C-terminal
      IPR019594 Ionotropic glutamate receptor, L-glutamate and glycine-binding domain
      IPR001508 Ionotropic glutamate receptor, metazoa
      IPR028082 Periplasmic binding protein-like I
      IPR001828 Receptor, ligand binding region
    • GlyGen
      P23819 5 sites, 13 N-linked glycans (4 sites), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 34
      Genomic 6
      cDNA 24
      Primer pair 3
      Other 1

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGD-MRK-10141, MGD-MRK-10148, MGD-MRK-10247
    References
    more
    • Summaries
      All 308
      Developmental Gene Expression 68
      Diseases 1
      Gene Ontology 31
      Phenotypes 116
    • Earliest
      J:10801 Sakimura K, et al., Functional expression from cloned cDNAs of glutamate receptor species responsive to kainate and quisqualate. FEBS Lett. 1990 Oct 15;272(1-2):73-80
    • Latest
      J:353307 Ratsika A, et al., Maternal high-fat diet-induced microbiota changes are associated with alterations in embryonic brain metabolites and adolescent behaviour. Brain Behav Immun. 2024 Jul 18;121:317-330
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory