Grik3 MGI Mouse Gene Detail - MGI:95816 - glutamate receptor, ionotropic, kainate 3

Symbol

Grik3
Name

glutamate receptor, ionotropic, kainate 3
Synonyms

Glur-7, Glur7

Feature Type

protein coding gene
IDs

MGI:95816
NCBI Gene: 14807
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr4:125384493-125607966 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 58.91 cM
Mapping Data

4 experiments

SNPs within 2kb

6888 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_95816	protein coding gene	Chr4:125384025-125607966 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0028766	protein coding gene	Chr4:127097131-127323691 (+)
A/J	MGP_AJ_G0028725	protein coding gene	Chr4:122099176-122321340 (+)
AKR/J	MGP_AKRJ_G0028678	protein coding gene	Chr4:125452841-125682956 (+)
BALB/cJ	MGP_BALBcJ_G0028748	protein coding gene	Chr4:122690793-122909237 (+)
C3H/HeJ	MGP_C3HHeJ_G0028462	protein coding gene	Chr4:125523414-125747162 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0029190	protein coding gene	Chr4:131978708-132218524 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0026463	protein coding gene	Chr4:115263796-115483331 (+)
CAST/EiJ	MGP_CASTEiJ_G0027895	protein coding gene	Chr4:123616678-123846928 (+)
CBA/J	MGP_CBAJ_G0028428	protein coding gene	Chr4:135237955-135462346 (+)
DBA/2J	MGP_DBA2J_G0028577	protein coding gene	Chr4:122572365-122793243 (+)
FVB/NJ	MGP_FVBNJ_G0028544	protein coding gene	Chr4:121207820-121429220 (+)
LP/J	MGP_LPJ_G0028678	protein coding gene	Chr4:127385510-127613993 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0028570	protein coding gene	Chr4:140223648-140447079 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0029228	protein coding gene	Chr4:125803226-126033814 (+)
PWK/PhJ	MGP_PWKPhJ_G0027616	protein coding gene	Chr4:119015165-119238946 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0027442	protein coding gene	Chr4:121600930-121831258 (+)
WSB/EiJ	MGP_WSBEiJ_G0027975	protein coding gene	Chr4:125897726-126126272 (+)

Human Ortholog

GRIK3, glutamate ionotropic receptor kainate type subunit 3

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

GRIK3, glutamate ionotropic receptor kainate type subunit 3
Synonyms

EAA5, GLR7, GluK3, GLUR7, GluR7a
Links

HGNC:4581

NCBI Gene ID: 2899

neXtProt AC: NX_Q13003

UniProt: Q13003
Chr Location

1p34.3; chr1:36795527-37034515 (-) GRCh38

MGI Vertebrate Homology

Grik3 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: GRIK3
Gene Tree

Grik3

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Phenotype Summary

16 phenotypes from 2 alleles in 2 genetic backgrounds
23 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

78
Chemically induced (other)

2
Endonuclease-mediated

3
Gene trapped

67
Radiation induced

1
Targeted

5
Genomic Mutations

4 involving Grik3
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

83 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit significantly reduced short- and long-term synaptic potentiation.

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All GO Annotations

47
GO References

12

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

769
Tissues

43
cDNA Data

19
Literature Summary

13

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase grik3

ZFIN grik3

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All Sequences

46
RefSeq

8
UniProt

1
CCDS

CCDS38878.1

Ensembl

ENSMUSG00000001985 (Evidence)
NCBI Gene

14807

			Length	Strain/Species	Flank
genomic	ENSMUSG00000001985	Ensembl Gene Model \| MGI Sequence Detail	223474	C57BL/6J	± kb
transcript	ENSMUST00000030676	Ensembl \| MGI Sequence Detail	8973	Not Applicable
polypeptide	ENSMUSP00000030676	Ensembl \| MGI Sequence Detail	919	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000008242 glutamate receptor ionotropic, kainate 3

(term hierarchy)
InterPro Domains

IPR015683 Ionotropic glutamate receptor

IPR001320 Ionotropic glutamate receptor, C-terminal

IPR019594 Ionotropic glutamate receptor, L-glutamate and glycine-binding domain

IPR001508 Ionotropic glutamate receptor, metazoa

IPR028082 Periplasmic binding protein-like I

IPR001828 Receptor, ligand binding region
GlyGen

B1AS29 12 sites, 12 N-linked glycans (7 sites), 1 O-linked glycan (2 sites)

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All nucleic 25

cDNA 20

Primer pair 3

Other 2

Microarray probesets 3

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MGD-MRK-10146, MGD-MRK-10153, MGD-MRK-10254

Summaries

All 78

Developmental Gene Expression 13

Gene Ontology 12

Phenotypes 23
Earliest

J:696 Sakimura K, et al., Primary structure and expression of the gamma 2 subunit of the glutamate receptor channel selective for kainate. Neuron. 1992 Feb;8(2):267-74
Latest

J:353307 Ratsika A, et al., Maternal high-fat diet-induced microbiota changes are associated with alterations in embryonic brain metabolites and adolescent behaviour. Brain Behav Immun. 2024 Jul 18;121:317-330

TSS for Grik3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr38946	Chr4:125384201-125384249 (+)	-268 bp
Tssr38947	Chr4:125384261-125384286 (+)	-219 bp
Tssr38948	Chr4:125384481-125384497 (+)	-4 bp
Tssr38951	Chr4:125501423-125501426 (+)	116,932 bp
Tssr38952	Chr4:125503739-125503755 (+)	119,254 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24