Grp MGI Mouse Gene Detail - MGI:95833 - gastrin releasing peptide

Symbol

Grp
Name

gastrin releasing peptide
Synonyms

BLP, MGC:37475

Feature Type

protein coding gene
IDs

MGI:95833
NCBI Gene: 225642
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr18:66005891-66019667 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 18, 38.98 cM
Mapping Data

2 experiments

SNPs within 2kb

547 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_95833	protein coding gene	Chr18:66005826-66019670 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0024512	protein coding gene	Chr18:66034359-66050083 (+)
A/J	MGP_AJ_G0024479	protein coding gene	Chr18:63164651-63178824 (+)
AKR/J	MGP_AKRJ_G0024449	protein coding gene	Chr18:64951870-64965516 (+)
BALB/cJ	MGP_BALBcJ_G0024478	protein coding gene	Chr18:63306094-63321305 (+)
C3H/HeJ	MGP_C3HHeJ_G0024246	protein coding gene	Chr18:65156897-65172449 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0024925	protein coding gene	Chr18:67790026-67803707 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022356	protein coding gene	Chr18:62611333-62625409 (+)
CAST/EiJ	MGP_CASTEiJ_G0023719	protein coding gene	Chr18:65159052-65174247 (+)
CBA/J	MGP_CBAJ_G0024216	protein coding gene	Chr18:70042008-70056084 (+)
DBA/2J	MGP_DBA2J_G0024346	protein coding gene	Chr18:62833222-62847138 (+)
FVB/NJ	MGP_FVBNJ_G0024312	protein coding gene	Chr18:62215894-62229693 (+)
LP/J	MGP_LPJ_G0024430	protein coding gene	Chr18:65888774-65906222 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024341	protein coding gene	Chr18:71430209-71444981 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0024972	protein coding gene	Chr18:65156123-65172222 (+)
PWK/PhJ	MGP_PWKPhJ_G0023462	protein coding gene	Chr18:63083871-63097836 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0023267	protein coding gene	Chr18:65320377-65334005 (+)
WSB/EiJ	MGP_WSBEiJ_G0023783	protein coding gene	Chr18:65020213-65036595 (+)

Human Ortholog

GRP, gastrin releasing peptide

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

GRP, gastrin releasing peptide
Synonyms

BN, GRP-10, preproGRP, proGRP
Links

HGNC:4605

NCBI Gene ID: 2922

neXtProt AC: NX_P07492

UniProt: P07492
Chr Location

18q21.32; chr18:59219189-59230774 (+) GRCh38

MGI Vertebrate Homology

Grp stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: GRP
Gene Tree

Grp

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Phenotype Summary

4 phenotypes from 2 alleles in 2 genetic backgrounds
3 phenotypes from multigenic genotypes
19 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

19
Endonuclease-mediated

6
Gene trapped

7
Targeted

6
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

30 strains or lines available
Comparison Matrix

Gene Expression + Phenotype
Recombinase Activity

Comparison Matrix Gene Expression + Recombinase Activity

Mice homozygous for a knock-out allele exhibit attenuated scratching response to chloroquine, SLIGRL and BAM8-22.

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All GO Annotations

31
GO References

11

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

871
Tissues

129
cDNA Data

8
Literature Summary

22

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase grp

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All Sequences

39
RefSeq

6
UniProt

1
CCDS

CCDS29310.1

Ensembl

ENSMUSG00000024517 (Evidence)
NCBI Gene

225642

			Length	Strain/Species	Flank
genomic	ENSMUSG00000024517	Ensembl Gene Model \| MGI Sequence Detail	13777	C57BL/6J	± kb
transcript	ENSMUST00000173985	Ensembl \| MGI Sequence Detail	969	Not Applicable
polypeptide	ENSMUSP00000133437	Ensembl \| MGI Sequence Detail	146	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000031729 gastrin-releasing peptide

(term hierarchy)
InterPro Domains

IPR000874 Bombesin/neuromedin-B/ranatensin peptide family

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All nucleic 13

cDNA 9

Primer pair 3

Other 1

Microarray probesets 3

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MGD-MRK-10273

Summaries

All 78

Developmental Gene Expression 22

Gene Ontology 11

Phenotypes 19
Earliest

J:15302 Spindel ER, et al., Cloning and characterization of cDNAs encoding human gastrin-releasing peptide. Proc Natl Acad Sci U S A. 1984 Sep;81(18):5699-703
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Grp:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr151704	Chr18:66006549-66006566 (+)	667 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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