About   Help   FAQ
Grik4 Gene Detail
Summary
  • Symbol
    Grik4
  • Name
    glutamate receptor, ionotropic, kainate 4
  • Synonyms
    6330551K01Rik, GluRgamma1, KA-1, KA1
  • Feature Type
    protein coding gene
  • IDs
    MGI:95817
    NCBI Gene: 110637
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:42431708-42856296 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 23.80 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    12134 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95817
 protein coding gene Chr9:42429431-42856296 (-)
129S1/SvImJ MGP_129S1SvImJ_G0034679
 protein coding gene Chr9:40865621-41315486 (-)
A/J MGP_AJ_G0034659
 protein coding gene Chr9:39780529-40213477 (-)
AKR/J MGP_AKRJ_G0034585
 protein coding gene Chr9:40553902-40992570 (-)
BALB/cJ MGP_BALBcJ_G0034650
 protein coding gene Chr9:39510834-39941570 (-)
C3H/HeJ MGP_C3HHeJ_G0034361
 protein coding gene Chr9:41047241-41488190 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035173
 protein coding gene Chr9:42134244-42579055 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032086
 protein coding gene Chr9:39397809-39825694 (-)
CAST/EiJ MGP_CASTEiJ_G0033684
 protein coding gene Chr9:40854107-41291160 (-)
CBA/J MGP_CBAJ_G0034334
 protein coding gene Chr9:43622603-44083324 (-)
DBA/2J MGP_DBA2J_G0034493
 protein coding gene Chr9:39699908-40130217 (-)
FVB/NJ MGP_FVBNJ_G0034433
 protein coding gene Chr9:38928267-39364652 (-)
LP/J MGP_LPJ_G0034574
 protein coding gene Chr9:41149591-41602555 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034477
 protein coding gene Chr9:45586456-46039757 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035192
 protein coding gene Chr9:40460902-40902473 (-)
PWK/PhJ MGP_PWKPhJ_G0033389
 protein coding gene Chr9:39531548-39968989 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033225
 protein coding gene Chr9:40727594-41189546 (-)
WSB/EiJ MGP_WSBEiJ_G0033797
 protein coding gene Chr9:40502311-40955727 (-)



Homology
more
  • Human Ortholog
    GRIK4, glutamate ionotropic receptor kainate type subunit 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GRIK4, glutamate ionotropic receptor kainate type subunit 4
  • Synonyms
    EAA1, GluK4, GluK4-2, GRIK, KA1
  • Links
    NCBI Gene ID: 2900
    neXtProt AC: NX_Q16099
    UniProt: Q16099

  • Chr Location
    11q23.3; chr11:120511746-120988906 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 3 alleles in 3 genetic backgrounds
    13 phenotypes from multigenic genotypes
    1 images
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit reduced GYKI-resistant excitatory postsynaptic current.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    30
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    774
  • Tissues
    46
  • cDNA Data
    6
  • Literature Summary
    30
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 110637 NCBI Gene Model | MGI Sequence Detail 424589 C57BL/6J ±  kb
    transcript NM_175481 RefSeq | MGI Sequence Detail 5899 C57BL/6  
    polypeptide Q8BMF5 UniProt | EBI | MGI Sequence Detail 956 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000008243 glutamate receptor ionotropic, kainate 4
      (term hierarchy)
    • InterPro Domains
      IPR015683 Ionotropic glutamate receptor
      IPR001320 Ionotropic glutamate receptor, C-terminal
      IPR019594 Ionotropic glutamate receptor, L-glutamate and glycine-binding domain
      IPR001508 Ionotropic glutamate receptor, metazoa
      IPR028082 Periplasmic binding protein-like I
      IPR001828 Receptor, ligand binding region
    • GlyGen
      Q8BMF5 9 sites, 2 N-linked glycans (2 sites)
    Molecular
    Reagents
    less
    • All nucleic 15
      Genomic 2
      cDNA 9
      Primer pair 2
      Other 2

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGD-MRK-10255, MGI:2445129
    References
    more
    • Summaries
      All 86
      Developmental Gene Expression 30
      Gene Ontology 9
      Phenotypes 22
    • Earliest
      J:21927 Szpirer C, et al., The genes encoding the glutamate receptor subunits KA1 and KA2 (GRIK4 and GRIK5) are located on separate chromosomes in human, mouse, and rat. Proc Natl Acad Sci U S A. 1994 Dec 6;91(25):11849-53
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory