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Gsn Gene Detail
Summary
  • Symbol
    Gsn
  • Name
    gelsolin
  • Feature Type
    protein coding gene
  • IDs
    MGI:95851
    NCBI Gene: 227753
  • Alliance
    gene page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:35146392-35197904 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 23.50 cM
  • Mapping Data
    12 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1362 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    3
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95851
 protein coding gene Chr2:35146371-35197914 (+)
129S1/SvImJ MGP_129S1SvImJ_G0025651
 protein coding gene Chr2:33886862-33939440 (+)
A/J MGP_AJ_G0025628
 protein coding gene Chr2:32451709-32503202 (+)
AKR/J MGP_AKRJ_G0025598
 protein coding gene Chr2:33593690-33645182 (+)
BALB/cJ MGP_BALBcJ_G0025625
 protein coding gene Chr2:32560447-32611973 (+)
C3H/HeJ MGP_C3HHeJ_G0025385
 protein coding gene Chr2:33485900-33537383 (+)
C57BL/6NJ MGP_C57BL6NJ_G0026069
 protein coding gene Chr2:34862975-34916691 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023478
 protein coding gene Chr2:31134631-31186679 (+)
CAST/EiJ MGP_CASTEiJ_G0024847
 protein coding gene Chr2:33477724-33529209 (+)
CBA/J MGP_CBAJ_G0025363
 protein coding gene Chr2:36207721-36260598 (+)
DBA/2J MGP_DBA2J_G0025496
 protein coding gene Chr2:32216653-32267961 (+)
FVB/NJ MGP_FVBNJ_G0025458
 protein coding gene Chr2:32113664-32165157 (+)
LP/J MGP_LPJ_G0025582
 protein coding gene Chr2:33814800-33866116 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0025489
 protein coding gene Chr2:35716246-35767569 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0026127
 protein coding gene Chr2:33479584-33531007 (+)
PWK/PhJ MGP_PWKPhJ_G0024595
 protein coding gene Chr2:32130223-32182377 (+)
SPRET/EiJ MGP_SPRETEiJ_G0024395
 protein coding gene Chr2:33644264-33698101 (+)
WSB/EiJ MGP_WSBEiJ_G0024916
 protein coding gene Chr2:33662529-33713897 (+)



Homology
more
  • Human Ortholog
    GSN, gelsolin
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GSN, gelsolin
  • Synonyms
    ADF, AGEL, AMYLD4
  • Links
    NCBI Gene ID: 2934
    neXtProt AC: NX_P06396
    UniProt: P06396

  • Chr Location
    9q33.2; chr9:121201483-121332843 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human GSN associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    28 phenotypes from 1 allele in 3 genetic backgrounds
    2 phenotypes from multigenic genotypes
    37 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene display abnormalities in the immune system, platelet and platelet function, bone density, nervous and circulatory system. In addition, there are background related effects on viability and mammary gland development.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    106
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    983
  • Tissues
    223
  • cDNA Data
    356
  • Literature Summary
    23
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000026879 Ensembl Gene Model | MGI Sequence Detail 51513 C57BL/6J ±  kb
    transcript ENSMUST00000028239 Ensembl | MGI Sequence Detail 2653 Not Applicable  
    polypeptide ENSMUSP00000028239 Ensembl | MGI Sequence Detail 780 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 365
      cDNA 357
      Primer pair 7
      Other 1

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGD-MRK-10302
    References
    more
    • Summaries
      All 113
      Developmental Gene Expression 23
      Gene Ontology 14
      Phenotypes 37
    • Earliest
      J:9903 Dieffenbach CW, et al., Cloning of murine gelsolin and its regulation during differentiation of embryonal carcinoma cells. J Biol Chem. 1989 Aug 5;264(22):13281-8
    • Latest
      J:347151 Kuwabara Y, et al., A human FLII gene variant alters sarcomeric actin thin filament length and predisposes to cardiomyopathy. Proc Natl Acad Sci U S A. 2023 May 9;120(19):e2213696120
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory