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H2-Eb2 Gene Detail
Summary
  • Symbol
    H2-Eb2
  • Name
    histocompatibility 2, class II antigen E beta2
  • Synonyms
    A130038H09Rik, H-2Eb2, Ia-5, Ia5
  • Feature Type
    protein coding gene
  • IDs
    MGI:95902
    NCBI Gene: 381091
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:34544639-34560386 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 17.98 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    4 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    8
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95902
 protein coding gene Chr17:34544477-34560386 (+)
129S1/SvImJ MGP_129S1SvImJ_G0023570
 protein coding gene Chr17:34334852-34349993 (+)
A/J MGP_AJ_G0023532
 protein coding gene Chr17:33166962-33182025 (+)
AKR/J MGP_AKRJ_G0023497
 protein coding gene Chr17:33556511-33572874 (+)
BALB/cJ MGP_BALBcJ_G0023536
 protein coding gene Chr17:33327607-33342335 (+)
C3H/HeJ MGP_C3HHeJ_G0023296
 protein coding gene Chr17:33914116-33929246 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023976
 protein coding gene Chr17:35619970-35634307 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021455
 protein coding gene Chr17:31134119-31150812 (+)
CAST/EiJ MGP_CASTEiJ_G0022796
 protein coding gene Chr17:34000996-34015378 (+)
CBA/J MGP_CBAJ_G0023274
 protein coding gene Chr17:37087133-37103543 (+)
DBA/2J MGP_DBA2J_G0023403
 protein coding gene Chr17:32512428-32526758 (+)
FVB/NJ MGP_FVBNJ_G0023369
 protein coding gene Chr17:32369391-32384276 (+)
LP/J MGP_LPJ_G0023480
 protein coding gene Chr17:34593757-34609197 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023392
 protein coding gene Chr17:36057481-36073404 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024019
 protein coding gene Chr17:33887968-33902340 (+)
PWK/PhJ MGP_PWKPhJ_G0022546
 protein coding gene Chr17:31450336-31465511 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022361
 protein coding gene Chr17:31850383-31864629 (+)
WSB/EiJ MGP_WSBEiJ_G0022857
 protein coding gene Chr17:33927246-33943920 (+)



Homology
more
  • Human Ortholog
    HLA-DRB1, major histocompatibility complex, class II, DR beta 1
  • Vertebrate Orthologs
    12
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HLA-DRB1, major histocompatibility complex, class II, DR beta 1
  • Synonyms
    DRB1, HLA-DR1B, HLA-DRB, SS1
  • Links
    NCBI Gene ID: 3123
    neXtProt AC: NX_P01911
    UniProt: P01911

  • Chr Location
    6p21.32; chr6:32577902-32589848 (-)  GRCh38
  • Human Ortholog
    HLA-DRB3, major histocompatibility complex, class II, DR beta 3
  • Synonyms
    DRB3, HLA-DPB1, HLA-DR1B, HLA-DR3B, HLA-DRB3*
  • Links
    NCBI Gene ID: 3125
    neXtProt AC: NX_P79483
    UniProt: P79483

  • Chr Location
    6p21.3
  • Human Ortholog
    HLA-DRB4, major histocompatibility complex, class II, DR beta 4
  • Synonyms
    DR4, DRB4, HLA-DR4B, HLA-DRB, HLA-DRB4*
  • Links
    NCBI Gene ID: 3126
    neXtProt AC: NX_P13762
    UniProt: P13762

  • Chr Location
    6p21.3
  • Human Ortholog
    HLA-DRB5, major histocompatibility complex, class II, DR beta 5
  • Synonyms
    DRB5, HLA-DRB5*
  • Links
    NCBI Gene ID: 3127
    neXtProt AC: NX_Q30154
    UniProt: Q30154

  • Chr Location
    6p21.32; chr6:32517353-32530287 (-)  GRCh38
Human Diseases
more
  • Diseases
    93 with human HLA-DRB1,HLA-DRB3,HLA-DRB4,HLA-DRB5 associations

Human Disease Mouse Models
      
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Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    230 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    28
  • GO References
    2
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    3
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000067341 Ensembl Gene Model | MGI Sequence Detail 15748 C57BL/6J ±  kb
transcript ENSMUST00000050325 Ensembl | MGI Sequence Detail 3392 Not Applicable  
polypeptide ENSMUSP00000056814 Ensembl | MGI Sequence Detail 287 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    4 Sequences
  • InterPro Domains
    IPR003597 Immunoglobulin C1-set
    IPR007110 Immunoglobulin-like domain
    IPR036179 Immunoglobulin-like domain superfamily
    IPR013783 Immunoglobulin-like fold
    IPR003006 Immunoglobulin/major histocompatibility complex, conserved site
    IPR050160 Major Histocompatibility Complex/Immunoglobulin
    IPR011162 MHC classes I/II-like antigen recognition protein
    IPR014745 MHC class II, alpha/beta chain, N-terminal
    IPR000353 MHC class II, beta chain, N-terminal
Molecular
Reagents
less
  • All nucleic 37
    Genomic 27
    cDNA 6
    Primer pair 1
    Other 3

    Microarray probesets 2
Other
Accession IDs
less
MGD-MRK-10385, MGD-MRK-10498, MGD-MRK-11048, MGD-MRK-11053, MGI:3588187
References
more
  • Summaries
    All 268
    Diseases 1
    Gene Ontology 2
    Phenotypes 230
  • Earliest
    J:5895 Delovitch TL, et al., Immunochemical evidence for three Ia loci in the I-region of the H-2 complex. J Exp Med. 1977 Dec 1;146(6):1549-60
  • Latest
    J:350703 Sharma P, et al., The lipid globotriaosylceramide promotes germinal center B cell responses and antiviral immunity. Science. 2024 Feb 16;383(6684):eadg0564
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory