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Gstp1 Gene Detail
Summary
  • Symbol
    Gstp1
  • Name
    glutathione S-transferase, pi 1
  • Synonyms
    Gst p-1, GstpiB
  • Feature Type
    protein coding gene
  • IDs
    MGI:95865
    NCBI Gene: 14870
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:4085411-4087912 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 3.75 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    55 from dbSNP Build 142
  • Strain Annotations
    12
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95865
 protein coding gene Chr19:4085407-4087985 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024641
 protein coding gene Chr19:860960-865355 (-)
A/J no annotation
AKR/J MGP_AKRJ_G0024581
 protein coding gene Chr19:850632-852588 (-)
BALB/cJ MGP_BALBcJ_G0024607
 protein coding gene Chr19:825013-827364 (-)
C3H/HeJ MGP_C3HHeJ_G0024375
 protein coding gene Chr19:847640-850278 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025055
 protein coding gene Chr19:879768-891945 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022485
 protein coding gene Chr19:780425-786269 (-)
CAST/EiJ MGP_CASTEiJ_G0023848
 protein coding gene Chr19:868492-871914 (-)
CBA/J MGP_CBAJ_G0024347
 protein coding gene Chr19:953722-956236 (-)
DBA/2J MGP_DBA2J_G0024475
 protein coding gene Chr19:792629-795362 (-)
FVB/NJ MGP_FVBNJ_G0024442
 protein coding gene Chr19:806429-810316 (-)
LP/J no annotation
NOD/ShiLtJ no annotation
NZO/HlLtJ MGP_NZOHlLtJ_G0025103
 protein coding gene Chr19:857416-859660 (-)
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    GSTP1, glutathione S-transferase pi 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GSTP1, glutathione S-transferase pi 1
  • Synonyms
    DFN7, FAEES3, GST3, GSTP, HEL-S-22, PI
  • Links
    NCBI Gene ID: 2950
    neXtProt AC: NX_P09211
    UniProt: P09211

  • Chr Location
    11q13.2; chr11:67583742-67586656 (+)  GRCh38
Human Diseases
more
  • Diseases
    54 with human GSTP1 associations

Human Disease Mouse Models
      
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Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    31 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mutant mice with null mutations in both Gstp1 and Gstp2 exhibit an increased susceptibility to DMBA and TPA induced skin papillomas. Male mutant mice exhibit an increased body weight with age.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    73
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    834
  • Tissues
    126
  • cDNA Data
    414
  • Literature Summary
    20
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14870 NCBI Gene Model | MGI Sequence Detail 2502 C57BL/6J ±  kb
    transcript NM_013541 RefSeq | MGI Sequence Detail 744 ZRU/MplStud  
    polypeptide P19157 UniProt | EBI | MGI Sequence Detail 210 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 420
      Genomic 4
      cDNA 416

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-10324
    References
    more
    • Summaries
      All 90
      Developmental Gene Expression 20
      Gene Ontology 13
      Phenotypes 31
    • Earliest
      J:48429 Hatayama I, et al., A cDNA sequence coding a class pi glutathione S-transferase of mouse. Nucleic Acids Res. 1990 Aug 11;18(15):4606
    • Latest
      J:351144 Wei C, et al., SIRT5-related lysine demalonylation of GSTP1 contributes to cardiomyocyte pyroptosis suppression in diabetic cardiomyopathy. Int J Biol Sci. 2024;20(2):585-605
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory