Gsx1 MGI Mouse Gene Detail - MGI:95842

Symbol

Gsx1
Name

GS homeobox 1
Synonyms

Gsh-1, Gsh1

Feature Type

protein coding gene
IDs

MGI:95842
NCBI Gene: 14842
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr5:147125506-147127757 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 86.79 cM
Mapping Data

3 experiments

SNPs within 2kb

116 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_95842	protein coding gene	Chr5:147125492-147127757 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0030385	protein coding gene	Chr5:152826961-152829197 (+)
A/J	MGP_AJ_G0030358	protein coding gene	Chr5:146356406-146359159 (+)
AKR/J	MGP_AKRJ_G0030285	protein coding gene	Chr5:150854486-150856729 (+)
BALB/cJ	MGP_BALBcJ_G0030367	protein coding gene	Chr5:147568791-147571038 (+)
C3H/HeJ	MGP_C3HHeJ_G0030081	protein coding gene	Chr5:151820353-151822605 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0030822	protein coding gene	Chr5:158420828-158425531 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0028035	protein coding gene	Chr5:140774020-140776296 (+)
CAST/EiJ	MGP_CASTEiJ_G0029483	protein coding gene	Chr5:151373198-151375474 (+)
CBA/J	MGP_CBAJ_G0030059	protein coding gene	Chr5:165030434-165033485 (+)
DBA/2J	MGP_DBA2J_G0030203	protein coding gene	Chr5:146035642-146039481 (+)
FVB/NJ	MGP_FVBNJ_G0030157	protein coding gene	Chr5:145235578-145238260 (+)
LP/J	MGP_LPJ_G0030290	protein coding gene	Chr5:153529475-153531580 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0030193	protein coding gene	Chr5:167320233-167322492 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0030852	protein coding gene	Chr5:150755183-150758371 (+)
PWK/PhJ	MGP_PWKPhJ_G0029197	protein coding gene	Chr5:145119392-145121993 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0029033	protein coding gene	Chr5:148083509-148085847 (+)
WSB/EiJ	MGP_WSBEiJ_G0029560	protein coding gene	Chr5:151550057-151554548 (+)

Human Ortholog

GSX1, GS homeobox 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

GSX1, GS homeobox 1
Synonyms

Gsh-1, GSH1
Links

HGNC:20374

NCBI Gene ID: 219409

neXtProt AC: NX_Q9H4S2

UniProt: Q9H4S2
Chr Location

13q12.2; chr13:27792483-27794768 (+) GRCh38

MGI Vertebrate Homology

Gsx1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: GSX1
Gene Tree

Gsx1

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Phenotype Summary

23 phenotypes from 1 allele in 1 genetic background
2 phenotypes from multigenic genotypes
20 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Endonuclease-mediated

2
Gene trapped

1
Targeted

4
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

11 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele show partial neonatal and peri-weaning lethality, delayed eyelid opening, dwarfism, multiple hormone deficiencies, aberrant pituitary development, hypothalamic dysfunction, altered bone epiphyseal growth plates, low WBC counts, infertility and premature death.

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All GO Annotations

23
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1041
Tissues

240
cDNA Data

7
Literature Summary

52

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase gsx1

ZFIN gsx1

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All Sequences

29
RefSeq

2
UniProt

2
CCDS

CCDS19877.1

Ensembl

ENSMUSG00000053129 (Evidence)
NCBI Gene

14842

			Length	Strain/Species	Flank
genomic	ENSMUSG00000053129	Ensembl Gene Model \| MGI Sequence Detail	2252	C57BL/6J	± kb
transcript	ENSMUST00000065382	Ensembl \| MGI Sequence Detail	1773	Not Applicable
polypeptide	ENSMUSP00000069728	Ensembl \| MGI Sequence Detail	261	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000008308 GS homeobox 1

(term hierarchy)
InterPro Domains

IPR042191 GS homeobox 1/2

IPR017970 Homeobox, conserved site

IPR001356 Homeobox domain

IPR020479 Homeobox domain, metazoa

IPR009057 Homeobox-like domain superfamily

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All nucleic 19

Genomic 1

cDNA 9

Primer pair 3

Other 6

Microarray probesets 3

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MGD-MRK-10284, MGD-MRK-10289

Summaries

All 85

Developmental Gene Expression 52

Gene Ontology 7

Phenotypes 20
Earliest

J:1775 Singh G, et al., Identification of 10 murine homeobox genes. Proc Natl Acad Sci U S A. 1991 Dec 1;88(23):10706-10
Latest

J:340405 Talley MJ, et al., Distinct requirements for Tcf3 and Tcf12 during oligodendrocyte development in the mouse telencephalon. Neural Dev. 2023 Sep 8;18(1):5

TSS for Gsx1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr49806	Chr5:147125488-147125494 (+)	-15 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24