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Grpr Gene Detail
Summary
  • Symbol
    Grpr
  • Name
    gastrin releasing peptide receptor
  • Synonyms
    bombesin receptor, GRP-R
  • Feature Type
    protein coding gene
  • IDs
    MGI:95836
    NCBI Gene: 14829
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    ChrX:162296900-162332673 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 75.63 cM
  • Mapping Data
    27 experiments
Strain
Comparison
more
  • SNPs within 2kb
    745 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    3
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95836
 protein coding gene ChrX:162296900-162332732 (-)
129S1/SvImJ MGP_129S1SvImJ_G0036245
 protein coding gene ChrX:161562497-161604012 (-)
A/J MGP_AJ_G0036215
 protein coding gene ChrX:160746166-160783294 (-)
AKR/J MGP_AKRJ_G0036143
 protein coding gene ChrX:165910776-165947488 (-)
BALB/cJ MGP_BALBcJ_G0036208
 protein coding gene ChrX:158757349-158793869 (-)
C3H/HeJ MGP_C3HHeJ_G0035914
 protein coding gene ChrX:161925669-161964965 (-)
C57BL/6NJ MGP_C57BL6NJ_G0036730
 protein coding gene ChrX:166317096-166356453 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0033552
 protein coding gene ChrX:151824695-151860440 (-)
CAST/EiJ MGP_CASTEiJ_G0035203
 protein coding gene ChrX:140896794-140936222 (-)
CBA/J MGP_CBAJ_G0035889
 protein coding gene ChrX:171126549-171170859 (-)
DBA/2J MGP_DBA2J_G0036055
 protein coding gene ChrX:159651229-159687602 (-)
FVB/NJ MGP_FVBNJ_G0035986
 protein coding gene ChrX:158788922-158824882 (-)
LP/J MGP_LPJ_G0036140
 protein coding gene ChrX:162734958-162771372 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0036018
 protein coding gene ChrX:179794561-179836989 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0036771
 protein coding gene ChrX:161057881-161094376 (-)
PWK/PhJ MGP_PWKPhJ_G0034901
 protein coding gene ChrX:137694039-137733616 (-)
SPRET/EiJ MGP_SPRETEiJ_G0034722
 protein coding gene ChrX:141378625-141418383 (-)
WSB/EiJ MGP_WSBEiJ_G0035338
 protein coding gene ChrX:159024866-159063502 (-)



Homology
more
  • Human Ortholog
    GRPR, gastrin releasing peptide receptor
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GRPR, gastrin releasing peptide receptor
  • Synonyms
    BB2, BB2R, BRS2
  • Links
    NCBI Gene ID: 2925
    neXtProt AC: NX_P30550
    UniProt: P30550

  • Chr Location
    Xp22.2; chrX:16123565-16153518 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 2 alleles in 2 genetic backgrounds
    2 phenotypes from multigenic genotypes
    55 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Male mice hemizygous for a knock-out allele lack bombesin-induced satiety response. Male mice hemizygous for another knock-out allele exhibit hyperactivity, abnormal social investigation, and insensitivity to gastrin-releasing peptide-induced hypothermia.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    27
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    740
  • Tissues
    19
  • cDNA Data
    8
  • Literature Summary
    10
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000031364 Ensembl Gene Model | MGI Sequence Detail 35774 C57BL/6J ±  kb
transcript ENSMUST00000033730 Ensembl | MGI Sequence Detail 2523 Not Applicable  
polypeptide ENSMUSP00000033730 Ensembl | MGI Sequence Detail 384 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 14
    cDNA 8
    Primer pair 3
    Other 3

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-10276
References
more
  • Summaries
    All 115
    Developmental Gene Expression 10
    Gene Ontology 12
    Phenotypes 55
  • Earliest
    J:11093 Spindel ER, et al., Cloning and functional characterization of a complementary DNA encoding the murine fibroblast bombesin/gastrin-releasing peptide receptor. Mol Endocrinol. 1990 Dec;4(12):1956-63
  • Latest
    J:348363 Matsumoto Y, et al., Slitrk4 is required for the development of inhibitory neurons in the fear memory circuit of the lateral amygdala. Front Mol Neurosci. 2024;17:1386924
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory