Grid1 MGI Mouse Gene Detail - MGI:95812 - glutamate receptor, ionotropic, delta 1

Symbol

Grid1
Name

glutamate receptor, ionotropic, delta 1
Synonyms

GluRdelta1

Feature Type

protein coding gene
IDs

MGI:95812
NCBI Gene: 14803
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr14:34542065-35305336 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 14, 20.84 cM
Mapping Data

3 experiments

SNPs within 2kb

19444 from dbSNP Build 142
Strain Annotations

18
PCR

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_95812	protein coding gene	Chr14:34541751-35305344 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0021180	protein coding gene	Chr14:28183246-28966683 (+)
A/J	MGP_AJ_G0021128	protein coding gene	Chr14:27106304-27846393 (+)
AKR/J	MGP_AKRJ_G0021105	protein coding gene	Chr14:28293547-29088327 (+)
BALB/cJ	MGP_BALBcJ_G0021132	protein coding gene	Chr14:27282863-28041880 (+)
C3H/HeJ	MGP_C3HHeJ_G0020915	protein coding gene	Chr14:28244955-29020169 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0021564	protein coding gene	Chr14:29269996-30096284 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019126	protein coding gene	Chr14:27101351-27837195 (+)
CAST/EiJ	MGP_CASTEiJ_G0020440	protein coding gene	Chr14:28034721-28835082 (+)
CBA/J	MGP_CBAJ_G0020881	protein coding gene	Chr14:30334505-31181822 (+)
DBA/2J	MGP_DBA2J_G0021004	protein coding gene	Chr14:27122955-27874877 (+)
FVB/NJ	MGP_FVBNJ_G0020988	protein coding gene	Chr14:27103127-27866688 (+)
LP/J	MGP_LPJ_G0021073	protein coding gene	Chr14:28513534-29298393 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021014	protein coding gene	Chr14:29477337-30296409 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021597	protein coding gene	Chr14:28144597-28938171 (+)
PWK/PhJ	MGP_PWKPhJ_G0020188	protein coding gene	Chr14:26619173-27358627 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0020012	protein coding gene	Chr14:27736246-28516922 (+)
WSB/EiJ	MGP_WSBEiJ_G0020495	protein coding gene	Chr14:28192538-28973534 (+)

Human Ortholog

GRID1, glutamate ionotropic receptor delta type subunit 1

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

GRID1, glutamate ionotropic receptor delta type subunit 1
Synonyms

GluD1, GluD1-b
Links

HGNC:4575

NCBI Gene ID: 2894

neXtProt AC: NX_Q9ULK0

UniProt: Q9ULK0
Chr Location

10q23.1-q23.2; chr10:85599552-86366795 (-) GRCh38

MGI Vertebrate Homology

Grid1 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: GRID1
Gene Tree

Grid1

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Phenotype Summary

12 phenotypes from 2 alleles in 2 genetic backgrounds
15 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Endonuclease-mediated

4
Targeted

2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

59 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygotes for a targeted null mutation display a significant high-frequency hearing loss, associated with reductions of both cochlear outer hair cell function and endolymphatic potential, as well as increased vulnerability to acoustic injury.

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All GO Annotations

32
GO References

12

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

946
Tissues

84
cDNA Data

9
Literature Summary

6

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase grid1

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All Sequences

39
RefSeq

8
UniProt

1
CCDS

CCDS26944.1

Ensembl

ENSMUSG00000041078 (Evidence)
NCBI Gene

14803

			Length	Strain/Species	Flank
genomic	ENSMUSG00000041078	Ensembl Gene Model \| MGI Sequence Detail	763272	C57BL/6J	± kb
transcript	ENSMUST00000043349	Ensembl \| MGI Sequence Detail	5720	Not Applicable
polypeptide	ENSMUSP00000044009	Ensembl \| MGI Sequence Detail	1009	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000008237 glutamate receptor ionotropic, delta-1

(term hierarchy)
PDB

5KC9
InterPro Domains

IPR015683 Ionotropic glutamate receptor

IPR001320 Ionotropic glutamate receptor, C-terminal

IPR019594 Ionotropic glutamate receptor, L-glutamate and glycine-binding domain

IPR001508 Ionotropic glutamate receptor, metazoa

IPR028082 Periplasmic binding protein-like I

IPR001828 Receptor, ligand binding region
GlyGen

Q61627 7 sites, 5 N-linked glycans (3 sites), 1 O-linked glycan (3 sites)

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All nucleic 13

cDNA 9

Primer pair 3

Other 1

Microarray probesets 4

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MGD-MRK-10250

Summaries

All 52

Developmental Gene Expression 6

Gene Ontology 12

Phenotypes 15
Earliest

J:320 Yamazaki M, et al., Molecular cloning of a cDNA encoding a novel member of the mouse glutamate receptor channel family. Biochem Biophys Res Commun. 1992 Mar 16;183(2):886-92
Latest

J:331142 Han P, et al., Cbln1 regulates axon growth and guidance in multiple neural regions. PLoS Biol. 2022 Nov;20(11):e3001853

TSS for Grid1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr125099	Chr14:34541768-34541791 (+)	-285 bp
Tssr125100	Chr14:34541797-34541813 (+)	-260 bp
Tssr125101	Chr14:34542052-34542110 (+)	16 bp
Tssr125102	Chr14:34779134-34779137 (+)	237,071 bp
Tssr4372	Chr14:34819392-34819393 (+)	277,328 bp
Tssr125103	Chr14:34969377-34969384 (+)	427,316 bp
Tssr125104	Chr14:35302795-35302831 (+)	760,748 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24